The demand for rice continues to increase due to population growth each year. This results in higher national food requirements. An approach to boosting rice production is by utilizing high-quality fertilizers and seeds. This study aims to examine the seed quality and vegetative growth of rice production fertilized with NPK and Biosaka in supporting sustainable agriculture. Seed testing was conducted at the Seed Technology Laboratory, and seedling growth testing was carried out in the greenhouse of the Faculty of Agriculture, Universitas Sumatera Utara. This study used a Split Plot Design with 3 replications and 2 treatment factors. The first treatment involved seeds from plants given NPK fertilizer: 0, 150, and 300 kg/ha. The second treatment involved seeds from plants treated with Biosaka: 0, 20, and 40 ml/15 L.. The research results showed that the application of NPK fertilizer at a dose of 300 kg/ha in rice plant growth significantly improved seed quality (growth potential, percentage of normal germination, seed vigor index, root fresh weight, and root dry weight). Meanwhile, the application of Biosaka at a concentration of 40 ml/15L in rice plant growth significantly improved seed quality (growth potential, seed vigor index, and germination rate).