Pediatric Mastocytosis: A Review of the Literature

Frieri, Marianne; Quershi, Mahvish

doi:10.1089/ped.2013.0275

Cited by 55 publications

(60 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The same histopathologic features are seen in diseases such as necrotizing vasculitis, 1 sarcoidosis, 2 Langerhans cell histiocytosis, Churg-Strauss syndrome, 3 Kimura's disease, 4 rheumatoid fever, 5 hypereosinophilic syndrome, 6 and allergic reactions to norfloxacin, 7 glyburide, 8 and parasites (fascioliasis, ascariasis, clonorchiasis, schistosomiasis, and anisakiasis). [9][10][11][12][13][14][15][16][17][18] Because eosinophilic granuloma appears to represent a kind of type I allergic reaction, eosinophilic granuloma concurrently occurs systemically or in organs where type I allergic reactions arise.…”

Section: Discussionmentioning

confidence: 78%

“…25 Obstruction of Glisson's sheath would induce peripheral parenchymal necrosis of the liver, and parasite ova or the parasites themselves would induce type I allergic inflammation. Presinusoidal necrosis and granulation can also be caused by copper, 27,28 arsenic, 29 vinyl chloride, 27 systemic mastocytosis, 6 some cytotoxic drugs, 30,31 and pathogenic bacteria 32 such as Coxiella burnetii, 33 although inflammatory granulation does not always represent a type I allergic reaction. Some allergens carried by the intestinal veins (or hepatic arteries) could cause EGL in the same manner as VLM.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Solitary Hepatic Eosinophilic Granuloma Accompanied by Eosinophilia Without Parasitosis: Report of a Case

Yamamoto¹,

Miyazaki²,

Kurashima³

et al. 2015

International Surgery

View full text Add to dashboard Cite

A 43-year-old Japanese woman visited for a hepatic tumor incidentally found. We suspected eosinophilic granuloma of the liver (EGL) due to visceral larva migrans (VLM). However, neither past history nor medical interview indicated a risk of parasitosis. Blood testing revealed eosinophilia, serum examination showed normal results for immunoglobulin E, and enzyme-linked immunosorbent assay yielded negative for Toxocara and Anisakis. Gastric and colonic endoscopy revealed normal features. Several imagings showed central necrosis of the tumor. After informed consent, laparoscopic resection was performed. Histopathological examination showed EGL without parasites. No recurrence had occurred postoperatively. Most reports documented that EGL are caused by VLM. However, parasites are not always demonstrable on serum, histopathological, or immunochemical examinations. When acting as allergens to induce type I responses, microscopic agents other than parasites in the intestinal tract could induce eosinophilic inflammation in the liver. Accumulation of more cases should help clarify other pathogeneses for EGL.

show abstract

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Solitary Hepatic Eosinophilic Granuloma Accompanied by Eosinophilia Without Parasitosis: Report of a Case

Yamamoto¹,

Miyazaki²,

Kurashima³

et al. 2015

International Surgery

View full text Add to dashboard Cite

show abstract

“…Patients with cutaneous mastocytosis do not fulfill the criteria for the diagnosis of systemic mastocytosis. The majority of children with cutaneous mastocytosis display spontaneous healing until early adulthood (2,14). Results from the National Institutes of Health (NIH) study revealed that 83% of children with mastocytosis present with pruritus, 65 % with flushing, 53% with vesicles, 41% with abdominal pain, 18 % with bone pain, and 12% with headache (15).…”

Section: Discussionmentioning

confidence: 99%

An Unusual Trigger for Cutaneous Mastocytosis: The Insulin Pump

Akelma¹,

Buluş²,

Koçak³

et al. 2017

Asthma Allergy Immunol

View full text Add to dashboard Cite

ÖZMastositoz cilt başta olmak üzere kemik iliği, karaciğer, dalak, lenf nodları ve gastrointestinal sistemde mast hücrelerinin klonal artışı karakterize nadir görülen bir hastalıktır. Bazı faktörlerin mastositozlu hastaların semptomlarını tetiklediği bilinmektedir. Bu yazıda, Tip 1 diabetes mellitus (DM) olan hastada, insülin pompa tedavisine bağlı semptomları tetiklenen kutanöz mastositoz olgusu sunulmuştur. Kutanöz mastositoz ve Tip 1 DM tanısı konulan 13 yaşındaki erkek çocukta, insülin pompa ile verilen insülin lispro tedavisinden 2-3 gün sonra meydana gelen çok sayıda kaşıntılı papüler lezyonlar görüldü. Mastositoz olarak değerlendirilen lezyonlardan alınan punch biyopside papiller dermiste yaygın mast hücre infiltrasyonu görüldü. Mevcut bulgulardan yola çıkarak, insülin pompa kateterinin lokal mikro travma ile fiziksel uyaran oluşturduğu ve mastositoz lezyonlarının buna bağlı meydana geldiği düşünüldü. Pompa insülin tedavisi kesilip kateter uygulamasından vazgeçildi. İzleminde yeni lezyon çıkmadığı ve gluteal ve periumblikal bölgedeki lezyonların da hiperpigmentasyon ile düzeldiği görüldü. Doğrulama için yeniden insülin pompa kateteri takılan yerlerde 3 gün sonra aynı lezyonlar tekrarladı. Bu olgu nedeniyle, en az 48 saatlik süre boyunca cilt altında kalan kateterin, mastositozda lezyonları tetikleyebileceğini literatürde ilk defa ortaya koyduk. ABSTRACTMastocytosis is a relatively infrequent disorder characterized by mast cell proliferation within primarily the skin, but also various organs such as the bone marrow, liver, spleen, lymph nodes and the gastrointestinal system. Several factors are known to induce symptoms in patients with mastocytosis. A 13-year-old boy with cutaneous mastocytosis and type 1 diabetes mellitus developed multiple itchy papules 2 to 3 days after he started receiving insulin (lispro) pump therapy. Punch biopsy revealed widespread mast cell infiltration on the papillary dermis. We hypothesized that the insulin pump catheter caused a physical stimulus due to local microtrauma and resulted in the formation of the lesions. We, therefore, discontinued insulin pump treatment and switched to SC insulin therapy. While previous lesions healed successfully, no new lesions occurred. To confirm our hypothesis, we repeated the procedure and observed the occurrence of similar lesions around the insulin pump catheter. Herein, we present for the first time, a patient with type 1 diabetes mellitus and cutaneous mastocytosis who developed exacerbation of lesions during insulin pump therapy.Anahtar kelimeler: Mastositoz, kateter, tetikleyici

