Pelvic and aortic lymph node metastasis in epithelial ovarian cancer

Pereira, Augusto; Magrina, Javier F.; Rey, Victoria E.; Cortes, Manuel; Magtibay, Paul M.

doi:10.1016/j.ygyno.2007.01.028

Cited by 77 publications

(39 citation statements)

References 16 publications

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“…Among these lymph nodes, particularly in pT1 patients, the PANsup was the most frequently involved in metastasis, followed by the PANinf, the internal iliac, and the obturator nodes. The third lymphatic route, which flows toward the external iliac and the inguinal chain along the round ligament, is called the tertiary, accessory disseminating pathway [15,16]. The lymph node groups on this route were not involved in pT1 patients, supporting the aforementioned metastatic pathway of ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

Incidence of metastasis in the circumflex iliac nodes distal to the external iliac nodes in ovarian cancer

Ohba

Todo

Akashi

et al. 2012

Gynecologic Oncology

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Section: Discussionmentioning

confidence: 99%

Incidence of metastasis in the circumflex iliac nodes distal to the external iliac nodes in ovarian cancer

Ohba

Todo

Akashi

et al. 2012

Gynecologic Oncology

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“…Metastasis to the para-aortic lymph nodes is the primary route of lymphatic dissemination in ovarian cancer, and the high para-aortic lymph node above the inferior mesenteric artery (IMA) is a frequently involved site [12][13][14][15][16]. Despite this, lymphadenectomy has not been performed in practice as a part of the routine staging procedure.…”

Section: Original Articlementioning

confidence: 99%

Should be para-aortic lymphadenectomy up to the level of the renal vein mandatory in ovarian cancer patients presenting ovarian cancer presumed to be confined to the ovary?

Chang

Bristow

Kong

et al. 2012

Gynecologic Oncology

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Should be para-aortic lymphadenectomy up to the level of the renal vein mandatory in ovarian cancer patients presenting ovarian cancer presumed to be confined to the ovary? www.ejgo.orgObjective: The aim of this study was to evaluate the impact of para-aortic lymphadenectomy up to the renal vessels on the accurate staging in ovarian cancer patients presumed preoperatively to be confined to the ovary. Methods: We retrospectively analyzed data on 124 patients with primary epithelial ovarian cancer who were preoperatively thought to have tumor confined to the ovary and underwent primary staging surgery. The distribution of lymph node metastasis and various risk factors for nodal involvement were investigated. Results: Surgical staging yielded: 87 (70.2%) patients had International Federation of Gynecology and Obstetrics (FIGO) stage I disease and 37 (29.8%) patients had stage II-III disease: 4 IIA, 6 IIB, 9 IIC, 1 IIIA, and 17 IIIC. Eighty-six patients had pelvic lymphadenectomy only and 69 had pelvic and para-aortic lymphadenectomy. Lymph node metastases were found in 17 (24.6%) of 69 patients; 5 (7.2%) patients had lymph node metastasis in the pelvic lymph nodes only, 8 (11.6%) in the para-aortic lymph nodes only, and 4 (5.8%) in both pelvic and para-aortic lymph nodes. Six (8.7%) patients had lymph node metastasis in the paraaortic lymph node above the level of the inferior mesenteric artery. On multivariate analysis, grade 3 tumor (p=0.01) and positive cytology (p=0.03) were independent predictors for lymph node metastasis. Conclusion: A substantial number of patients with apparently early ovarian cancer had upstaged disease. Of patients who underwent lymphadenectomy, some patients had lymph node metastasis above the level of the inferior mesenteric artery. Paraaortic lymphadenectomy up to the renal vessels may detect occult metastasis and be of help in tailoring appropriate adjuvant treatment as well as giving useful information about the prognosis.

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“…Lymphogenous metastasis is an indicator of disease aggressiveness, recurrence and prognosis (3,4). Kleppe et al (5) reported a 14.2% incidence of lymphatic metastases in stage I-II epithelial OC, predominantly in the para-aortic and pelvic regions.…”

Section: Introductionmentioning

confidence: 99%

Identification of lymphatic metastasis-associated genes in a metastatic ovarian cancer cell line

Kang

Cai³

et al. 2015

Molecular Medicine Reports

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Abstract. Ovarian cancer (OC) is the gynecological malignancy with the highest rate of mortality, and lymphatic metastasis is a critical factor in disease recurrence and prognosis. In the current study, the SKOV-3/LN403 cell line, which has high potential for lymph node metastasis was established as a result of four rounds of selection from retroperitoneal lymph nodes following intraperitoneal injections of SKOV-3 ovarian adenocarcinoma cells. In comparison to the parental SKOV-3 cell line, SKOV-3/LN403 has a higher rate of proliferation, is more invasive and exhibits greater resistance to paclitaxel. Subsequently, a novel animal model of OC lymphatic metastasis was developed with SKOV-3/LN403 cells and a high incidence of positive metastatic lymph nodes, peritoneal dissemination and bloody ascites were observed, which mimicked the clinical outcome of patients with OC. Analysis of the gene expression profiles of SKOV-3 and SKOV-3/LN403 cells identified several genes and pathways that may be involved in lymphatic metastasis of OC. The induction of focal adhesion kinase expression provides a potential therapeutic target for OC lymphatic metastasis.

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Pelvic and aortic lymph node metastasis in epithelial ovarian cancer

Cited by 77 publications

References 16 publications

Incidence of metastasis in the circumflex iliac nodes distal to the external iliac nodes in ovarian cancer

Incidence of metastasis in the circumflex iliac nodes distal to the external iliac nodes in ovarian cancer

Should be para-aortic lymphadenectomy up to the level of the renal vein mandatory in ovarian cancer patients presenting ovarian cancer presumed to be confined to the ovary?

Identification of lymphatic metastasis-associated genes in a metastatic ovarian cancer cell line

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