Peculiarities of the Sorption of Amino Acids and Their Metabolites by Medicinal Carbon Sorbents

Isaieva, Y. V.; Farbun, I. A.; Trykhlib, V.A.

doi:10.1007/s11237-019-09589-3

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…This allows the removal of various toxins (low-and medium molecular weight substances, protein compounds). Therefore, in Institute for Sorption and Problems of Endoecology, National Academy of Sciences of Ukraine synthesized activated carbon KARBON™, which is based on coconut shell [7], is used as a hemosorbent for purification of blood outside the human body [8] due to its high structural and adsorption-kinetic properties [9]. Taking into account the special biochemical and toxicological effects of tryptophan and phenylalanine metabolites on the human body, it was proposed to use KARBON TM as an enterosorbent to remove excess aromatic and heterocyclic amino acids [10].…”

Section: Introductionmentioning

confidence: 99%

Porous Structure Influence of Coconut Carbon Sorbents and Acidity on the Sorption of Some Biologically Active Organic Compounds

Farbun¹,

Trykhlib²

2020

Phys. Chem. Solid St.

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The paper investigates the regulation of the hydrophobicity of KARBON™ carbon adsorbents by restoring its surface during heat treatment in argon and hydrogen, as well as oxidizing it with nitric acid. The sorption capacity of KARBON™ with respect to the tryptophan, arginine, indole, creatinine and vitamin B12 as biologically active organic compounds of different molecular weight was studied. It was determined that the adsorption capacity of KARBON™ samples with respect to all the studied substances changes as follows: Ind>Cr>Trp>Arg>B12. It has been shown that the sorption capacity of argon-treated KARBON™ adsorbent at pH=7.5 is 2.6; 2.7 and 0.09 mmol/g in relation to tryptophan, creatinine and vitamin B12, respectively. The adsorption capacity of these compounds is almost unchanged when the acidity changes from 7.5 to 2.0. The results obtained allows the use of KARBON™ adsorbent as a therapeutic and/or prophylactic agent for oral administration in chronic kidney and liver diseases, as well as a hemosorbent for the purification of blood outside the human body.

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Section: Introductionmentioning

confidence: 99%

Porous Structure Influence of Coconut Carbon Sorbents and Acidity on the Sorption of Some Biologically Active Organic Compounds

Farbun¹,

Trykhlib²

2020

Phys. Chem. Solid St.

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Selectivity of Tryptophan and Phenylalanine Adsorption by Activated Coconut Carbon of Medical Assignment

Farbun¹,

Trykhlib²

2023

Theor Exp Chem

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Characteristics of the sorption of aromatic and heterocyclic amino acids by activated coconut carbons with different bulk density

2020

VKhKhT

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Peculiarities of the Sorption of Amino Acids and Their Metabolites by Medicinal Carbon Sorbents

Cited by 3 publications

References 8 publications

Porous Structure Influence of Coconut Carbon Sorbents and Acidity on the Sorption of Some Biologically Active Organic Compounds

Porous Structure Influence of Coconut Carbon Sorbents and Acidity on the Sorption of Some Biologically Active Organic Compounds

Selectivity of Tryptophan and Phenylalanine Adsorption by Activated Coconut Carbon of Medical Assignment

Characteristics of the sorption of aromatic and heterocyclic amino acids by activated coconut carbons with different bulk density

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