Penetration and effectiveness of prophylactic fluoroquinolones in experimental methicillin-sensitive or methicillin-resistant Staphylococcus aureus anterior chamber infections

Balzli, Charles L.; Caballero, Armando R.; Tang, Aihua; Weeks, Anastasia C.; O’Callaghan, Richard J.

doi:10.1016/j.jcrs.2010.06.070

Cited by 9 publications

(5 citation statements)

References 30 publications

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Section: Discussionmentioning

confidence: 99%

“…The implications of this study lie in the use of hydrocortisone‐based preparations in the daily clinical practice for the treatment of various eye diseases. The penetration capacity of drugs in ophthalmology was a neglected aspect for a long time, but recently, this topic has been addressed by numerous studies and the ability of antibiotics, steroids and NSAIDs to penetrate the anterior chamber has been extensively evaluated 14‐21 …”

Section: Discussionmentioning

confidence: 99%

“…The penetration capacity of drugs in ophthalmology was a neglected aspect for a long time, but recently, this topic has been addressed by numerous studies and the ability of antibiotics, steroids and NSAIDs to penetrate the anterior chamber has been extensively evaluated. [14][15][16][17][18][19][20][21] These studies were often correlated with the definition of therapeutic capabilities of the different compounds to optimise their use and promote a correct therapeutic attitude. 15,[22][23][24] Our results suggest that high concentrations in the eye drops are required to significantly change the concentration of hydrocortisone in the anterior chamber.…”

Section: Discussionmentioning

confidence: 99%

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Kinetics of hydrocortisone sodium phosphate penetration into the human aqueous humor after topical application

Cagini

Muzi

Castellucci

et al. 2021

Int J Clinical Practice

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Aim of the study Hydrocortisone is a soft steroid with low anti‐inflammatory properties and a short duration of action, used to manage several ocular conditions. The clinical benefits and side effects associated with hydrocortisone are well documented, but its basic pharmacokinetic in the eye is yet to be fully elucidated. The purpose of this study is to investigate the anterior chamber penetration capabilities of hydrocortisone when used in different concentrations as eye drops treatment. Materials and Methods This is a double‐blind, single‐centre, randomised clinical trial performed at the Department of Medicine and Surgery of the University of Perugia (Italy) on consecutive patients who undergone phacoemulsification with intraocular lens implantation. Patients were randomly assigned on the morning of surgery to receive a single instillation of 0.33% (group A) or 0.001% (group B) hydrocortisone sodium phosphate solution. Group of patients C did not receive any treatment and was used to measure the hydrocortisone endogenous levels. Before surgery, one aliquot of aqueous humor for each patient was aspirated. The time of collection for each sample was recorded. Hydrocortisone concentrations were then stratified into six interval classes of 30 minutes each. Results The mean concentration of hydrocortisone was significantly higher in group A (25.2 ± 12.4 ng/mL) compared with group B (7.11 ± 1.51 ng/mL) and compared with the mean hydrocortisone endogenous levels (3.92 ± 1.18 ng/mL) (P < .0001). No statistically significant differences of hydrocortisone mean concentrations between group B and the mean endogenous levels were found. Conclusions Considering the frequent need for prolonged topical steroid therapies and the possible consequent undesirable side effects, ophthalmologists should consider the lowest clinically effective dose of hydrocortisone useful to obtain the desired therapeutic effect and in an adequate time, to minimise the amount of steroids into the anterior chamber and to avoid side effects like intra‐ocular pressure increase or cataract development.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Kinetics of hydrocortisone sodium phosphate penetration into the human aqueous humor after topical application

Cagini

Muzi

Castellucci

et al. 2021

Int J Clinical Practice

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“…The purpose of this proposed work was to develop and validate the method using ultraviolet-high performance liquid chromatographic (UV-HPLC) for quantification of besifloxacin hydrochloride. In literature, other analytical methods described for the quantitative analysis of besifloxacin hydrochloride but no report found using UV-HPLC method [3][4][5][6][7][8][9]. The newly developed method was a unique advantage over the other available methods, as it is simple, accurate, precise, and specific for quantitative determination of besifloxacin hydrochloride in pharmaceutical dosage form.…”

Section: Introductionmentioning

confidence: 99%

Uv-HPLC Method Development and Validation for Quantification of Besifloxacin Hydrochloride

Saha

Patel

Halder

2017

Asian J Pharm Clin Res

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Objective: The objective of this investigation was to develop and validates a new, rapid, accurate high performance liquid chromatographic (HPLC) method for the quantification of besifloxacin hydrochloride. Materials and Methods:Isocratic ultraviolet (UV)-HPLC separation was performed using a Zodiac C18 (150 mm × 4.6 mm) column, with 150 volume of acetonitrile and 350 ml of methanol in 500 ml buffer as mobile phase at a flow rate of 2 ml/min and UV detection at 295 nm. Results:The sample found stable for 24 hrs in analyte solution and compatible with a nylon filter. The Beer's law plots were found to be linear over the concentration range 70-130% with a correlation coefficient (r 2 ) 0.9999 in diluent, phosphate buffer, and simulated tear media. The % relative standard deviation was found <2% shows good precision, acceptable accuracy, and reproducibility of the new method for the determination of besifloxacin hydrochloride. Conclusion:The method was validated as per the ICH guidelines. The method is accurate and can be applied for qualitative analysis of besifloxacin hydrochloride in bulk drug and in formulation.

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“…However, the long-term use of the above-mentioned antibiotics has been shown to decrease the sensitivity of bacteria to this set of products. 10,11 Balofloxacin is a newer generation fluoroquinolone with broad-spectrum antibacterial activity against gram-negative, gram-positive, and anaerobic bacteria. Currently, balofloxacin is used for the treatment of respiratory, intestinal, and urinary tract infections through oral administration.…”

Section: Introductionmentioning

confidence: 99%

In VitroandIn VivoEffectiveness Evaluation of Balofloxacin in ExperimentalStaphylococcus aureusKeratitis

Jiang

Han

Guo

et al. 2014

Journal of Ocular Pharmacology and Therapeutics

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Penetration and effectiveness of prophylactic fluoroquinolones in experimental methicillin-sensitive or methicillin-resistant Staphylococcus aureus anterior chamber infections

Abstract: Moxifloxacin had greater in vivo effectiveness against MSSA and MRSA than besifloxacin. The aqueous antibiotic concentrations suggest limited penetration by besifloxacin, accounting for its lack of effectiveness.

Cited by 9 publications

References 30 publications

Kinetics of hydrocortisone sodium phosphate penetration into the human aqueous humor after topical application

Kinetics of hydrocortisone sodium phosphate penetration into the human aqueous humor after topical application

Uv-HPLC Method Development and Validation for Quantification of Besifloxacin Hydrochloride

In VitroandIn VivoEffectiveness Evaluation of Balofloxacin in ExperimentalStaphylococcus aureusKeratitis

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