Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2

Selladurai, Elilarasi; Varadarajan, Poovazhagi; G, Kumaravel; Srividya, V Gomathy; Solomon, Joshua

doi:10.1007/s12098-021-03954-8

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…For our thinking, it is possible that cardiac involvement reflects the endothelial damage produced by this condition ( 22 ) but also reflects the inexperience of healthcare system response to a new disease, as well as the delays that could exist in healthcare consultation. We also think that this high proportion of coronary compromise and cardiac involvement could be related to the severity of the diseases because all patients required PICU admission; however, Elilarasi et al ( 23 ) reported 68% of coronary compromise, but only 50% of their patients required PICU; this supports the fact that ethnicity could be involved in this outcome.…”

Section: Discussionmentioning

confidence: 80%

Multisystemic Inflammatory Syndrome in Children From the South of Colombia: One Year of Experience

et al. 2022

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BackgroundMultisystemic inflammatory syndrome in children (MIS-C) is one of the most severe presentations of COVID-19 infection in pediatrics. Currently, we have few studies that describe the characteristics of this condition in Colombian children.ObjectiveTo describe the clinical and epidemiological characteristics of children hospitalized with MIS-C in Neiva, Colombia.MethodsObservational follow-up study of a cohort of children with MIS-C for 12 months (May 15, 2020, to May 30, 2021) in two hospitals in the city of Neiva. Epidemiological data, clinical characteristics, laboratory characteristics, cardiological evaluation, treatment, and clinical outcomes were analyzed.ResultsWe included 34 patients who met the diagnosis of MIS-C. The median age was 68 months. Some type of nutritional issue was observed by 43.75% of those under 5 years of age and by 27.78% of those over 5 years of age. Gastrointestinal symptoms were the most frequent, with vomiting, diarrhea, and abdominal pain being the most frequent by 79, 70, and 67%, respectively. By 77% of the patients, a history of SARS-COV-2 infection was documented through IgG. In the echocardiogram, 35.4% of the patients had systolic dysfunction, followed by coronary involvement by 35%.ConclusionThis study describes a series of cases of children with MIS-C in Colombia. Gastrointestinal manifestations were predominant. Mortality was high in comparison to other countries but similar to that reported in Colombia. This fact was associated with relevant pathological background. More training is required for physicians in order to have a better understanding of the disease so as to have an early diagnosis and timely treatment.

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Section: Discussionmentioning

confidence: 80%

Multisystemic Inflammatory Syndrome in Children From the South of Colombia: One Year of Experience

et al. 2022

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“…In this issue of Indian Journal of Pediatrics, Elilarasi et al have published a series of 65 children with PMIS-TS from southern India [4]. This study elucidates the clinical spectrum of PMIS-TS.…”

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confidence: 80%

“…In our experience most of these resolved at 6-wk followup [5]; however, the outcome of coronary abnormalities has not been reported in the present study. In the Elilarasi et al study, 75% (3/4) of children presenting with acute abdomen were operated [4]; this is an alarming observation and reemphasizes the fact that PMIS-TS can present with various gastrointestinal manifestations including acute abdomen; and a high index of suspicion can avoid unwarranted surgical interventions. Another intriguing observation in this series is the presence hypertension observed in one child, although the authors have not discussed the possible reasons for same, it might not be related to PMIS-TS, which typically presents with hypotension.…”

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confidence: 99%

The Enigma of Pediatric Multisystem Inflammatory Syndrome Temporally Associated with SARS-CoV-2 (PMIS-TS)

Bagri

2022

Indian J Pediatr

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The study team has made all possible attempts to rule out coinfections such as dengue, scrub typhus, etc., which is very crucial in settings like India, as there would be many infectious febrile conditions, which may have clinical features overlapping with PMIS-TS. With increasing seroprevalence for COVID antibodies, many febrile illnesses shall meet the definition of PMIS-TS. If overlooked, these children with underlying alternative diagnosis may erroneously receive immunosuppressive agents, particularly steroids, which may flare up the underlying infection.Thus, till a reliable diagnostic biomarker of PMIS-TS is available or the existing definitions are revised, the onus lies on us clinicians to exclude all possible causes of fever before committing the diagnosis of PMIS-TS. On the other hand, timely diagnosis of PMIS-TS is also equally important to curtail the morbidity and mortality associated with PMIS-TS. The reported mortality in Indian series including the present study is high (6%-27%) as compared to the western world (1%-2%) [5][6][7]; these observations highlight the need of opportune diagnosis and management of PMIS-TS.

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In-hospital unfavorable outcomes of MIS-C during 2020–2022: a systematic review

Alvarado-Gamarra,

Alcalá-Marcos,

Balmaceda-Nieto

et al. 2024

Eur J Pediatr

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Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2

Cited by 5 publications

References 20 publications

Multisystemic Inflammatory Syndrome in Children From the South of Colombia: One Year of Experience

Multisystemic Inflammatory Syndrome in Children From the South of Colombia: One Year of Experience

The Enigma of Pediatric Multisystem Inflammatory Syndrome Temporally Associated with SARS-CoV-2 (PMIS-TS)

In-hospital unfavorable outcomes of MIS-C during 2020–2022: a systematic review

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