Pediatric males receiving hematopoietic stem cell transplant lose their male disadvantage in disease risk after the procedure: A retrospective observational study

Nardi, Laura De; Simeone, Roberto; Torelli, Lucio; Maestro, Alessandra; Zanon, Davide; Barbi, Egidio; Maximova, Natalia

doi:10.1002/ijc.33978

Cited by 4 publications

(3 citation statements)

References 40 publications

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“…A further potential explanation for the disappearance of the sex difference in the HSCT group could be found in the theory that the HSCT and its previous conditioning regimen could flatten the hormonal differences between males and females for a certain period, reducing the influence of sex on transplant-related outcomes, as some studies suggest [57]. According to this thesis, it would be possible to witness an equalization in the incidence of clinical situations that would otherwise be influenced by sex.…”

Section: Discussionmentioning

confidence: 97%

Parenteral Nutrition in the Pediatric Oncologic Population: Are There Any Sex Differences?

De Nardi,

Sala,

Turoldo

et al. 2023

Nutrients

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Gender-based medicine is attracting increasing interest every day, but studies on pediatric populations are still limited. In this setting, sex differences among patients undergoing total parenteral nutrition (TPN) have not been previously reported. This study investigated the presence of sex differences in parenteral nutrition composition and outcomes among a cohort of pediatric patients admitted at the Oncohematology and Bone Marrow Transplant Unit of the Institute for Maternal and Child Health “Burlo Garofolo” of Trieste, Italy. For all 145 recruited patients (87 males, 58 females), the following data were collected: age, sex, volume and duration of TPN, macro- and micronutrient composition of TPN bags, electrolytic or blood gases imbalance, glycolipid alterations, liver damage during TPN, and the incidence of sepsis and thrombosis. The analysis showed that females required higher daily phosphate intake (p = 0.054) and essential amino acid supplementation (p = 0.07), while males had a higher incidence of hypertriglyceridemia (p < 0.05) and cholestasis. A higher incidence of sepsis was found in the non-transplanted male population (p < 0.05). No significant differences were appreciable in other analyzed variables. This study aims to create a basis for future gender-based nutritional recommendations in the pediatric field.

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Section: Discussionmentioning

confidence: 97%

Parenteral Nutrition in the Pediatric Oncologic Population: Are There Any Sex Differences?

De Nardi,

Sala,

Turoldo

et al. 2023

Nutrients

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“…Most studies exploring the risk factors for HCC development are based on observational studies and clinical experience. However, the major disadvantage of an observational study is that its validity is threatened by confounding by indication ( De Nardi et al, 2022 ). Furthermore, studies have shown that genetic factors may also independently modulate HCC risk ( Shimokawa et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Liver function indicators and risk of hepatocellular carcinoma: a bidirectional mendelian randomization study

Qin,

Wang,

Yuan

et al. 2024

Front. Genet.

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Observational studies have shown an association between liver dysfunction and hepatocellular carcinoma (HCC), but the causality relationship between them is unclear. We aimed to determine whether there is a bidirectional causal relationship between liver function indicators (alanine aminotransferase, ALT; aspartate aminotransferase, AST; alkaline phosphatase, ALP; γ-glutamyltransferase, GGT) and HCC. Our two-sample Mendelian randomization (MR) study acquired single nucleotide polymorphisms (SNPs) associated with liver function indicators (ALT, n = 134,182; AST, n = 134,154; GGT, n = 118,309; ALP, n = 105,030) and with HCC (n = 197,611) from publicly available genome-wide association studies (GWAS) of East Asian ancestry in Japan (BioBank Japan, BBJ). Univariable MR analyses were performed to identify whether the genetic evidence of exposure was significantly associated with outcome. Multivariable MR analysis was conducted to estimate the independent effects of exposures on outcome. Univariable MR analysis indicated that the level of ALT, AST, and GGT was the risk factor for HCC incidence. Meanwhile, multivariable MR analysis revealed that AST was an independent risk factor for HCC. The hazard ratio (HR) of the probability of HCC was 3.045 [95% confidence interval (95%CI), 1.697–5.463, p = 0.003] for AST. The results of reverse MR analyses showed that gene-predictive HCC incidence could increase the levels of AST (HR = 1.031, 95%CI: 1.009–1.054, p = 2.52 × 10−4) and ALT (HR = 1.040, 95%CI: 1.019–1.063, p = 0.005). Meanwhile, HCC may be negatively correlated with ALP levels (HR = 0.971, 95%CI: 0.947–0.995, p = 0.018). This study provides evidence to support that genetically predicted higher levels of AST are related to increased risk of HCC, with no strong evidence of a causal effect of genetically predicted ALP, ALP, and GGT on HCC. In addition, genetic predisposition to HCC could influence blood concentration of ALT, AST, and ALP. Thus, this may create a vicious cycle.

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“…Reasons for higher cancer risk in men are not fully perceptible but probably react more exposure to cancer-causing environmental, occupational and biological risk factors. Sex differences in endogenous hormones and immune function may also play a significant role in different cancers ( De Nardi et al, 2022 ). In the current cancer treatment, chemotherapy is still the dominant treatment strategy ( Network, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, docking studies, biological activity of carbon monoxide release molecules based on coumarin derivatives

Liu¹,

Chen

Cui³

et al. 2022

Front. Chem.

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In the present work, we synthesized seven complexes. All complexes were identified by ESI-HRMS, 1H-NMR, 19F-NMR and 13C-NMR spectroscopies. The synthesized complexes were tested for their anticancer activities in vitro against three different human cell lines, including breast MDAMB231, cervical Hela, liver HepG2. IC50 values of complexes 1-7 were 34.98–667.35 µM. Complex 5 revealed higher sensitivity towards MDAMB231 cells with IC50 values 34.98 μM in comparison to 5-FU as positive control. Moreover, complex 5 caused a decrease of mitochondrial membrane potential and effectively induced ROS production against MDAMB231 cells. Western blot analysis showed that complex 5 could up-regulate the expression of Bax protein and down-regulate the expression of Bcl-2, activate Caspase-3, slightly down-regulate the expression of HO-1. The docking studies showed that complex 5 could be interacted with Bcl-2 protein through hydrophobic interactions, hydrogen bonds and salt bridges to enhance the binding affinity. All the analyzed coumarins obeyed the Lipinski’s rule of five for orally administered drugs. Based on the aforementioned results, it suggests that the complex induced apoptosis cell via mitochondria pathways. Collectively, complex 5 could be considered as a promising hit for new anti-breast cancer agents. Carbonyl cobalt CORMs, as potential anticancer therapeutic agents, provided a new idea for the development of metal anticancer drugs.

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Pediatric males receiving hematopoietic stem cell transplant lose their male disadvantage in disease risk after the procedure: A retrospective observational study

Cited by 4 publications

References 40 publications

Parenteral Nutrition in the Pediatric Oncologic Population: Are There Any Sex Differences?

Parenteral Nutrition in the Pediatric Oncologic Population: Are There Any Sex Differences?

Liver function indicators and risk of hepatocellular carcinoma: a bidirectional mendelian randomization study

Synthesis, docking studies, biological activity of carbon monoxide release molecules based on coumarin derivatives

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