Pemphigus induction by influenza vaccination

Mignogna,; Muzio, Lorenzo Lo; Ruocco, Eleonora

doi:10.1046/j.1365-4362.2000.00051-5.x

Cited by 45 publications

(26 citation statements)

References 4 publications

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“…On the other hand, there are numerous reports of various skin diseases that developed after influenza vaccine injection [1,2,3,4,5,6,7,8,9,10]; they include TEN, Sweet’s disease, erythema nodosum, Gianotti-Crosti syndrome, vasculitis, bullous pemphigoid, pemphigus and LP (fig. 3): the period of increased risk of developing these adverse events was different depending on the immune responses induced by influenza vaccination.…”

Section: Discussionmentioning

confidence: 99%

“…An influenza vaccine often causes local reactions, such as induration and erythema at the injection site, and occasionally systemic reactions; the latter reactions include toxic epidermal necrolysis (TEN), bullous pemphigoid, lichen planus (LP) and so on [1,2,3,4,5,6,7,8,9,10]. The association between these reactions and the influenza vaccine, however, has not been widely recognized.…”

Section: Introductionmentioning

confidence: 99%

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Lichen Planus Occurring after Influenza Vaccination: Report of Three Cases and Review of the Literature

Sato

Kano²,

Shiohara³

2010

Dermatology

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Although influenza vaccine is thought to be effective and safe, it occasionally causes systemic reactions such as toxic epidermal necrolysis, bullous pemphigoid, lichen planus (LP), etc. The period of increased risk of developing these events was different depending on the immune responses induced by the vaccination. We report 3 cases of LP which appeared after an influenza vaccination. Our cases indicate that the period of increased risk of developing vaccine-related LP was concentrated within 2 weeks after vaccination, and that the vaccine alone represents a triggering factor necessary for immune alteration sufficient for the development of LP. Because these adverse events tend to develop over a predictable time course, the time of onset may give an important clue to the diagnosis of vaccine-related diseases. We suggest that a history of recent vaccination should be sought in all patients presenting with linear LP.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lichen Planus Occurring after Influenza Vaccination: Report of Three Cases and Review of the Literature

Sato

Kano²,

Shiohara³

2010

Dermatology

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“…In the literature there are 19 papers reporting 37 patients experiencing skin adverse effects after an influenza vaccination [4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22]. There are only 2 reports of a typical drug reaction after an influenza vaccination: a case of generalized bullous fixed drug eruption and a case of toxic epidermal necrolysis [6,13].…”

Section: Discussionmentioning

confidence: 99%

“…There are only 2 reports of a typical drug reaction after an influenza vaccination: a case of generalized bullous fixed drug eruption and a case of toxic epidermal necrolysis [6,13]. Other papers report neutrophilic dermatosis, bullous pemphigoid, pemphigus, vasculitis, Gianotti-Crosti syndrome, dermatomyositis and lichen planus (table 1) [4,5,7,8,9,10,11,12,14,15,16,17,18,19,20,21,22]. Tsushima et al [14] reported a case of an erythema-nodosum-like eruption appearing 7 days after an influenza vaccination.…”

Section: Discussionmentioning

confidence: 99%

“…Cutaneous adverse effects consisting mainly of a local reaction with erythema, induration and pain at the vaccination site are rarely reported [4,5]. Rare cases of systemic reactions with cutaneous manifestations such as vasculitis or neutrophilic dermatosis have been observed [5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22]. We describe the first case of CHP after H1N1 vaccination in a child and discuss the spectrum of cutaneous reactions to influenza vaccine.…”

Section: Introductionmentioning

confidence: 99%

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Cytophagic Histiocytic Panniculitis after H1N1 Vaccination: A Case Report and Review of the Cutaneous Side Effects of Influenza Vaccines

et al. 2011

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Cytophagic histiocytic panniculitis (CHP) is a rare disease mostly caused by viral infections and/or lymphoproliferative diseases. We describe a case of CHP associated with H1N1 vaccine during the winter 2009–2010 vaccination campaign and discuss the cutaneous side effects of influenza vaccines. A 6-year-old child presented with inflammatory subcutaneous nodules, which had appeared 1 month after the first injection of H1N1 vaccine and 1 week after the second injection. There was no history of recent infection. The skin lesions spontaneously disappeared without scarring. In CHP the abnormal cytokine secretion from neoplastic or reactive T cells promotes monocyte-macrophage activation and haemophagocytosis. Vaccination is not a common cause of CHP, but it seems possible that, as in infectious diseases, reactive T cells to the vaccine antigen could trigger CHP.

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