Pedicled buccal fat pad flap for intraoral malignant defects: A series of 29 cases

Chakrabarti, Jayanta; Tekriwal, Rohit; Ganguli, Arun; Ghosh, Supriti; Mishra, P K

doi:10.4103/0970-0358.53010

Cited by 24 publications

(11 citation statements)

References 19 publications

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“…The nature of healing of the pedicled BFP in maxillofacial surgery has been widely reported, and the main mechanism is fibrosis and fast epithelialization of the graft. [ 16 21 22 23 ]…”

Section: Discussionmentioning

confidence: 99%

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The use of Buccal fat pad free graft in regenerative treatment of peri-implantitis: A new and predictable technique

Kablan

2015

Ann Maxillofac Surg

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Introduction:Peri-implantitis is a common condition, but no particular treatment protocol has shown to be definitively effective. Fat tissue in the oral cavity is widely available and easily accessed. The aim of the current study is to present a novel technique in the treatment of peri-implant lesions, utilizing a free fat tissue graft from the buccal fat pad (BFP).Patients and Methods:Free fat graft (FFG) was harvested from the BFP in eight patients and used with bone substitutes to regenerate 22 peri-implant lesions. Mechanical debridement of the implants surface and the granulation tissue were made with curettes or with Er: YAG laser. Clinical parameters such as plaque index, bleeding on probing, pocket depth, gingival recession, and the clinical attachment level were recorded as a baseline during the follow-up period. In addition, radiological evaluation was made preoperative during the follow-up period.Results:The donor site of the free fat graft was healed without cosmetic defect in all patients. Twenty-two peri-implant lesions were followed up for 12 months. Bleeding on probing and the pocket depth were significantly improved, and the clinical attachment level was achieved and maintained during the follow-up period due to the fibrous healing of the free fat graft. Satisfactory esthetic and functional outcomes of the treated implants were achieved and maintained.Conclusions:Free buccal fat graft heals by fibrosis. The fibrotic tissue adheres strongly to the implant surface and with stand the recurrence of the peri-implant lesion and provides stable and predictable outcome.

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“…The nature of healing of the pedicled BFP in maxillofacial surgery has been widely reported, and the main mechanism is fibrosis and fast epithelialization of the graft. [ 16 21 22 23 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 12 13 14 ] Egyedi[ 15 ] was the first to report the use of the BFP as a pedicled graft in 1977; since then, several publications have described the different applications of the BFP as a pedicled graft. [ 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 ]…”

Section: Introductionmentioning

confidence: 99%

The use of Buccal fat pad free graft in regenerative treatment of peri-implantitis: A new and predictable technique

Kablan

2015

Ann Maxillofac Surg

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“…14 The buccal fat pad flaps are used in the reconstruction of the periorbital area, 15 for the repair of congenital oro-antral and/or oro-nasal disorders, 16 and for congenital cleft palate repair. 17 More recently, they have also been used for the closure of oro-antral communications 18,19 and treatment of oral submucous fibrosis, 20,21 intraoral malignant defects, 22 and cheek mucosa defects. 23 …”

Section: Introductionmentioning

confidence: 99%

Mesenchymal Stem Cells from Bichat's Fat Pad:In VitroComparison with Adipose-Derived Stem Cells from Subcutaneous Tissue

