Pemphigus vulgaris: benefits of tetracycline as adjuvant therapy in a series of thirteen patients

Calebotta, Adriana; Sáenz, Ana María; González, Francisco; Carvalho, Marisol; Castillo, Rafael

doi:10.1046/j.1365-4362.1999.00624.x

Cited by 49 publications

(21 citation statements)

References 38 publications

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“…51,52 The first report of high-dose IVIg use in the treatment of PV revealed no clinical change in 2 patients and progression of disease in a third patient after one cycle of IVIg. 53 Recently, Engineer et al reviewed 8 reports that analyzed the use of IVIg in PV and observed efficacy in 17 of the 18 patients described.…”

Section: Management Of Pemphigus Vulgarismentioning

confidence: 99%

Management of autoimmune bullous diseases: Pharmacology and therapeutics

Mutasim

2004

Journal of the American Academy of Dermatology

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Section: Management Of Pemphigus Vulgarismentioning

confidence: 99%

Management of autoimmune bullous diseases: Pharmacology and therapeutics

Mutasim

2004

Journal of the American Academy of Dermatology

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“…18,19,[23][24][25][26] In PV and BP, most authors 16,18,19,[23][24][25][26] report efficacy at least equal to that of previous immunosuppressive therapies, and some suggest use of tetracyclines as a first-line agent in light of their favorable side effect profile. Although most studies focus on the efficacy and adverse effects of tetracycline therapy, minocycline has been used often as an initial agent 16 or as an alternative if tetracycline adverse effects develop.…”

Section: Commentmentioning

confidence: 99%

Minocycline-Induced Hyperpigmentation in Patients With Pemphigus and Pemphigoid

Ozog

Gogstetter²,

Scott³

et al. 2000

Arch Dermatol

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“…Minocycline is a broad-spectrum tetracycline antibiotic that is reportedly effective in autoimmune bullous diseases such as bullous pemphigoid (6) and pemphigus (7). In the present case, minocycline was effective for treating the patient, and prednisolone dose could gradually be reduced.…”

Section: Discussionmentioning

confidence: 62%

Inflammatory Epidermolysis Bullosa Acquisita Effectively Treated with Minocycline

Kawase

Oshitani²,

Mizutani³

et al. 2014

Acta Derm Venerol

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Epidermolysis bullosa acquisita (EBA) is an autoimmune mechanobullous disease that is clinically characterised by blisters and erosions on the skin and mucous membranes (1). Patients with EBA exhibit autoantibodies to type VII collagen (2) and are usually treated with corticosteroids, immunosuppressive agents, colchicine, diaphenylsulfone (DDS), or intravenous immunoglobulin (IVIG); however, to our knowledge, minocycline has not been reported to be effective in such cases. In the present report, we describe a patient with EBA who was initially treated with corticosteroids, and then successfully treated with minocycline for recurrence of EBA following corticosteroid dose reduction. The histological examination of the skin eruptions indicated subepidermal bulla formation as well as infiltration of lymphocytes, eosinophils and neutrophils in the upper dermis. As minocycline is known to inhibit neutrophil and eosinophil recruitment as well as cytokine production, it may be considered as a therapeutic option for EBA, particularly in cases exhibiting infiltration within the skin lesion on histological examination. CASE REPORTA 71-year-old Japanese woman, weighing 44 kg, presented with a 1-month history of many bullae with slight itch on the skin over her entire body (Fig. 1a) and on the tongue (Fig. 1b) and oral mucosa. She had no history of allergy, and the laboratory data were within the normal ranges, including the leucocyte count (6,390/μl; normal range: 3,000-7,900/μl), eosinophil count (198/ μl; normal 100-500/μl) and IgG concetration (1,188 mg/dL; normal 890-1,850 mg/dL). Antinuclear antibodies were negative. Histological examination indicated subepidermal bulla formation along with infiltration of lym phocytes, eosinophils, and a small amount of neutrophils in the upper dermis ( Fig. 1c and d).Direct immunofluorescence (IF) examination of a biopsy specimen from erythema indicated the deposition of immunoglobulin (Ig) G and C3 at the basement membrane zone with u-serrated pattern (3). Indirect IF using 1 M NaCl-split normal human skin sections showed IgG anti-basement membrane zone antibodies, which reacted with the dermal side. Using an enzyme-linked immunosorbent assay (ELISA: MBL, Nagoya, Japan), the titres of IgG antibody to type VII collagen were 76.7 and 146.6, at the first consultation and 2 weeks after the first consultation, respectively (Fig. 2). Antibodies to desmo glein 1 and 3, bullous pemphigoid (BP) 180, and BP 230 were not detected in the patient's serum by ELISA. Based on the clinical features, histopathological findings, IgG deposition at the basement membrane zone, and presence of IgG antibodies to type VII collagen in serum, we diagnosed the patient with EBA. Although the patient was then treated with prednisolone (45 mg/day), the new development of bullae was still noted. The addition of cyclosporine (150 mg/day) to the regimen inhibited the formation of new bullae, and the prednisolone dose could be gradually reduced. However, during this dose reduction period, when the patient was being tr...

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Pemphigus vulgaris: benefits of tetracycline as adjuvant therapy in a series of thirteen patients

Abstract: Tetracycline was shown to be effective as an adjuvant therapy for pemphigus with low toxicity and safety.

Cited by 49 publications

References 38 publications

Management of autoimmune bullous diseases: Pharmacology and therapeutics

Management of autoimmune bullous diseases: Pharmacology and therapeutics

Minocycline-Induced Hyperpigmentation in Patients With Pemphigus and Pemphigoid

Inflammatory Epidermolysis Bullosa Acquisita Effectively Treated with Minocycline

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