Pediatric Outcome After Maternal Cancer Diagnosed During Pregnancy

Neonatal outcomes of pregnancy‐associated breast cancer: Population‐based study on 11 million births

“…Although some of the chemotherapy drugs are known to be cardio-toxic to the mother, when evaluating the fetus for cardiac findings, the findings were normal. 18,19 Also, the latest publications did not find longterm cognitive adverse effects in babies that were exposed to chemotherapy when compared with those who were not. [18][19][20] Several studies have shown that chemotherapy given to breast cancer patients during pregnancy resulted in malformation rates not greater than that in the general population.…”

“…18,19 Also, the latest publications did not find longterm cognitive adverse effects in babies that were exposed to chemotherapy when compared with those who were not. [18][19][20] Several studies have shown that chemotherapy given to breast cancer patients during pregnancy resulted in malformation rates not greater than that in the general population. 5,6,8,20 Treatment information was not available in the HCUP-NIS data base; hence, we could not differentiate between patients who received or did not receive chemotherapy and/or surgery during pregnancy and as a result, we…”

“…Preterm births have been previously associated with breast cancer during pregnancy, which is consistent with our findings. 19 A study by Loibl et al evaluated whether this increased risk of preterm births may be associated with the breast cancer treatments received. They found that prematurity was not related to the use of chemotherapy during pregnancy, although they appeared to underestimate the rate of preterm delivery, which may be attributed to the small sample size of their study.…”

Psychiatric disorders among children of parents with cancer: A Swedish register‐based matched cohort study

“…In relation to a maternal cancer during pregnancy, the fetus might be exposed to cancer-induced hormonal and nutritional changes, chronic inflammation, and the toxic effects of cancer treatment. 11,28 Our null finding regarding maternal cancer during pregnancy might provide evidence that maternal cancer in complication with pregnancy is not likely to impact significantly the child's future risk of psychiatric disorder. In relation to a paternal cancer during pregnancy, the fetuses might be exposed to severe maternal stress as a cancer disease brings about severe psychological stress for the patients and the spouses.…”

Successful molecular targeted treatment of AML in pregnancy with Azacitidine and Sorafenib with no adverse fetal outcomes

“…Experience suggests that past the first trimester, cytotoxic chemotherapy for AML can be safely given with stringent fetal monitoring (Milojkovic & Apperley, 2014;Ali et al, 2015). A recent study (Amant et al, 2015) suggested that paediatric developmental outcomes were not inferior in women exposed to a heterogenous group of chemotherapy regimens after the second trimester compared to normal controls.…”