2020
DOI: 10.1111/bju.15088
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Pelvic exenteration surgery in patients with locally advanced castration‐naïve and castration‐resistant, symptomatic prostate cancer

Abstract: Objectives To evaluate retrospectively the surgical, symptomatic and oncological outcomes of pelvic exenteration surgery (PES) in men with significant intrapelvic complications of locally advanced castration‐sensitive (CSPC) and castration‐resistant prostate cancer (CRPC). Patients and Methods A total of 103 patients with locally advanced progressive and symptomatic CSPC or CRPC underwent PES (radical cystoprostatectomy, n = 71 [68.9%]; radical prostatectomy with continent vesicostomy, n = 9 [8.7%]; total exen… Show more

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Cited by 10 publications
(14 citation statements)
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References 26 publications
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“…Preoeprative fitness is also a significant determinant of OS as shown by Maisch et al In their retrospective series of 76 locally advanced BCa patients, ASA scores of The role of surgery for loco-regional and advanced urological cancers 1-2 and a haemoglobin value at least 11.7 g/dl correlated significantly with prolonged OS. Heidenreich et al [43] ], CD grade at least 3 complication rates ranged from 12 to 31%, which is comparable to that observed in large series for curative radical cystectomy [46]. Median symptom-free survival was 16.0 and 27.9 months in a PCa and BCa series, respectively.…”
Section: Pelvic Exenterationsupporting
confidence: 60%
“…Preoeprative fitness is also a significant determinant of OS as shown by Maisch et al In their retrospective series of 76 locally advanced BCa patients, ASA scores of The role of surgery for loco-regional and advanced urological cancers 1-2 and a haemoglobin value at least 11.7 g/dl correlated significantly with prolonged OS. Heidenreich et al [43] ], CD grade at least 3 complication rates ranged from 12 to 31%, which is comparable to that observed in large series for curative radical cystectomy [46]. Median symptom-free survival was 16.0 and 27.9 months in a PCa and BCa series, respectively.…”
Section: Pelvic Exenterationsupporting
confidence: 60%
“…In our review, pelvic exenteration for prostate cancer has been described in different settings based on different indications. The majority of retrospective studies reporting the indications, complications, and outcomes of pelvic exenteration for prostate cancer are summarized in Table 1 [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42]. Table 2 [43][44][45][46][47][48] summarizes the reported cases of minimally invasive pelvic exenteration for prostate cancer, whether laparoscopic or robot-assisted.…”
Section: Abbreviationsmentioning
confidence: 99%
“…As described earlier, invasion of the bladder or rectum may necessitate anterior or total pelvic exenteration even in patients with CRPC; however, patients should be good surgical candidates with an expected survival of over 1 year [52,53]. Recently, Heidenreich et al reviewed 103 patients with LAPca, of whom 84 had castrate-resistant prostate cancer and underwent pelvic exenteration for symptom relief [37]. Overall, 78.6% of patients were able to obtain complete relief of symptoms in their remaining lifetime.…”
Section: Role Of Exenteration In Castrate-resistant Prostate Cancermentioning
confidence: 99%
“…In highly selected patients, pelvic exenteration is an option. Surgery can be performed in a well tolerated manner, although complications are increased compared with the aforementioned surgical approaches [29 ▪▪ ,30]. The indication for surgery is not tumour progression but any kind of symptoms.…”
Section: Palliative Surgeriesmentioning
confidence: 99%