show abstract

“…Szacuje się, że 30-50% dorosłych chorych doświadcza reakcji anafilaktycznych [10,12,14], natomiast u dzieci chorujących na mastocytozę częstość reakcji anafilaktycznych oceniana jest na 5,5-9% [3,5,10]. Objawy zależne od mediatorów oraz ciężkie reakcje anafilaktyczne u chorych na mastocytozę mogą być wyzwalane przez różnorodne czynniki, takie jak: jady owadów błonkoskrzydłych, leki, pokarmy, alkohol, stres emocjonalny, wysiłek fizyczny, zabiegi inwazyjne, zakażenia, czynniki fizyczne oraz niezidentyfikowane czynniki [9][10][11][12][14][15][16][17][18][19][20][21][22][23][24][25]. Według danych z piśmiennictwa nie tylko częstość występo-wania, lecz także czynniki wyzwalające oraz indywidualne ryzyko wystąpienia objawów zależnych od mediatorów oraz reakcji anafilaktycznych różnią się u dzieci i u dorosłych chorujących na mastocytozę [5,10,12,16,17].…”

Section: Mediatory Uwalniane Przez Mastocyty I Ich Znaczenie Biologiczneunclassified

Drug hypersensitivity reactions and allergy in patients with mastocytosis

Czarny¹,

Lange²,

Niedoszytko³

et al. 2017

View full text Add to dashboard Cite

StreSzczenieMastocytoza jest rzadką chorobą szpiku charakteryzującą się nadmierną proliferacją i gromadzeniem się mastocytów w skórze i narządach wewnętrznych. U dzieci najczęstsza jest skórna postać tej choroby. Postać układowa pojawia się przede wszystkim u dorosłych. U chorych na mastocytozę, zarówno skórną, jak i układową, mogą występować objawy zależne od mediatorów uwalnianych przez mastocyty, takie jak: świąd skóry, flushing, hipotensja, bóle brzucha, biegunki, bóle głowy oraz reakcje anafilaktyczne. Szacuje się, że reakcje anafilaktyczne występują u około 50% dorosłych i u około 9% dzieci chorych na mastocytozę. Reakcje anafilaktyczne mogą być wywołane przez różne czynniki, m.in. jady owadów błonkoskrzydłych, leki, czynniki fizyczne, wysiłek, zakażenia, alkohol, niektóre pokarmy, alergeny. Do leków związanych z potencjalnym ryzykiem wystąpienia reakcji anafilaktycznych zalicza się: niesteroidowe leki przeciwzapalne, antybiotyki, opioidy, środki kontrastowe oraz leki anestezjologiczne. Odpowiednie przygotowanie do planowanego zabiegu inwazyjnego oraz długoterminowa profilaktyka pozwalają zmniejszyć ryzyko wystąpienia reakcji anafilaktycznej u chorych na mastocytozę. AbStrActMastocytosis is a rare myeloproliferative disease caused by excessive proliferation and accumulation of mast cells in the skin and internal organs. The most common variant of mastocytosis in children is cutaneous mastocytosis. Systemic mastocytosis dominates in adults. Both CM and SM patients suffer from mast cell mediator-related symptoms such as itching, flushing, hypotension, abdominal pain, diarrhea, headache and anaphylaxis. The prevalence of anaphylaxis in patients with mastocytosis has been estimated to be about 50% in adults and about 9% in children. Anaphylaxis may be caused by many triggers including hymenoptera sting, drugs, physical factors, exercise, infections, alcohol, some food types and allergens. Drugs which may provoke anaphylaxis include nonsteroidal anti-inflammatory drugs, antibiotics, opioids, contrast media and muscle relaxants. Appropriate preparation of a patient for medical procedures and long-term prophylaxis allow one to reduce the risk of anaphylaxis in patients with mastocytosis. nadwrażliwość i alergia na leki u chorych na mastocytozę Drug hypersensitivity reactions and allergy in patients with mastocytosis

show abstract

Pediatric Mastocytosis: A Review of the Literature

Cited by 55 publications

References 28 publications

Solitary Hepatic Eosinophilic Granuloma Accompanied by Eosinophilia Without Parasitosis: Report of a Case

Solitary Hepatic Eosinophilic Granuloma Accompanied by Eosinophilia Without Parasitosis: Report of a Case

An Unusual Trigger for Cutaneous Mastocytosis: The Insulin Pump

Drug hypersensitivity reactions and allergy in patients with mastocytosis

Contact Info

Product

Resources

About