PEG-modified gold nanorods with a stealth character for in vivo applications

Cellular Uptake, Intracellular Trafficking and Biological Responses of Gold Nanoparticles

“…Synthesized gold nanorods (GNRs) contain a large amount of CTAB molecules in the solution, which exhibit high cytotoxicity. [29][30][31] CTAB molecules develop bilayers on the surface of GNRs. Though we can remove most of free CTAB from solution, repeated centrifugation may cause irreversible aggregation of GNRs.…”

Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice

“…Subcutaneous squamous cell carcinoma xenografts were grown in nude (nu/nu) mice and particles were selectively delivered to tumors by both direct and intravenous injection. Thiolated poly (ethylene) glycol (PEG5000) was covalently bound to the gold nanorod surface to increase biocompatibility [77][78][79][80], suppress immunogenic responses, and to decrease adsorption to the negatively charge luminal surface of blood vessels. Near-infrared PPTT was performed extracorporally using a small, portable, inexpensive, continuous wave diode laser.…”

Gold nanostars for efficient in vitro and in vivo real-time SERS detection and drug delivery via plasmonic-tunable Raman/FTIR imaging

“…14,15 For example, Hirsch et D al. have employed nanoshells to tune a wavelength of gold nanoparticles at 720 nm to achieve photothermal ablation of tumor cells by irradiation using near-infrared laser light in vivo.…”

“…16 Gold nanostars, star-shaped gold nanoparticles, have exceptional optical properties. [17][18][19][20] They display two surface plasmon bands consistent to the transverse and longitudinal surface plasmon bands in the visible (520 nm) and the near-infrared regions, respectively 15 Thus, gold nanostars are special materials with an intense surface plasmon band that affords absorption, fluorescence [21][22][23] and light scattering 24,25 in the near-infrared region, inducing two-photon luminescence phenomena. 26 Hexadecyltrimethylammonium bromide (CTAB) is a common material for gold nanostar synthesis.…”