PEGylation of double-walled carbon nanotubes for increasing their solubility in water

Nie, Hongqi; Guo, Wei; Yuan, Yuan; Zhang, Dou; Shi, Zujin; Liu, Zhen; Wang, Haifang; Liu, Yuanfang

doi:10.1007/s12274-010-1014-4

Cited by 27 publications

(26 citation statements)

References 16 publications

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“…TGA analysis shows that the pegylated sample is stable up to 350°C and an abrupt weight loss occurred from 350°C to 400°C; these values match the temperature range for polyethyleneglycol chains decomposition [44]; thus, a weight loss of 13% can represent the measure of polymer grafted on CNT. The antiretroviral agent CHI360 was then anchored to the tubes after reaction with the bidentate reagent succinic anhydride in the presence of triethylamine.…”

Section: 6mentioning

confidence: 62%

Synthesis and anti-HIV activity of carboxylated and drug-conjugated multi-walled carbon nanotubes

Iannazzo

Pistone

Galvagno

et al. 2015

Carbon

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Section: 6mentioning

confidence: 62%

Synthesis and anti-HIV activity of carboxylated and drug-conjugated multi-walled carbon nanotubes

Iannazzo

Pistone

Galvagno

et al. 2015

Carbon

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“…13,55 PEGylation is a useful method to improve the dispersibility of nanomaterials and cloak them from the MPS due to its high water solubility and biocompatibility. 32,33,37,38,56 The polyPEGylation methodology in the current report disclosed the enhanced stability of nanomaterials by synthetic polymer, represents a general method for nanomaterial modification.…”

mentioning

confidence: 84%

PolyPEGylated nanodiamond for intracellular delivery of a chemotherapeutic drug

et al. 2012

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Water dispersible and biocompatible polyPEGylated ND nanoparticles were prepared via surface-initiated atom transfer radical polymerization. Cell internalization study reveals that ND nanoparticles facilitate the transport of doxorubicin hydrochloride into A549 cells, indicating their potential applications in cancer therapy.Over the past few decades, carbon nanomaterials (CNMs) have attracted a great deal of scientific and technological attention due to their unique structure and remarkable electronic, mechanical and thermal properties. These materials have shown promising applications in different fields such as electronics, energy conversion and storage, and biomedicine etc. 1-6 Nanodiamond (ND) is a relative new class of CNM, which has been investigated extensively for biomedical applications in recent years due to its excellent physicochemical properties, biocompatibility, inexpensive large scale synthesis and small size (2-10 nm). 7-18 It has been reported that fluorescent ND nanoparticles could be used as bioprobes for single particle tracing in cells and even in small organisms such as Caenorhabditis elegans. [19][20][21] It has also been suggested that ND might be useful for controlled drug delivery and gene therapy as well as tissue engineering. 22-26 For many of these biomedical applications, effective dispersion of ND in aqueous solution especially in physiological solution is necessary. On the other hand, like many other nanomaterials, ND nanoparticles are readily recognized as foreigners by the mononuclear phagocytic system (MPS) of cells and are rapidly cleared from blood circulation after intravenous administration, resulting in cumulative negative effects on the MPS and leading to impairment of this vital host defence system. 27-31 Therefore, effective dispersion of ND in aqueous media and preventing it from recognition by the MPS are crucial for the practical biomedical applications of ND.Polyethylene glycol (PEG) is a class of hydrophilic polymer with outstanding physicochemical and biological properties, such as excellent water-solubility and biocompatibility. 32,33 The conjugation of PEG chains on the nanoparticle surface (PEGylation) is expected to render nanoparticle dispersion as well as reduce protein opsonization and subsequent phagocytosis by MPS to the nanoparticles, which can help these PEGylated nanoparticles escape from the reticuloendothelial system (RES) after intravenous administration. To date, PEGylation of many nanoparticles, such as liposome, quantum dots, gold nanoparticles, carbon nanotubes and other nanomaterials could extremely reduce the nanoparticles' uptake by MPS and prolong their blood circulation time. [34][35][36][37][38] Our previous study has demonstrated that PEG or polyPEGMA molecules could be immobilized onto the surface of ND via both ''grafting to'' and ''grafting from'' methods. 39 The polyPEGMA conjugated ND showed enhanced dispersibility in both aqueous and organic media.In current work, we present the polyPEGylation of ND through surface-initiated atom t...

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“…Oxidation is often used in CNT chemistry to generate reactive groups including carboxyl and hydroxyl groups on nanotube surface [23]. Further engineering of oxidized CNT surface could introduce other functionalities or improve its biocompatibility, e.g., by coating with hydrophilic polymers such as polyethylene glycol, PEG [24]. Besides oxidization, many other types of surface chemistry exist to covalently functionalize CNTs.…”

Section: Surface Chemistry Of Carbon Nanotubesmentioning

confidence: 99%

Carbon nanotubes for in vivo cancer nanotechnology

Zhang¹,

Yang²,

Liu³

2010

Sci. China Chem.

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The latest progress of using carbon nanotubes (CNTs) for in vivo cancer nanotechnology is reviewed. CNTs can be functionalized by either covalent or non-covalent chemistry to produce functional bioconjugates for many in vivo applications. In vivo behaviors and toxicology studies of CNTs are summarized, suggesting no significant toxicity of well functionalized CNTs to the treated mice. Owing to their unique chemical and physical properties, CNTs, especially single-walled carbon nanotubes (SWNTs), have been widely used for various modalities of in vivo cancer treatment and imaging. Future development of CNT-based nanomedicine may bring novel opportunities to cancer diagnosis and therapy. carbon nanotubes, in vivo behaviors, cancer therapy, cancer imaging

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PEGylation of double-walled carbon nanotubes for increasing their solubility in water

Cited by 27 publications

References 16 publications

Synthesis and anti-HIV activity of carboxylated and drug-conjugated multi-walled carbon nanotubes

Synthesis and anti-HIV activity of carboxylated and drug-conjugated multi-walled carbon nanotubes

PolyPEGylated nanodiamond for intracellular delivery of a chemotherapeutic drug

Carbon nanotubes for in vivo cancer nanotechnology

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