PEG-fibrin conjugates: the PEG impact on the polymerization dynamics

Bakulina, Alesia; Musina, Guzel R.; Gavdush, A. A.; Efremov, Yuri M.; Komandin, G. A.; Vosough, Massoud; Shpichka, Anastasia; Zaytsev, Kirill; Timashev, Peter

doi:10.1039/d2sm01504h

Cited by 2 publications

(1 citation statement)

References 51 publications

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“… 79 A widely used hybrid hydrogel is methacryloyl-modified gelatin (GelMA), which is a chemically modified natural material, 72 while PEG crosslinked fibrinogen, or collagen, is a combination of natural and synthetic matrices. 73 , 74 Hybrid hydrogels can not only possess the multi-tuneable mechanical properties of synthetic hydrogels by adjusting chemical parameters but also preserve the biocompatibility and bioactivity of natural hydrogels. 80 …”

Section: Hydrogelmentioning

confidence: 99%

Hydrogel Loaded with Components for Therapeutic Applications in Hypertrophic Scars and Keloids

Zhong,

Zhang,

et al. 2024

IJN

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Hypertrophic scars and keloids are common fibroproliferative diseases following injury. Patients with pathologic scars suffer from impaired quality of life and psychological health due to appearance disfiguration, itch, pain, and movement disorders. Recently, the advancement of hydrogels in biomedical fields has brought a variety of novel materials, methods and therapeutic targets for treating hypertrophic scars and keloids, which exhibit broad prospects. This review has summarized current research on hydrogels and loaded components used in preventing and treating hypertrophic scars and keloids. These hydrogels attenuate keloid and hypertrophic scar formation and progression by loading organic chemicals, drugs, or bioactive molecules (such as growth factors, genes, proteins/peptides, and stem cells/exosomes). Among them, smart hydrogels (a very promising method for loading many types of bioactive components) are currently favoured by researchers. In addition, combining hydrogels and current therapy (such as laser or radiation therapy, etc.) could improve the treatment of hypertrophic scars and keloids. Then, the difficulties and limitations of the current research and possible suggestions for improvement are listed. Moreover, we also propose novel strategies for facilitating the construction of target multifunctional hydrogels in the future.

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