Pengaruh Kondisi Proses Ekstraksi Batang Brotowali (Tinospora crispa (L) Hook.f &amp; Thomson) Terhadap Aktivitas Hambatan Enzim Alfa Glukosidase

Rosidah, Idah; Bahua, Humiaty; Mufidah, Rima; Pongtuluran, Olivia Bunga

doi:10.22435/mpk.v25i4.4586.203-210

Cited by 3 publications

(2 citation statements)

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“…11 The time or length of the extraction process determines the content of the compound that comes out of the material, as well as the ratio of the solvent, the amount of extractant involved in the transfer determines the level of concentration difference which is very important in the diffusion process that affects the compound content. 12 Percolation is a cold extraction method that does not affect the temperature of the process. By using the percolation extraction method, it is hoped that the active compounds contained in the liver tubers are not damaged.…”

Section: Resultsmentioning

confidence: 99%

The Serum Formulation of Hati Tanah Tuber Ethanol Extract from Central Kalimantan

Qamariah¹,

Handayani²,

Maretania³

2023

Pharmacogn J.

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Introduction: Lately, the use of natural cosmetics can have a good effect on the skin. One of them is traditional beauty treatments. The Serum is a preparation with low viscosity, because of its low viscosity serum is categorized as an emulsion preparation. From the results of research that has been carried out, ethanol extract of Hati Tanah tuber has great potential as an anti-acne because it can inhibit the growth of acne-causing bacteria such as Staphylococcus aureus, Staphylococcus epidermidis, Propionibacterium acnes. With the innovation of serum ethanol extract of Hati Tanah tuber, it can be an option for the community later in the treatment of acne. Methods: The formulation is made in 4 (four) formulas with different concentrations of the main ingredients used. Next is to weigh all the ingredients needed according to each formula. Then physical properties test performed. a) Organoleptic test; b) Homogeneity Test; c) pH test; d) Spreadability Test and e) Adhesion Test. Results: The organoleptic test was carried out directly by looking at the shape and color and smelling the serum preparation of the ethanol extract of Tanah Hari tubers. The test results show that at F0 (0%) the color is clear, for F1 (0,5%) it is quite pale pink, F2 (1%) is bright pink and F3 (5%) is dark red. For scent organoleptic, F0 indicates no scent, for F1 and F2 there is a distinctive scent from the Hati Tanah tuber which is slightly pungent, while F3 shows a pungent aroma typical of the Hati Tanah tuber. The resulting serum has a thick texture at F0 and F1, a watery texture at F2 and a thinner texture at F3. All of the formulas have met the physical test requirement of organoleptic properties, homogeneity, pH, and adhesion test. Conclusion: The simplicia of Hati Tanah tuber can be made into an innovative cosmetic preparation in the form of serum with a concentration of 0,5%, 1% and 5%. From the results of testing the physical properties of the formulations, all of the formulas have met the physical test requirement of organoleptic properties, homogeneity, pH, and adhesion test.

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Section: Resultsmentioning

confidence: 99%

The Serum Formulation of Hati Tanah Tuber Ethanol Extract from Central Kalimantan

Qamariah¹,

Handayani²,

Maretania³

2023

Pharmacogn J.

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show abstract

“…This process can be easily upgraded on a lab, pilot, or larger scale, like for a manufacturer. Despite the extraction technique, the extract's quality can be affected by many other factors, such as time of extraction, temperature, type and concentration of the solvent, and the solid-liquid ratio between the dry sample and solvent (13).…”

Section: Introductionmentioning

confidence: 99%

Optimization of extraction condition of Gynura procumbens extract enriched with flavonoid and antioxidant compounds using Response Surface Methodology

PERMATASARİ

PURWATİ²,

BAHUA

et al. 2023

Journal of the Turkish Chemical Society Section A: Chemistry

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Gynura procumbens is known as one of the herbal medicinal plants found in Indonesia and has been used from time to time. It is claimed to have various efficacy such as anti-hyperglycemic, anti-hypertension, anti-microbial, anti-cancer, and antioxidant. Other studies mention that G. procumbens possessed high antioxidant compounds and had been used as a natural-based medicinal supplement. However, further studies on optimizing the extraction process of Gynura procumbens in Indonesia have yet to be reported. Therefore, this study aimed to optimize the extraction condition of G. procumbens leaves by maceration with three variables: solvent concentration, extraction time, and the ratio of solid-liquid used. Each of those variables contained three different levels. Determination of total flavonoid and antioxidant activity was measured using aluminium chloride colourimetric assay and 2, 2-diphenyl-1-picryl-hydrazil (DPPH) assay, respectively. In the optimization process, Response Surface Methodology (RSM) was used to explore the main effects and interaction between parameters and their correlations with dependent variables. The results were analyzed using the Box-Behnken method using Minitab software 17. This study shows that the most significant effect of the variable for both flavonoid and antioxidant activity was solvent concentration, with a P<0.05. The results showed that the extraction process to obtain G. procumbens extract with optimal flavonoid content and antioxidant activity (IC50) was predicted at 70% solvent concentration, 1 h maceration time, and a solid-liquid ratio of 1:9.8 w/v, with results of 17.599 mg QE/g extract and 0.211 mg/mL, respectively. This study was expected to complement other studies and can be used as an additional reference for the development of the extraction process on a larger scale.

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In silico screening of brotowali (Tinospora crispa L.) chemical compounds as α-glucosidase inhibitor using the pyrx program

Tahir¹,

Baharuddin²,

Najib³

2023

Iwosp 2021, International Workshop on Statistical Physics

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Pengaruh Kondisi Proses Ekstraksi Batang Brotowali (Tinospora crispa (L) Hook.f & Thomson) Terhadap Aktivitas Hambatan Enzim Alfa Glukosidase

Cited by 3 publications

References 0 publications

The Serum Formulation of Hati Tanah Tuber Ethanol Extract from Central Kalimantan

The Serum Formulation of Hati Tanah Tuber Ethanol Extract from Central Kalimantan

Optimization of extraction condition of Gynura procumbens extract enriched with flavonoid and antioxidant compounds using Response Surface Methodology

In silico screening of brotowali (Tinospora crispa L.) chemical compounds as α-glucosidase inhibitor using the pyrx program

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