Broccaioli

Niada

Rasperini

et al. 2013

BioResearch Open Access

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Adipose-derived stem/stromal cells (ASCs) are progenitor cells used in bone tissue engineering and regenerative medicine. Since Bichat's fat pad is easily accessible for dentists and maxillo-facial surgeons, we compared the features of ASCs from Bichat's fat pad (BFP-ASCs) with human ASCs from subcutaneous adipose tissue (SC-ASCs). BFP-ASCs isolated from a small amount of tissue were characterized for their stemness and multidifferentiative ability. They showed an important clonogenic ability and the typical mesenchymal stem cell immunophenotype. Moreover, when properly induced, osteogenic and adipogenic differentiation markers, such as alkaline phosphatase activity, collagen deposition and lipid vacuoles formation, were promptly observed. Growth of both BFP-ASCs and SC-ASCs in the presence of human serum and their adhesion to natural and synthetic scaffolds were also assessed. Both types of ASCs adapted rapidly to human autologous or heterologous sera, increasing their proliferation rate compared to standard culture condition, and all the cells adhered finely to bone, periodontal ligament, collagen membrane, and polyglycol acid filaments that are present in the oral cavity or are commonly used in oral surgery. At last, we showed that amelogenin seems to be an early osteoinductive factor for BFP-ASCs, but not SC-ASCs, in vitro. We conclude that Bichat's fat pad contains BFP-ASCs with stemness features that are able to differentiate and adhere to biological supports and synthetic materials. They are also able to proliferate in the presence of human serum. For all these reasons we propose BFP-ASCs for future therapies of periodontal defects and bone regeneration.

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“…Since 1977, the BFP has been used in surgery for the treatment of congenital oroantral and/or oronasal diseases [15], congenital cleft palate repair [16], oral submucous fibrosis [17,18], intraoral malignant defects [19], and cheek mucosa defects [15,20]. In addition, BFP is a discarded tissue of plastic surgery for cheek reduction.…”

Section: Introductionmentioning

confidence: 99%

Porcine adipose-derived stem cells from buccal fat pad and subcutaneous adipose tissue for future preclinical studies in oral surgery

et al. 2013

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IntroductionAdipose-derived stem cells (ASCs) are progenitor cells used in bone tissue engineering and regenerative medicine. Despite subcutaneous adipose tissue being more abundant, the buccal fat pad (BFP) is easily accessible for dentists and maxillofacial surgeons. For this reason, considering the need for preclinical study and the swine as an optimal animal model in tissue engineering applications, we compared the features of porcine ASCs (pASCs) from both tissue-harvesting sites.MethodsASCs were isolated from interscapular subcutaneous adipose tissue (ScI) and buccal fat pads of six swine. Cells were characterized for their stemness and multipotent features. Moreover, their osteogenic ability when cultured on titanium disks and silicon carbide-plasma-enhanced chemical vapor-deposition fragments, and their growth in the presence of autologous and heterologous serum were also assessed.ResultsIndependent of the harvesting site, no differences in proliferation, viability, and clonogenicity were observed among all the pASC populations. Furthermore, when induced toward osteogenic differentiation, both ScI- and BFP-pASCs showed an increase of collagen and calcified extracellular matrix (ECM) production, alkaline phosphatase activity, and osteonectin expression, indicating their ability to differentiate toward osteoblast-like cells. In addition, they differentiated toward adipocyte-like cells, and chondrogenic induced pASCs were able to increase glycosaminoglycans (GAGs) production over time. When cells were osteoinduced on synthetic biomaterials, they significantly increased the amount of calcified ECM compared with control cells; moreover, titanium showed the osteoinductive effect on pASCs, also without chemical stimuli. Finally, these cells grew nicely in 10% FBS, and no benefits were produced by substitution with swine serum.ConclusionsSwine buccal fat pad contains progenitor cells with mesenchymal features, and they also osteo-differentiate nicely in association with synthetic supports. We suggest that porcine BFP-ASCs may be applied in preclinical studies of periodontal and bone-defect regeneration.

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Pedicled buccal fat pad flap for intraoral malignant defects: A series of 29 cases

Cited by 24 publications

References 19 publications

The use of Buccal fat pad free graft in regenerative treatment of peri-implantitis: A new and predictable technique

The use of Buccal fat pad free graft in regenerative treatment of peri-implantitis: A new and predictable technique

Mesenchymal Stem Cells from Bichat's Fat Pad:In VitroComparison with Adipose-Derived Stem Cells from Subcutaneous Tissue

Porcine adipose-derived stem cells from buccal fat pad and subcutaneous adipose tissue for future preclinical studies in oral surgery

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