Pediatric Kikuchi-Fujimoto disease: A clinicopathologic study and the therapeutic effects of hydroxychloroquine

Lin, Yung-Chih; Huang, Hsiu-Hui; Nong, Bao-Ren; Liu, Po-Yen; Chen, Yingyao; Huang, Ya-Ling; Chiou, Yee-Hsuan; Lee, Herng‐Sheng

doi:10.1016/j.jmii.2017.08.023

Cited by 22 publications

(41 citation statements)

References 27 publications

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“…The male predominance in younger age groups as shown in present study group were similar to other studies on childhood Kikuchi disease. 6,7 Authors are reporting two cases that presented at very young age (1 year and 3 years of age), both of which are very rare age of presentation in pediatric Kikuchi disease. The first child had associated primary immunodeficiency (agammaglobulinemia) and the 2 nd child presented with HLH.…”

Section: Discussionmentioning

confidence: 99%

“…Generalized lymphadenopathy was observed in (26.9%) of cases, which was similar to the observation in other studies. 6,7 Majority of cases were firm (88%), tender (38.5 %), and matted (30.8 %). These features were also similar to other studies on pediatric Kikuchi disease.…”

Section: Discussionmentioning

confidence: 99%

“…5 Kikuchi-Fujimoto disease varies in its prevalence, clinical profile, severity, outcome among different age groups, ethnicity and gender. 6 Punnen A et al Int J Contemp Pediatr. 2019 Mar;6(2): [664][665][666][667][668][669] International Journal of Contemporary Pediatrics | March-April 2019 | Vol 6 | Issue 2 Page 665 KFD in the children has many difference compared to adult including its clinical presentation, manifestations and prognosis.…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathologic study of Kikuchi’s disease in children in a tertiary hospital in South India

Punnen

Kanagalakshmi

Manipadam

et al. 2019

Int J Contemp Pediatr

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Background: The aim of this study was to evaluate the clinical and laboratory characteristics, treatment modalities and outcome of children with Kikuchi’s disease.Methods: A retrospective cross-sectional study was conducted among all children, histopathologically diagnosed with KFD. Clinical, laboratory data and treatment outcomes were analysed.Results: During the study period, 53 children histopathologically confirmed as KFD were enrolled in the study. There were 36 males and 17 females. The lymph node involvements were mostly cervical with bilateral predisposition (63.5%), firm (88%), matted (30.8%) and tenderness (38.5%). Fever, headache, vomiting, chills, myalgia and rash were other common presentations other than cervical lymphadenopathy. The associated laboratory findings include anemia (71.2%), leukopenia especially lymphopenia (31.4%), monocytosis (21.6%), thrombocytopenia (16.3%), elevated CRP (53.1%), ESR (83.7%), LDH (100%) and elevated liver enzymes. Most of the children were managed conservatively (49.1%). Corticosteroids were administered for (22.6 %) of patients. Recurrence occurred in 4 children (7.5 %) and 13 children (24.5%) had other associated diseases.Conclusions: KFD should be suspected in well children with febrile cervical lymphadenopathy, especially with leukopenia, monocytosis, and elevated CRP, ESR, LDH, Liver enzymes. KFD in children can have rarely atypical presentations and coexist with other diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinicopathologic study of Kikuchi’s disease in children in a tertiary hospital in South India

Punnen

Kanagalakshmi

Manipadam

et al. 2019

Int J Contemp Pediatr

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“…KD is mostly self-limiting, but some studies have reported that steroids or hydroxychloroquine may be helpful in shortening the clinical course or reducing the severity of disease, especially in recurrent or severe cases. [23][24][25][26] Since these studies were mostly case reports, further prospective research is needed to define the role of steroids or hydroxychloroquine in the treatment of KD.…”

Section: Figurementioning

confidence: 99%

<p>Risk Assessment of Recurrence and Autoimmune Disorders in Kikuchi Disease</p>

Jung¹,

Lee²,

Sh³

2020

RMHP

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Purpose: Kikuchi disease (KD) is typically a benign disease. Recent studies reporting recurrence or serious cases suggest a possible association of KD with systemic autoimmune disorders. We performed a long-term analysis of the characteristics of KD in patients of all ages and assessed KD recurrence or progress to systemic autoimmune disorders. Patients and Methods: Electronic medical records of patients diagnosed with KD between April 1995 and May 2017 were reviewed for clinical and laboratory manifestations. Results: In total, 480 patients were confirmed to have KD based on histopathology findings. The mean age at KD diagnosis was 24.4 years. Recurrence occurred in 11.3% of patients; 2.7% developed autoimmune diseases after KD diagnosis. Patients who experienced recurrence had more extranodal symptoms, lymphopenia, and a longer lymphopenia-recovery duration. Patients who developed autoimmune diseases after KD were more likely to have extranodal symptoms, KD recurrence, and anti-nuclear antibody positivity. Conclusion: KD patients with risk factors need to be followed-up for KD recurrence and the development of systemic autoimmune diseases.

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“…The medical charts of patients who were below 16 years of age and admitted between 2007 Lin et al 10 Kang et al and 2016 with a suspected diagnosis of KFD were included. All the clinical manifestations, laboratory results and the histopathology of the excised LNs were reviewed.…”

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confidence: 99%

Kikuchi-Fujimoto Disease: Eleven Pediatric Cases and Literature Review

et al. 2020

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Kikuchi-Fujimoto disease (KFD) is a rare lymphohistiocytic disorder of unknown etiology. KFD was first described in 1972 as a case series in form of benign necrotizing lymphadenitis with distinctive histologic findings. 1 The most common clinical features in KFD is prolonged fever and cervical lymphadenopathy which is in most cases unilateral and painful. 2-4 Kikuchi-Fujimoto disease has a worldwide distribution with a higher prevalence among Asian people. 5,6 The first pediatric case of KFD was reported in 1990, which was followed by many studies reporting considerable number of children with KFD. 3,7 Diagnosis of KFD depends upon presence of appropriate histopathology of the lymph

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Pediatric Kikuchi-Fujimoto disease: A clinicopathologic study and the therapeutic effects of hydroxychloroquine

Cited by 22 publications

References 27 publications

Clinicopathologic study of Kikuchi’s disease in children in a tertiary hospital in South India

Clinicopathologic study of Kikuchi’s disease in children in a tertiary hospital in South India

<p>Risk Assessment of Recurrence and Autoimmune Disorders in Kikuchi Disease</p>

Kikuchi-Fujimoto Disease: Eleven Pediatric Cases and Literature Review

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