Pediatric renal transplantation: 5 years experience from Jaslok Hospital, Mumbai

Sathe, Kiran P; Joshi, S. S.; Mehta, Kumud

doi:10.1016/j.ijt.2014.01.016

Cited by 4 publications

(7 citation statements)

References 7 publications

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“…This could also be an image of social security skewed toward the male child. Similar findings have been reported from neighborhood . Parents were the main donors in 91.3% cases.…”

Section: Discussionsupporting

confidence: 88%

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Pediatric kidney transplantation in Nepal

Kafle

Poudyal²,

Chalise

et al. 2019

Pediatric Transplantation

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Background Success in pediatric kidney transplantation is great achievement for the emerging countries. This report is the first of its kind from Nepal. It demonstrates the status of pediatric kidney transplantation in Nepal. Methods This is a retrospective review of transplants done in Tribhuvan University Teaching Hospital, Kathmandu, Nepal. Living donor kidney transplant recipients ≤17 years transplanted till September 2018 were included. Demographic data, renal function, rejections, and other complications recorded in the charts were noted. Descriptive analysis was done in September 2018. Results A total of 517 living donor kidney transplants were done till September 2018 since August 2008. Twenty‐three were ≤17 years. Eighteen (78.26%) were male. Mean ± SD age was 15.35 ± 1.7 years, and weight was 41.8 ± 9.8 kg. One received ABO‐incompatible transplantation. Fifteen (65.22%) donors were female, 14 (60.87%) were mothers, and seven were fathers (30.43%). Mean donor age was 40.21 ± 8 years. Patient and graft survival at 1 year were 100% and 89.2%, respectively. One patient died on dialysis in second year after graft failure due to FSGS. One is on dialysis after losing graft to oxalate nephropathy. Three (13.3%) had biopsy‐proven acute rejections. Two had acute cellular rejection, and 1 had antibody‐mediated rejection. Conclusions Children from poor countries are also entitled to the benefits of medical advancements.

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“…This could also be an image of social security skewed toward the male child. Similar findings have been reported from neighborhood . Parents were the main donors in 91.3% cases.…”

Section: Discussionsupporting

confidence: 88%

“…Total number of patients is not that large, but we have demonstrated comparable survival outcome results. Table shows comparison of our results with similar publications from India …”

Section: Discussionmentioning

confidence: 75%

Pediatric kidney transplantation in Nepal

Kafle

Poudyal²,

Chalise

et al. 2019

Pediatric Transplantation

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“…Other centers from India have comparable mean recipient age in their studies. [ 4 8 ] Emiroglu et al . had similar age distribution of the recipient population (14.9 ± 2.2 years).…”

Section: Discussionmentioning

confidence: 99%

“…Small-sized recipients, i.e., age <10 years and weight <20 kg are considered as high-risk category for renal transplantation considering the technical challenges experienced due to the small sizes of vascular structures. [ 8 ] We had only two recipients with weight <20 kg and no recipient <10 years of age.…”

Section: Discussionmentioning

confidence: 99%

Outcome and complications of living donor pediatric renal transplantation: Experience from a tertiary care center

et al. 2017

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Introduction:We retrospectively reviewed the patient characteristics, outcome, and complications of renal transplantation in pediatric age group performed at our center and compared the results with various centers in India and other developed countries.Materials and Methods:Patients younger than eighteen years of age who underwent renal transplantation from 2003 to 2014 at our institute were reviewed. Demographic data of the transplant recipients and donors, etiology of ESRD, mode of dialysis, surgical details of renal transplantation, immunosuppression, medical and surgical complications, and post-transplant follow-up were assessed. Graft survival was determined at 1, 3 and 5 years post-transplant. All data collected were entered into Microsoft excel program and analyzed using SPSS 20. Kaplan–Meier method was applied to determine the graft survival at 1, 3, and 5 years. The log-rank test was applied to test the statistical significance of the difference in survival between groups.Results:Thirty-two children underwent transplantation comprising of 18 females and 14 males. The mean age was 14.5 years (range 10–17 years). The primary cause of renal failure was glomerular diseases in 53% (17/32) of patients. Seventeen postsurgical complications were noted in our series. Two grafts were lost over a follow-up of 5 years. The 1, 3, and 5 year graft survival rates were 96.7%, 92.9%, and 85%, respectively. There was no mortality.Conclusion:The etiology of ESRD in our region is different from that of developed countries. The mean age at which children undergo renal transplantation is higher. Graft survival at our center is comparable to that of developed nations. Renal transplantation can be safely performed in children with ESRD.

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“…( 7,8) Initially it is mentioned in the text "Gharguti Aushadhe" and it is also called as Kombadnakhi, Bichava, Nirvishi and Waghchavdi. (9,10) The rhizomes of this herb being used as a folklore remedy for the treatment of Shotha, Shula, Arbuda etc. successfully.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of In Vitro Anti-Cancer Activity of Kukkutanakhi Guggula on Liver, Prostrate, Ovary and Renal Cancer

Khan¹,

Sathe²,

Rathi³

2020

IJAM

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The medicines prepared by using exudates of Commiphora mukul (Stocks) Hook. are described in Ayurveda under Guggula Kalpana which are among such valuable dosage forms. According to retrospective literary review, the combination of Kukkutnaki (Aspidium cicutarium Sw.) and purified Guggula(Commiphora mukul (Stocks) Hook.) was first mentioned in the book Chikitsa pradeep named as Kukkutnaki Guggula. Since last 3 decades, it was documented as an herbal drug which is used for cysts, goiter, tumors, tonsillitis, abscess, mansvaha strotas ailments, which are burning issues worldwide. Due to its observed clinical efficacy in Arbuda (~Cancer), the current in-vitro anticancer study was conducted with an aim to check its anticancer effect on human hepatoma cell line-HEPG2 of Liver; PC-3 and DU145 cancer cell lines of Prostate; Ovcar-3, A2780, SK-OV-3, PA-1 cancer cell lines of Ovary and ACHN renal cancer cell line of Kidney. The current in vitro study was conducted at ACTREC, Kharghar, Navi Mumbai. The selected cancer cell lines were procured from ATCC, USA and NCCS Pune. The Sulforhodamine B (SRB) Assay protocol was followed to observe the activity of the study drug. The positive control was Adriamycin in the study. The growth curve graphs were plotted and LC50, GI50, TGI values were calculated. Kukkutnakhi Guggula was found safe for oral administration, non- toxic at cellular level (LC50 values were > 160) and have moderate activity on HEPG2, Ovcar-3, DU145, ACHN cancer cell lines and had shown negligible activity on A2780, SK-OV-3, PA-1 and PC-3 cell lines. This work provides scope to study its effect on targeted cancers, specific in vivo scientific studies and human clinical trials for further researchers.

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Pediatric renal transplantation: 5 years experience from Jaslok Hospital, Mumbai

Cited by 4 publications

References 7 publications

Pediatric kidney transplantation in Nepal

Pediatric kidney transplantation in Nepal

Outcome and complications of living donor pediatric renal transplantation: Experience from a tertiary care center

Evaluation of In Vitro Anti-Cancer Activity of Kukkutanakhi Guggula on Liver, Prostrate, Ovary and Renal Cancer

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