Pediatric epilepsy: The Indian experience

Gadgil, Pradnya; Udani, Vrajesh

doi:10.4103/1817-1745.85732

Cited by 20 publications

(9 citation statements)

References 16 publications

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“…9 NCC is responsible for 0.4% of neurological complaints in children. In present study, it was found that inflammatory granulomata were the most common abnormality.…”

Section: Discussionmentioning

confidence: 99%

Neuroimaging in pediatric seizures

2016

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Background: Accurate etiological diagnosis of seizures in children is important to begin an effective treatment. MRI is an excellent neuroimaging tool that is highly accurate. It helps in diagnosis, determining the treatment protocol and predicting the outcome. Dedicated studies in paediatric population using MRI brain have been even fewer till date in India. Current study aims to find the common etiology of pediatric seizures on MRI in a developing country like India.Methods: Hospital based retrospective study. 105 cases in age group between 0 months to 12 years. Seen between 2014 till date included in the study. All cases underwent MRI.Results: Most common imaging findings were inflammatory granuloma in 10 (9.5%). Other findings were- Hypoxic ischemic encephalopathy (HIE) in 5 (4.7%), cerebral atrophy in 2 (1.9%), focal dysmyelination in 3 (2.8%), calcifying granuloma in 3 (2.8%) and periventricular leucomalacia in 2 (1.9%). Uncommon findings were that of lissencephaly, dysgenesis of corpus callosum, mesial temporal sclerosis, AV malformation, periventricular hemorrhage, schizencephaly, abscess and infarction in one child each (0.9% each). 69 children had no abnormal findings in brain.Conclusions: The commonest etiology of seizures is inflammatory granuloma. Early recognition of potentially treatable diseases helps in timely treatment and arrest of progression of disease. It is highly recommended to use MRI as primary investigation for seizures. Every effort should be made to provide facility of MRI for management of seizures in all parts of India.

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“…9 NCC is responsible for 0.4% of neurological complaints in children. In present study, it was found that inflammatory granulomata were the most common abnormality.…”

Section: Discussionmentioning

confidence: 99%

Neuroimaging in pediatric seizures

2016

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“…Precise etiological determination of epilepsy is challenging due to the poor accessibility and affordability of neuroimaging studies and other investigations (such as genetic studies) in India. Febrile seizures, head injury, positive family history of epilepsy, and developmental delay have been found to be the risk factors for epilepsy in Indian studies (1).…”

Section: Introductionmentioning

confidence: 99%

“…It is a great public health care concern in developing countries as it accounts for sizeable morbidity and economic loss. Limited epidemiological data in India show that the incidence and prevalence rates are surprisingly similar to those in the developed world (1). An Indian study reported the annual total expense per epilepsy patient to be 344 dollars (estimated as 5 million cases), equivalent to 0.5% of gross national product (2).…”

Section: Introductionmentioning

confidence: 99%

Predictors of health related quality of life in childhood epilepsy and comparison with healthy children: findings from an Indian study

et al. 2017

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Background/aim: Children with epilepsy have reduced health-related quality of life (HRQOL) due to disease and medications. We aimed to assess child-reported HRQOL in Indian children with epilepsy and compare it with that in healthy children. Materials and methods:A cross-sectional study of 256 children with epilepsy aged between 5 and 18 years on antiepileptic drug (AED) treatment for at least 3 months was performed and 125 age and sex matched healthy children were included. A generic version of the Pediatric Quality of Life (PedsQL version 4) scale was used to assess HRQOL.Results: Children with epilepsy had diminished scores in total score and all subdomains of PedsQL as compared to healthy children. Children with epilepsy on polytherapy had diminished HRQOL compared with those on monotherapy. Children with generalized seizures or with symptomatic epilepsy had diminished HRQOL. Significant predictors of poor HRQOL were adverse drug reactions (ADRs) to AED, polytherapy, longer duration of epilepsy, shorter seizure-free interval, and seizure frequency. Conclusions:Children with epilepsy have diminished HRQOL than healthy children in all subdomains of PedsQL. Significant predictors are ADRs to AED, polytherapy, longer duration of epilepsy, shorter seizure-free interval, and seizure frequency. Comprehensive management of children with epilepsy must go beyond seizure control.

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“…A pediatric epilepsy study carried out in Mumbai found that 55.3% children had partial seizures while 27% had generalized seizures 1. In a study on 123 children with refractory epilepsy, it was found that children whose onset was below the age of two years were mostly males with co-morbid neurological or psychiatric conditions with a certain seizure type acting as a risk factor for refractoriness 2. Children with epilepsy have other co-existing health conditions that significantly affect their health and intensifies their parents’ worries and anxiety as they require continued surveillance and are often in a state of uncertainty and apprehension.…”

Section: Introductionmentioning

confidence: 99%

Parental Knoweldge, Attitude, and Perception about Epilepsy and Sociocultural Barriers to Treatment

Rani¹,

Thomas²

2019

J Epilepsy Res

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The present study focused on assessing parental knowledge, attitudes, and perceptions about epilepsy as well as addressing the socio-cultural barriers to its treatment. Methods: Data were collected from outpatient consultations in the neurology department of a tertiary referral center in South India. Parents of sixty children suffering from epilepsy in the age-group of 4-15 years were interviewed to explore their knowledge, attitudes, and perceptions about epilepsy. They were recruited in 2015 over a consecutive period of six months. The tools administered were: socio-demographic schedule; clinical profile; a knowledge, attitude, and perception questionnaire prepared by the researcher; and a few case studies with psychosocial interventions. Results: The mean age of the parents who brought their children to the hospital was 37.2 years, with 71.7% being male, of which, 36% were educated up to secondary/intermediate level and were of lower socioeconomic status. The mean age of the children with epilepsy was 8.4 years with 66.7% of them being male. Among them, 50% had the most commonly occurring generalized seizures and 26.7% had the co-morbid condition of cerebral palsy. Around 37.7% parents attributed the seizures to evil spirits or supernatural powers, 52.5% to mental illness, and 72.1% were influenced by their families to initially seek religio-spiritual or traditional treatment in desperation for a cure of the illness. In total, 91.8% of the parents visited holy places, made "mannats", or prayed in worship for hours for their child's recovery.

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Pediatric epilepsy: The Indian experience

Cited by 20 publications

References 16 publications

Neuroimaging in pediatric seizures

Neuroimaging in pediatric seizures

Predictors of health related quality of life in childhood epilepsy and comparison with healthy children: findings from an Indian study

Parental Knoweldge, Attitude, and Perception about Epilepsy and Sociocultural Barriers to Treatment

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