Pemphigus vulgaris – A report of three cases and review of literature

Banerjee, Ishita; Bhowmik, Biyas; Maji, Anirban; Sinha, Rupam

doi:10.4103/jfmpc.jfmpc_133_18

Cited by 11 publications

(12 citation statements)

References 12 publications

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“…Pemphigus vulgaris exhibits positive "Nikolsky's sign" which is the ability to induce peripheral extension of a blister and/or exfoliation of epithelium as a consequence of applying tangential pressure with an index finger or thumb to the affected skin, peri lesional skin, or normal skin. 3,7 Nikolsky's sign was positive in the present case which gave a clue to the diagnosis of the disease.…”

Section: Discussionsupporting

confidence: 61%

“…1 The global prevalence of pemphigus vulgaris is approximately 0.1 to 0.5% per million population per year with higher prevalence in certain ethnic groups, such as Ashkenazi Jews, Japanese, and populations from the Mediterranean ancestry. 2,3 The disease is mediated by circulating immunoglobulin G (IgG) autoantibodies against the desmosomal cadherin, desmoglein 1 and 3. Desmoglein 1(dsg-1) is mostly seen within the epithelium of skin, while desmoglein 3(dsg-3) is commonly seen in mucosal epithelium.…”

Section: Introductionmentioning

confidence: 99%

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Oral Pemphigus Vulgaris: A Case Report

Baral¹,

Ojha²,

Bajracharya³

2020

JCMC

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Pemphigus vulgaris is an autoimmune blistering disease clinically presenting as vesicles, bullae and erosion on the skin and mucous membrane. Histopathologically, it is characterized by acantholysis and supra basilar split. The underlying mechanism causing intra epithelial split in pemphigus vulgaris is binding of IgG autoantibodies to desmoglin 3 which belongs to a transmembrane glycoprotein adhesion molecule. Here we present a case of 27 years old male patient suffering from pemphigus vulgaris. This Case report highlights the importance of detailed case history, thorough clinical examination and appropriate investigation to reach a diagnosis of vesiculobullous lesion.

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Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Oral Pemphigus Vulgaris: A Case Report

Baral¹,

Ojha²,

Bajracharya³

2020

JCMC

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“…Treatment with rituximab, an anti-CD20 antibody, is shown to be effective in many cases (12). Pulse therapy for pemphigus such as IV dexamethasone and cyclophosphamide pulse, has been successful in the recalcitrant cases (3).…”

Section: Discussionmentioning

confidence: 99%

“…The word 'pemphigus' has originated from a Greek word called pemphix meaning bubble or a blister and the word 'vulgaris' has originated from a Latin word called vulgaris meaning common (2). The overall prevalence rate of this disease is 0.1 to 0.5% per one million population in a year with a much greater prevalence in the ethnic groups like Ashkenazi Jews, Japanese, and Mediterranean ancestry (3). The pathology involves formation of circulating immunoglobulin G autoantibodies against the desmosomal adhesion molecules namely cadherins and desmoglein 1 and 3 present in the epithelium.…”

Section: Introductionmentioning

confidence: 99%

Role of oral physician in the management of pemphigus vulgaris- A geriatric case report

Kannan¹,

Deivanayagi²,

Preethy³

2023

Biomedicine

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Pemphigus is a blister forming disease of both mucosa and skin of autoimmune origin. Most commonly seen in old age individuals and oral lesions precede the skin lesions in most cases. This is a report of a unique case of pemphigus vulgaris in an elderly male patient where oral lesions started initially followed by skin lesions. It was provisionally diagnosed by our oral medicine specialists on the very first visit and confirmed after a biopsy. The patient was treated successfully with systemic steroids and azathioprine with reduction in dose after 3 weeks. The healing was satisfactory and the patient is under follow-up.

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“…[4] Vital to patient management is an early diagnosis, when lower doses rendered for shorter periods can effectively control the disease. [6] In general, pemphigus vulgaris is managed with topical and systemic steroids. Guidelines set by the British Association of Dermatologists recommended treatment of Pemphigus Vulgaris in two phases: Induction phase to control the disease and maintenance phase for consolidation and treatment tapering.…”

Section: Discussionmentioning

confidence: 99%

Oral pemphigus vulgaris: A case report and review of the literature

Rishi

Chawla

Dubey

2022

AUJMSR

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The oral cavity presents with a variety of pathological lesions ranging from benign to malignant. Autoimmune mucocutaneous disorders of the oral cavity constitute an important group of lesions that pose diagnostic, therapeutic, and prognostic difficulties to the dental clinician. Many of the lesions may become potentially fatal if they are undiagnosed or misdiagnosed in their early stages. Pemphigus vulgaris is a potentially life-threatening autoimmune mucocutaneous disorder that causes blisters and erosions of the skin and the mucous membrane. It manifests clinically as vesicles, bullae, or desquamative gingivitis and histopathologically shows the presence of acantholysis. Eighty to ninety percent of patients with pemphigus vulgaris develop oral lesions and in 60% of cases, oral lesions are the first sign. Timely recognition and therapy of oral lesions are critical as they may prevent skin involvement. The incidence of pemphigus vulgaris occurs in a ratio of 2:1 (female: male). Adequate knowledge of diagnostic and therapeutic modalities helps the clinician in appropriate management. In this article, we report a case of oral pemphigus vulgaris in a 34-year-old male.

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Pemphigus vulgaris – A report of three cases and review of literature

Cited by 11 publications

References 12 publications

Oral Pemphigus Vulgaris: A Case Report

Oral Pemphigus Vulgaris: A Case Report

Role of oral physician in the management of pemphigus vulgaris- A geriatric case report

Oral pemphigus vulgaris: A case report and review of the literature

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