PEGylated Bilirubin-coated Iron Oxide Nanoparticles as a Biosensor for Magnetic Relaxation Switching-based ROS Detection in Whole Blood

Lee, Dong Yun; Kang, Sukmo; Lee, Yonghyun; Kim, Jin Yong; Yoo, Dohyun; Jung, Woong; Lee, So‐Young; Jeong, Yong Yeon; Lee, Kwangyeol; Jon, Sangyong

doi:10.7150/thno.39662

Cited by 40 publications

(11 citation statements)

References 36 publications

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“…In the recently reported study, ROS detection was performed by a dual-mode biosensor using both magnetic relaxation switching (MRSw) and fluorescence-based detection methods [84]. For MRSw based detection, initially, PEGylated bilirubin (PEG-BR)-coated SPIONs (PEG-BR@SPIONs) were developed by simple sonication via ligand exchange which was later coated with a near infra-red (NIR) fluorescent dye.…”

Section: Miscellaneous Nanosensorsmentioning

confidence: 99%

“…The reported studies demonstrated that nanoparticle-based biosensors provide a rapid, specific and sensitive means of diagnosis of a broad range of biomarkers and infectious pathogen detection. Further, a recent study by Lee et al (2020) showed that dual methods of nanosensors could be combined for ROS detection [84]; however, it remains indefinable for combination for different nanosensor mechanisms in the detection of multiple biomarkers. Reliance on a single biomarker for sepsis is challenging as commonly used biomarkers such as CRP and PCT display altered expression in other diseases such as trauma, surgery, and heatstroke [15].…”

Section: Future Prospectives and Conclusionmentioning

confidence: 99%

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Advances in sepsis diagnosis and management: a paradigm shift towards nanotechnology

2021

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Sepsis, a dysregulated immune response due to life-threatening organ dysfunction, caused by drug-resistant pathogens, is a major global health threat contributing to high disease burden. Clinical outcomes in sepsis depend on timely diagnosis and appropriate early therapeutic intervention. There is a growing interest in the evaluation of nanotechnology-based solutions for sepsis management due to the inherent and unique properties of these nano-sized systems. This review presents recent advancements in nanotechnology-based solutions for sepsis diagnosis and management. Development of nanosensors based on electrochemical, immunological or magnetic principals provide highly sensitive, selective and rapid detection of sepsis biomarkers such as procalcitonin and C-reactive protein and are reviewed extensively. Nanoparticle-based drug delivery of antibiotics in sepsis models have shown promising results in combating drug resistance. Surface functionalization with antimicrobial peptides further enhances efficacy by targeting pathogens or specific microenvironments. Various strategies in nanoformulations have demonstrated the ability to deliver antibiotics and anti-inflammatory agents, simultaneously, have been reviewed. The critical role of nanoformulations of other adjuvant therapies including antioxidant, antitoxins and extracorporeal blood purification in sepsis management are also highlighted. Nanodiagnostics and nanotherapeutics in sepsis have enormous potential and provide new perspectives in sepsis management, supported by promising future biomedical applications included in the review.

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Section: Miscellaneous Nanosensorsmentioning

confidence: 99%

Section: Future Prospectives and Conclusionmentioning

confidence: 99%

Advances in sepsis diagnosis and management: a paradigm shift towards nanotechnology

2021

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“…These particles have been used to detect a variety of biomarkers via magnetic relaxation switching (MRSw). However, there has never been a documented MRSw-based biosensor for ROS [ 43 ]. Research shows how PEGylated bilirubin (PEG-BR)-coated SPIONs were made via simple sonication and ligand exchange.…”

Section: Reviewmentioning

confidence: 99%

Sepsis Management, Controversies, and Advancement in Nanotechnology: A Systematic Review

