Pelargonidin 3-glucoside-enriched strawberry attenuates symptoms of DSS-induced inflammatory bowel disease and diet-induced metabolic syndrome in rats

Ghattamaneni, Naga K.R.; Sharma, Ashwini; Panchal, Sunil K.; Brown, Lindsay

doi:10.1007/s00394-019-02130-1

Cited by 30 publications

(11 citation statements)

References 62 publications

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“…Pelargonidin-3,5-glucoside is also found in red petals of Korean edible rose ( Rosa hybrida ) but its content is lower (31.2 ± 1.4/100 g). A more common constituent is pelargonidin-3-glucoside, which is present in strawberry fruit and is probably responsible for its anti-inflammatory effect [ 18 , 19 ]. This monoglucoside is also found in pomegranate flowers, but the amount is much smaller, and determination was not the aim of this study.…”

Section: Resultsmentioning

confidence: 99%

Pomegranate Flower Extract—The Health-Promoting Properties Optimized by Application of the Box–Behnken Design

et al. 2022

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Herbal raw materials with antidiabetic activity can be a valuable support to therapy. An optimized extraction process allows for the best possible health-promoting effect. Box–Behnken design was employed to optimize the content of methanol used in the extraction mixture, its time, and temperature. The aim of this study was to enhance the efficiency of the pomegranate flowers extraction process in order to obtain extracts with the highest enzyme inhibition power (α-amylase and α-glucosidase), which is important for the antidiabetic effect and the highest antioxidant activity (DPPH assay). In the Box–Behnken design model, the content of pelargonidin-3,5-glucoside–anthocyanin compound that is associated with antidiabetic activity was also optimized as a variable associated with the action profile of pomegranate flower extracts. The process optimization carried out in this study provides a basis for further research using the pomegranate flower extract with the most potent desired properties, essential for supporting diabetes treatment based on pomegranate flowers.

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Section: Resultsmentioning

confidence: 99%

Pomegranate Flower Extract—The Health-Promoting Properties Optimized by Application of the Box–Behnken Design

et al. 2022

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“…d -Mannitol assay was used to evaluate intestinal permeability. 23 After fasting for 6 h, the mice were orally administered with d -mannitol (0.6 g kg −1 ). Then, fasting and water prohibition were continued for 6 h, and then blood was collected from the heart, which was centrifuged (2500 g at 4 °C for 20 min) to obtain serum for d -mannitol analysis.…”

Section: Methodsmentioning

confidence: 99%

Multi-omics reveals that green pea (Pisum sativum L.) hull supplementation ameliorates non-alcoholic fatty liver disease via the SHMT2/glycine/mTOR/PPAR-γ signaling pathway

et al. 2023

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“…Findings revealed that P3G treatment attenuated DSS-induced IBD symptoms. Likewise, P3G treatment in rats fed a high-carbohydrate, HFD resulted in attenuation of metabolic syndrome (reduced systolic blood pressure, ventricular stiffness, cardiac and liver structure, abdominal fat, and body weight gain) ( 233 ), suggesting that anthocyanidins, specifically pelargonidins, target AhR, decreasing inflammation to attenuate symptoms of IBD and metabolic functions in metabolic syndrome. These findings are relevant considering that diets containing a high content of phytochemicals are generally rich in fruit and vegetables, which are typically lacking in a Western diet.…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

Regulation of Intestinal Inflammation by Dietary Fats

et al. 2021

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With the epidemic of human obesity, dietary fats have increasingly become a focal point of biomedical research. Epidemiological studies indicate that high-fat diets (HFDs), especially those rich in long-chain saturated fatty acids (e.g., Western Diet, National Health Examination survey; NHANES ‘What We Eat in America’ report) have multi-organ pro-inflammatory effects. Experimental studies have confirmed some of these disease associations, and have begun to elaborate mechanisms of disease induction. However, many of the observed effects from epidemiological studies appear to be an over-simplification of the mechanistic complexity that depends on dynamic interactions between the host, the particular fatty acid, and the rather personalized genetics and variability of the gut microbiota. Of interest, experimental studies have shown that certain saturated fats (e.g., lauric and myristic fatty acid-rich coconut oil) could exert the opposite effect; that is, desirable anti-inflammatory and protective mechanisms promoting gut health by unanticipated pathways. Owing to the experimental advantages of laboratory animals for the study of mechanisms under well-controlled dietary settings, we focus this review on the current understanding of how dietary fatty acids impact intestinal biology. We center this discussion on studies from mice and rats, with validation in cell culture systems or human studies. We provide a scoping overview of the most studied diseases mechanisms associated with the induction or prevention of Inflammatory Bowel Disease in rodent models relevant to Crohn’s Disease and Ulcerative Colitis after feeding either high-fat diet (HFD) or feed containing specific fatty acid or other target dietary molecule. Finally, we provide a general outlook on areas that have been largely or scarcely studied, and assess the effects of HFDs on acute and chronic forms of intestinal inflammation.

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Pelargonidin 3-glucoside-enriched strawberry attenuates symptoms of DSS-induced inflammatory bowel disease and diet-induced metabolic syndrome in rats

Cited by 30 publications

References 62 publications

Pomegranate Flower Extract—The Health-Promoting Properties Optimized by Application of the Box–Behnken Design

Pomegranate Flower Extract—The Health-Promoting Properties Optimized by Application of the Box–Behnken Design

Multi-omics reveals that green pea (Pisum sativum L.) hull supplementation ameliorates non-alcoholic fatty liver disease via the SHMT2/glycine/mTOR/PPAR-γ signaling pathway

Regulation of Intestinal Inflammation by Dietary Fats

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