Pediatric parechovirus infections

Esposito, Susanna; Rahamat‐Langendoen, Janette; Ascolese, Beatrice; Senatore, Laura; Castellazzi, Luca; Niesters, Hubert G. M.

doi:10.1016/j.jcv.2014.03.003

Cited by 112 publications

(96 citation statements)

References 43 publications

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“…Another patient experienced abdominal pain and rash, a combination which has been documented in a case series of eight infants with HPeV infection [6]. In two patients within our case series, cerebrospinal studies were positive for HPeV despite normal white blood cell counts in the CSF, which is consistent with previous reports of HPeV central nervous system infections [7]. Based on our observations in this study, a septic infant with these characteristic laboratory findings should be assessed for viral infections in the CNS during initial workup while undergoing treatment for presumptive bacterial disease.…”

Section: Discussionsupporting

confidence: 90%

“…Among those infants, cranial ultrasound and neonatal MRI confirmed white matter changes in a majority of the infants with gliosis noted on later MRI. Outcome varied in this cohort; most children had no long term sequelae, but those who did had significant poor outcomes such as cerebral palsy, learning problems at school age, and epilepsy [7]. All neonates in our case series were referred to developmental follow-up services and imaging at a later date.…”

Section: Case Presentationmentioning

confidence: 96%

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Parechovirus Sepsis and Meningitis in a Neonatal Intensive Care Unit

Fritz¹,

Karody²

2015

J Neuroinfect Dis

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The majority of febrile neonates have negative bacterial cultures and presumed viral infections. During November 2014, four febrile neonates in southeastern Wisconsin required intensive care admission for human parechovirus (HPeV) infection in the blood and/or cerebral spinal fluid (CSF). Both vertical and horizontal transmission led to disease, and a variety of signs and symptoms, including tachycardia, hypotension, neutropenia, rash and irritability accompanied fever. All neonates recovered clinically, although concern for neurodevelopmental delay remains for those with meningoencephalitis. This case series describes the presentation and short-term outcomes of neonates requiring intensive care for HPeV infections.

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Section: Discussionsupporting

confidence: 90%

Section: Case Presentationmentioning

confidence: 96%

Parechovirus Sepsis and Meningitis in a Neonatal Intensive Care Unit

Fritz¹,

Karody²

2015

J Neuroinfect Dis

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“…Human parechovirus is a common enteric pathogen associated with gastroenteritis, respiratory illness and, rarely, more severe diseases such as myocarditis, encephalitis, pneumonia, meningitis and flaccid paralysis (Esposito et al, 2014). Ljungan virus and Sebokele virus were isolated from rodents in Sweden (Niklasson et al, 1999) and the Central African Republic (Joffret et al, 2013), respectively.…”

Section: Identification Of a Novel Picornavirusmentioning

confidence: 99%

Metagenomic analysis of the shrew enteric virome reveals novel viruses related to human stool-associated viruses

Sasaki

Orba

Ueno

et al. 2015

Journal of General Virology

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Shrews are small insectivorous mammals that are distributed worldwide. Similar to rodents, shrews live on the ground and are commonly found near human residences. In this study, we investigated the enteric virome of wild shrews in the genus Crocidura using a sequence-independent viral metagenomics approach. A large portion of the shrew enteric virome was composed of insect viruses, whilst novel viruses including cyclovirus, picornavirus and picorna-like virus were also identified. Several cycloviruses, including variants of human cycloviruses detected in cerebrospinal fluid and stools, were detected in wild shrews at a high prevalence rate. The identified picornavirus was distantly related to human parechovirus, inferring the presence of a new genus in this family. The identified picorna-like viruses were characterized as different species of calhevirus 1, which was discovered previously in human stools. Complete or nearly complete genome sequences of these novel viruses were determined in this study and then were subjected to further genetic characterization. Our study provides an initial view of the diversity and distinctiveness of the shrew enteric virome and highlights unique novel viruses related to human stool-associated viruses.

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“…The infections are common: according to the Division of Viral Diseases of the Centers for Disease Control and Prevention (CDC) EVs cause 10-15 million infections and tens of thousands hospitalizations annually in the USA alone (www.cdc.gov/ non-polio-enterovirus/about/overview.html, updated on 19 September 2014). Human EV and HPeV species are responsible for about 80 % of aseptic meningitis cases [36] and 11 % of reported encephalitis cases [37]. Several types of EV can trigger myelitis with limb paralysis [38].…”

Section: Neurotropic Picornaviruses In Focusmentioning

confidence: 99%

“…Outbreaks of HPeV-3 usually occur in the summer/autumn seasons and have a distinct biennial pattern [96,98]. They have been documented in Europe [99], North America [100], Asia [101] and Australia [102], and are regularly associated with a variety of clinical presentations, from mild gastrointestinal or respiratory illness to life-threatening conditions in neonates [36,96,103]. It can cause systemic infections with possible neurological involvement in infants, which are collectively described as 'sepsis-like illnesses' [98,99,104].…”

Section: Human Parechovirusmentioning

confidence: 99%

Human picornaviruses associated with neurological diseases and their neutralization by antibodies

Anastasina

Domanska

Palm

et al. 2017

Journal of General Virology

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Picornaviruses are the most commonly encountered infectious agents in mankind. They typically cause mild infections of the gastrointestinal or respiratory tract, but sometimes also invade the central nervous system. There, they can cause severe diseases with long-term sequelae and even be lethal. The most infamous picornavirus is poliovirus, for which significant epidemics of poliomyelitis were reported from the end of the nineteenth century. A successful vaccination campaign has brought poliovirus close to eradication, but neurological diseases caused by other picornaviruses have increasingly been reported since the late 1990s. In this review we focus on enterovirus 71, coxsackievirus A16, enterovirus 68 and human parechovirus 3, which have recently drawn attention because of their links to severe neurological diseases. We discuss the clinical relevance of these viruses and the primary role of humoral immunity in controlling them, and summarize current knowledge on the neutralization of such viruses by antibodies.

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Pediatric parechovirus infections

Cited by 112 publications

References 43 publications

Parechovirus Sepsis and Meningitis in a Neonatal Intensive Care Unit

Parechovirus Sepsis and Meningitis in a Neonatal Intensive Care Unit

Metagenomic analysis of the shrew enteric virome reveals novel viruses related to human stool-associated viruses

Human picornaviruses associated with neurological diseases and their neutralization by antibodies

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