PEGylated self-assembled enzyme-responsive nanoparticles for effective targeted therapy against lung tumors

Guo, Fangyuan; Wu, Jiangqing; Wu, Wenchao; Huang, Dongxue; Yan, Qinying; Yang, Qingliang; Gao, Ying

doi:10.1186/s12951-018-0384-8

Cited by 33 publications

(34 citation statements)

References 35 publications

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“…In recent years, the investigation into the concept of viralmimetic, enzyme-responsive NPs has been limited. In most cases, extracellular enzymes such as matrix metalloproteinases (MMPs) (38)(39)(40)(41) or proteases (42) were targeted to unveil active NPs that could then interact with tumor cells. Surprisingly, virus-mimetic ectoenzymatic activation following receptor-mediated endocytosis has never been explored.…”

Section: Discussionmentioning

confidence: 99%

Influenza A virus mimetic nanoparticles trigger selective cell uptake

Figueroa

Veser

Abstiens

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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Poor target cell specificity is currently a major shortcoming of nanoparticles (NPs) used for biomedical applications. It causes significant material loss to off-target sites and poor availability at the intended delivery site. To overcome this limitation, we designed particles that identify cells in a virus-like manner. As a blueprint, we chose a mechanism typical of influenza A virus particles in which ectoenzymatic hemagglutinin activation by target cells is a mandatory prerequisite for binding to a secondary target structure that finally confirms cell identity and allows for uptake of the virus. We developed NPs that probe mesangial cells for the presence of angiotensin-converting enzyme on their surface using angiotensin I (Ang-I) as a proligand. This initial interaction enzymatically transforms Ang-I to a secondary ligand angiotensin II (Ang-II) that has the potential to bind in a second stage to Ang-II type-1 receptor (AT1R). The presence of the receptor confirms the target cell identity and triggers NP uptake via endocytosis. Our virus-mimetic NPs showed outstanding target-cell affinity with picomolar avidities and were able to selectively identify these cells in the presence of 90% off-target cells that carried only the AT1R. Our results demonstrate that the design of virus-mimetic cell interactive NPs is a valuable strategy to enhance NP specificity for therapeutic and diagnostic applications. Our set of primary and secondary targets is particularly suited for the identification of mesangial cells that play a pivotal role in diabetic nephropathy, one of the leading causes of renal failure, for which currently no treatment exists.

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Section: Discussionmentioning

confidence: 99%

Influenza A virus mimetic nanoparticles trigger selective cell uptake

Figueroa

Veser

Abstiens

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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“…Liposomes [139][140][141][142][143][144][145] Quantum dots (QDs) [157] Polymersomes [158] Magnetic nanoparticles [159] Micelles [146][147][148][149][150][151][152][153][154][155][156] [ 160,161] External Light Liposomes [163] MSN [164] Micelles [168] [ 63,[165][166][167]169]…”

Section: Glutathione (Gsh) (4-80 µM) Disulfidementioning

confidence: 99%

DePEGylation strategies to increase cancer nanomedicine efficacy

2019

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“…Besides PEGylation, peptide (ACP)-GPLGIAGQr9-(ACP) was also designed to target matrix metalloproteinases-2 (MMP-2), which is often up-regulated in tumor cells. In this study, Cur-P-NPs with a diameter of 159.7 nm and encapsulation efficiency of 80.12% selectively targeted and penetrated A549 non-small cell lung cancer cells, when compared with that in non-targeted L929 mouse fibroblast cells (Guo et al, 2018 ). Further efforts to improve the accuracy of curcumin delivering have been made by designing polymers whose target or release is environmentally triggered (such as pH, temperature, light, enzymes, and biomolecules).…”

Section: Types Of Nanocurcumin Formulationsmentioning

confidence: 81%

Application of Functional Biocompatible Nanomaterials to Improve Curcumin Bioavailability

Shi

et al. 2020

Front. Chem.

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Curcumin is a lipophilic natural product extracted from turmeric and commonly used as a dietary spice. Being multi-functional, curcumin has been proposed in the prevention and treatment of a broad spectrum of diseases. However, due to unsatisfactory aqueous solubility and hence low bioavailability, clinical application of curcumin has been greatly restrained. To break these limitations, biocompatible nanoformulation, such as liposomes, nanoparticles, micelles, nanoemulsions and conjugates has been employed as alternatives to improve in vivo delivery of curcumin. In this scenario, in order to enhance bioavailability of curcumin, the choice of effective molecules as facilitators is of prominence. In this review, we focus on functional biocompatible materials, including polymers, protein molecules, polysaccharide, surface stabilizers and phospholipid complexes, and decipher their potential applications as how they assist to promote medicinal performance of curcumin.

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PEGylated self-assembled enzyme-responsive nanoparticles for effective targeted therapy against lung tumors

Cited by 33 publications

References 35 publications

Influenza A virus mimetic nanoparticles trigger selective cell uptake

Influenza A virus mimetic nanoparticles trigger selective cell uptake

DePEGylation strategies to increase cancer nanomedicine efficacy

Application of Functional Biocompatible Nanomaterials to Improve Curcumin Bioavailability

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