Pediatric Solid Tumors and Second Malignancies: Characteristics and Survival Outcomes

Vasudevan, Vanitha; Cheung, Michael C.; Yang, Relin; Zhuge, Ying; Fischer, Anne C.; Koniaris, Leonidas G.; Sola, Juan E.

doi:10.1016/j.jss.2009.05.030

Cited by 36 publications

(26 citation statements)

References 18 publications

(33 reference statements)

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“…• [4,[13][14][15], which account for 35% of the cases reported here. Second, we report on a recent (1987)(1988)(1989)(1990)(1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004) [4,[13][14].…”

Section: Clinical Classificationmentioning

confidence: 82%

Second Malignant Neoplasms Following Childhood Cancer: A Study of a Recent Cohort (1987–2004) from the Childhood Cancer Registry of The Rhône-Alpes Region (ARCERRA) in France

Berger

Casagranda

Mialou

et al. 2011

Pediatric Hematology and Oncology

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Studies of second malignant neoplasms (SMNs) in childhood are generally conducted in old cohorts. The aim of this study was to determine the actual incidence of all SMNs in a recent cohort. The authors studied a cohort of 2907 children included in the population-based Childhood Cancer Registry of the Rhône-Alpes Region for a first cancer diagnosed between 1987 and 2004. Total follow-up was 22,722 person-years, with a median follow-up of 9.8 years (range, 00.0-22.8 years). Fifty-four SMNs were reported in 52 patients. Overall median latency was 5.9 years. Cumulative incidence rates were 2.2% at 10 years and 3.9% at 15, with an overall standardized incidence ratio (SIR) of 13.9 (95% confidence interval [CI], 10.4-18.3) and absolute excess risk of 2.2. The SMNs were 12 thyroid carcinomas (SIR 57.1); 9 bone tumors (SIR 32.0); 8 leukemias (SIR 11.9); 5 lymphomas, all related to Epstein-Barr virus following allograft, (SIR 6.7); 5 CNS tumors (SIR 10.5); 4 soft tissue sarcomas (SIR 17.4); 4 carcinomas (no breast cancer); and 7 other cancers. Twelve SMNs appeared after total body irradiation, 16 after focal radiotherapy, and 8 leukemias after chemotherapy. The risk of secondary cancer was highest after retinoblastomas (SIR 41.8), Hodgkin lymphomas (SIR 20.8), leukemias (SIR 18.4), soft tissue sarcomas, CNS tumors, and bone tumors. These recent cohort findings show, on one hand, a high incidence of SMNs but do not capture breast cancers because of the relatively short follow-up and, on the other hand, a different distribution of first and second cancers.

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Section: Clinical Classificationmentioning

confidence: 82%

Second Malignant Neoplasms Following Childhood Cancer: A Study of a Recent Cohort (1987–2004) from the Childhood Cancer Registry of The Rhône-Alpes Region (ARCERRA) in France

Berger

Casagranda

Mialou

et al. 2011

Pediatric Hematology and Oncology

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“…Galloway et al emphasized good outcomes in their series; however, there were predominancy of meningiomas, followed by glial tumors and medulloblastomas [8]. Vasudevan et al [19] reported about the outcomes, indicating 10 year survival rates of 13.6 % [19]. Morris et al [13] designated formation of a new neoplasm as the second leading cause of mortality (first one being recurrence of the initial tumor) in cancer survivors after 5 years.…”

Section: Discussionmentioning

confidence: 99%

De novo formation of brain tumors in pediatric population following therapeutic cranial irradiation

et al. 2015

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“…[23][24][25] In general, cancer patients are also more prone to developing second malignancies. 26,27 Furthermore, when selecting a treatment option, understanding physiologic characteristics of the lesion can be helpful for treatment optimization. Lesion sensitivity to radiation therapy and chemotherapy, for example, is often a consideration in the management of metastatic lesions.…”

Section: Discussionmentioning

confidence: 99%

Characterizing Hypervascular and Hypovascular Metastases and Normal Bone Marrow of the Spine Using Dynamic Contrast-Enhanced MR Imaging

Khadem¹,

Karimi²,

Peck³

et al. 2012

AJNR Am J Neuroradiol

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Pediatric Solid Tumors and Second Malignancies: Characteristics and Survival Outcomes

Cited by 36 publications

References 18 publications

Second Malignant Neoplasms Following Childhood Cancer: A Study of a Recent Cohort (1987–2004) from the Childhood Cancer Registry of The Rhône-Alpes Region (ARCERRA) in France

Second Malignant Neoplasms Following Childhood Cancer: A Study of a Recent Cohort (1987–2004) from the Childhood Cancer Registry of The Rhône-Alpes Region (ARCERRA) in France

De novo formation of brain tumors in pediatric population following therapeutic cranial irradiation

Characterizing Hypervascular and Hypovascular Metastases and Normal Bone Marrow of the Spine Using Dynamic Contrast-Enhanced MR Imaging

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