PEGylation of carbon nanotubes via mussel inspired chemistry: Preparation, characterization and biocompatibility evaluation

Abstract

a b s t r a c tA novel strategy for surface modification of multi-walled carbon nanotubes (MWCNT) was developed via combination of mussel inspired chemistry and Michael addition reaction. In this procedure, pristine MWCNT were first coated with polydopamine (PDA) through self polymerization of dopamine. The PDA functionalized CNT (CNT-PDA) were further functionalized with amino-terminated polymers (polyPEGMA), which were synthesized via free radical polymerization using cysteamine hydrochloride as the chain transfer agent and poly(ethylene glycol) monomethyl ether methacylate as the monomer. The successful modification of CNT was ascertained by a series of characterization techniques including transmission electron microscopy, Fourier transform infrared spectroscopy, thermal gravimetric analysis and X-ray photoelectron spectrometry. The polymer modified CNT showed enhanced dispersibility in aqueous and organic solution. Cytotoxicity evaluation of polymers modified CNT showed that these modified CNT are biocompatible with cells. Finally, due to the universal adhesive of PDA and chain transfer free radical polymerization, this strategy developed in this work can also be extended for surface modification of many other nanomaterials with different functional polymers.

Co-delivery of VP-16 and Bcl-2-targeted antisense on PEG-grafted oMWCNTs for synergistic in vitro anti-cancer effects in non-small and small cell lung cancer

“…Carbon nanostructures have been shown to cause mammalian embryo toxicity and genotoxicity [23], however grafting with biopolymers, such as PEG or polyethyleneimine results in extremely biocompatible hybrid materials [24]. This was shown by our comet assay, demonstrating the genotoxicity comparable to free VP-16 and the exceptional hemocompatibility.…”

Enhanced removal capability of kaolin toward methylene blue by mussel-inspired functionalization

“…Han et al [27] have developed an adhesive and transferable free-standing film with dual function of osteoinductivity and antibacterial activity, which is obtained by sequentially assembling vancomycin immobilized oxidized sodium alginate and dexamethasone encapsulated chitosan-coated BSA nanoparticles on a poly-dopamine layer. Our previous reports also have demonstrated that surface modification of different materials via mussel-inspired chemistry and Michael addition reaction [28][29][30][31][32][33][34][35][36][37][38][39][40][41].…”

A bioinspired strategy for surface modification of silica nanoparticles

“…Dopamine (DA) is a small organic molecule simultaneously contains catechol and amino groups, that has recently been used as a mimic of mussel proteins for surface modification [34][35][36][37][38][39][40][41][42][43][44][45]. It has been demonstrated that DA can be self-polymerized under alkaline solution to form polydopamine (PDA) films, which can be adhered to almost any solid surface without surface pretreatment [46][47][48][49][50][51][52][53][54][55].…”