Choudhary¹

2022

Cureus

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Sepsis is a potentially dangerous infection that requires prompt identification and treatment. Emergency medicine physicians must grasp the clinical signs and laboratory results of direct and indirect organ failure, the source of infection management, and the criteria for treating sepsis and septic shock. The pathogenesis of sepsis is connected to inflammation and an excess of reactive oxygen and nitrogen species, which activate the pathogen-associated molecular pattern (PAMP)-pattern recognition receptor (PRR) and damageassociated molecular pattern (DAMP)-PRR signaling pathways. The development of rapid, sensitive, and precise techniques for sepsis diagnosis might be aided by nanotechnology, a part of nanomedicine. Nanoparticles (NPs) such as magnetic NPs, gold NPs, fluorescent (silica and quantum dots), and lipid-based NPs have all been discussed to contribute to the detection of sepsis-related microbial infections. Because of the intrinsic and unique features of these nano-sized systems, researchers are evaluating nanotechnologybased alternatives for sepsis control. Recent advances in nanotechnology-based technologies for sepsis detection and management are discussed in this study.Databases (PubMed, Medline, PMC, Google Scholar) were used to source various studies that were carried out on sepsis in terms of assessment, types, diagnosis, and treatment controversies, with more attention being given with a focus on the most recent data, principles, and management guidelines. Priority was also given to studies published within the last 11 years, using keywords such as "sepsis guidelines," "sepsis clinical," "septic risk factors," "sepsis and nano technology," "nano particles," "sepsis controversies," and "nano diagnostic" in the search. After a filtration process, the eight most relevant studies were selected to be included in this review. The filtration process included the use of both inclusion and exclusion criteria. The excluded studies were pediatric populations, obstetrical populations, and nanotechnology advancements dealing with other fields not relating to sepsis. The selected studies were also undertaken through a quality appraisal process using corresponding assessment tools. The selected articles were all highly informative about sepsis and the processes of diagnosis and treatment that are currently in use as well as those that are still being developed or implemented. Furthermore, we look at how nanomedicine in the application of nanomaterials can be employed to efficiently manage sepsis.

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“…Therefore, we described only silica and PEGylation strategies in this section, since our group has contributed to this field. Thermal decomposition PEG MRI [190][191][192] MRI/SPECT ( 99m Tc) [193] MRI/SPECT ( 125 I) [106,194] MRI/PET ( 68 Ga) [195] MRI/PET ( 64 Cu) [196] MRI/PET ( 71 As) [197] SPECT ( 99m Tc) [174] [198] Hydroxyl−PEG−Phosphonic Acid [199] DSPE-mPEG 2000 /DSPE-mPEG 2000 amine MRI/PET ( 68 Ga) [200] Silica MRI [201,202] MRI/US [203] Mesoporous Silica MRI [202,204] MRI/Fluorescence Imaging [190] Silica MRI/Optical (FITC) [205] Hydrothermal…”

Section: Synthetic Biocompatible Polymersmentioning

confidence: 99%

Imaging Constructs: The Rise of Iron Oxide Nanoparticles

et al. 2021

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Over the last decade, an important challenge in nanomedicine imaging has been the work to design multifunctional agents that can be detected by single and/or multimodal techniques. Among the broad spectrum of nanoscale materials being investigated for imaging use, iron oxide nanoparticles have gained significant attention due to their intrinsic magnetic properties, low toxicity, large magnetic moments, superparamagnetic behaviour and large surface area—the latter being a particular advantage in its conjunction with specific moieties, dye molecules, and imaging probes. Tracers-based nanoparticles are promising candidates, since they combine synergistic advantages for non-invasive, highly sensitive, high-resolution, and quantitative imaging on different modalities. This study represents an overview of current advancements in magnetic materials with clinical potential that will hopefully provide an effective system for diagnosis in the near future. Further exploration is still needed to reveal their potential as promising candidates from simple functionalization of metal oxide nanomaterials up to medical imaging.

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PEGylated Bilirubin-coated Iron Oxide Nanoparticles as a Biosensor for Magnetic Relaxation Switching-based ROS Detection in Whole Blood

Cited by 40 publications

References 36 publications

Advances in sepsis diagnosis and management: a paradigm shift towards nanotechnology

Advances in sepsis diagnosis and management: a paradigm shift towards nanotechnology

Sepsis Management, Controversies, and Advancement in Nanotechnology: A Systematic Review

Imaging Constructs: The Rise of Iron Oxide Nanoparticles

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