The study aimed to obtain the best doses of vermicompost and NPK Mutiara fertilizer to develop, produce, and quality tomato (Solanum lycopersicum L) plants. The factorial study was conducted in a completely randomized design with three replications. The first factor was the dose of vermicompost fertilizer in three levels: 100, 200, and 300 grams/plant. The second factor was the dose of NPK Mutiara 16:16:16, arranged in three levels: 10, 20, and 30 grams/plant. The results showed that the interaction was significantly different in the observation of plant height and number of leaves for the largest average in the K2N2 treatment, namely 62.23 cm for plant height and 26 for the number of leaves. In the study of fruit number, fruit weight, and production per hectare, there was no interaction at all in each treatment. This research concluded that there were significantly different interactions for the parameters of plant height and the number of leaves. However, there were no significant interactions by parameters of fruit number, fruit weight, and production per hectare. It is recommended to conduct a restudy to get the correct dose of both vermicompost and fertilizer for tomato plants. Penelitian bertujuan untuk mendapatkan takaran dosis pupuk kascing dan pupuk NPK Mutiara terbaik untuk perkembangan, produksi dan kualitas tanaman tomat (Solanum lycopersicum L). Penelitian factorial dilakukan dalam Rancangan Acak Lengkap dalam tiga ulangan. Faktor pertama adalah takaran pupuk kascing tersusun tiga taraf: 100, 200, dan 300 gram/tanaman. Faktor kedua adalah takaran pupuk NPK Mutiara 16:16:16 tersusun tiga taraf: 10, 20, dan 30 gram/tanaman. Hasil penelitian mendapatkan interaksi berbeda nyata di pengamatan tinggi tanaman dan jumlah daun untuk rata-rata terbesar di perlakuan K2N2, yaitu 62,23 cm untuk tinggi tanaman dan 26 untuk jumlah daun. Pada penelitian jumlah buah, berat buah, dan produksi per hektar tidak ada interaksi pada setiap perlakuan. Dalam peneletian ini disimpulkan terdapat interaksi yang berbeda nyata untuk parameter tinggi tanaman dan jumlah daun, namun tidak terdapat interaksi berbeda nyata oleh parameter jumlah buah, berat buah, dan produksi per hektar. Disarankan untuk diadakan penelitian ulang guna mendapatkan dosis yang benar untuk tanaman tomat.