Pengaruh Pemberian Ekstrak Etanol Daun Dandang Gendis (Clinacanthus nutans (Burm F) Lindau)  Terhadap Daya Analgetik Dan Gambaran Makroskopis Lambung Mencit

Klau, Maria Happy Christian; Hesturini, Rosa Juwita

doi:10.52216/jfsi.v4i1.59

Cited by 3 publications

(2 citation statements)

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“…Determination was carried out in the biology laboratory of IAIN Syekh Nurjati Cirebon to compare one plant with another and determine the correctness of the samples used in the study (Klau & Hesturini, 2021).…”

Section: Results and Discussion Plant Determinationmentioning

confidence: 99%

ANALGESIC POWER OF THE INSOLUBLE FRACTION N-HEXANE OF MELINJO LEAVES (Gnetum gnemon L.) IN SWISS MICE (Mus musculus)

Firmansyah,

Amelia,

Indriaty

et al. 2023

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Melinjo (Gnetum gnemon L.) contains various secondary metabolites, including alkaloids, flavonoids, saponins, and tannins. Flavonoids function as analgesics and inhibit cyclooxygenase enzymes, which reduce prostaglandin production and pain. This study aimed to determine the analgesic power of the n-hexane-insoluble fraction of melinjo leaves (Gnetum gnemon L.) as an effective analgesic in male white mice (Mus musculus) and to determine the most effective analgesic dose. This research was conducted using test animals of 25 male white mice (Mus musculus) divided into 5 groups, each consisting of 5 mice. The negative control group (Na-CMC) was 0.5%, the positive control group received a mefenamic acid dose of 65 kg/BW, and the insoluble fraction hexane group (ifh) received doses of 50 mg/kg BW, 100 mg/kg BW, and 200 mg/kg BW. The chemical stimulus was administered at a dose of 400 mg/kg body weight acetic acid. The number of wriggles in male white mice (Mus musculus) was measured every 10 minutes for 60 minutes. The results of the study showed a significant difference between the negative control (Na-CMC 0.5%) and various doses of insoluble fraction hexane groups, while the positive control (mefenamic acid 65 mg/kg BB) showed no difference with ifh doses of 100 mg/kg BB and 200 mg/kg BB ...

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Section: Results and Discussion Plant Determinationmentioning

confidence: 99%

ANALGESIC POWER OF THE INSOLUBLE FRACTION N-HEXANE OF MELINJO LEAVES (Gnetum gnemon L.) IN SWISS MICE (Mus musculus)

Firmansyah,

Amelia,

Indriaty

et al. 2023

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“…Simplisia daun teh hijau (Camellia sinensis (L). O Kuntze) yang telah diperoleh dari Pusat Penelitian Teh dan Kina (PPTK) dilakukan proses determinasi, tujuan dilakukan determinasi terhadap bahan yang diperoleh adalah untuk mengetahui kebenaran tanaman yang akan diteliti dan menghindari kesalahan dalam pengumpulan bahan serta menghindari kemungkinan tercampurnya tanaman yang akan diteliti dengan tanaman lain (22). Daun teh hijau kemudian dihaluskan dengan menggunakan blender hingga menjadi serbuk atau partikel dengan ukuran yang kecil.…”

Section: Pengumpulan Dan Penyiapan Simplisia Daun Teh Hijau (Camellia...unclassified

Uji Aktivitas Antioksidan Dan Inhibitor Tirosinase Ekstrak Etanol Daun Teh Hijau

Fitri Mellyna Cantika,

Sani Ega Priani

2023

JRF

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Abstract. Skin is the outermost organ of the body that plays a role in the process of protection from UV radiation, which can cause the formation of free radicals and hyperpigmentation. Green tea leaves (Camellia sinensis (L) O. Kuntze) contain high polyphenol compounds, especially epigallocatechin gallate, which has potential as an antioxidant and tyrosinase inhibitor. This study aims to determine the antioxidant activity and tyrosinase inhibition in ethanol extract of green tea leaves. Ethanol extract of green tea leaves was obtained by reflux method using 96% ethanol solvent. Antioxidant activity test and tyrosinase inhibitor using DPPH method and dopachrome method based on enzymatic colorimetric testing. Antioxidant activity test results showed that green tea leaf extract has an IC50 value of 2.349 ppm, and has tyrosinase inhibitory activity with an IC50 value of 1000.422 ppm. Abstrak. Kulit merupakan organ tubuh terluar yang berperan dalam proses pelindungan dari radiasi sinar UV, yang dapat menyebabkan pembentukan radikal bebas dan hiperpigmentasi. Daun teh hijau (Camellia sinensis (L) O. Kuntze) mengandung senyawa polifenol yang tinggi khususnya epigallocatechin gallate yang berpotensi sebagai antioksidan dan inhibitor tirosinase. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dan penghambatan tirosinase pada ekstrak etanol daun teh hijau. Ekstrak etanol daun teh hijau diperoleh dengan metode refluks menggunakan pelarut etanol 96%. Uji aktivitas antioksidan dan inhibitor tirosinase menggunakan metode DPPH dan metode dopakrom berbasis pengujian kolorimetri enzimatik. Hasil uji aktivitas antioksidan menunjukan bahwa ekstrak daun teh hijau memiliki nilai IC50 2,352 ppm, dan memiliki aktivitas penghambatan tirosinase dengan nilai IC50 1000,422 ppm.

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Characterisation of Maclura cochinchinensis (Lour.) Corner Trunk Heartwood Extract and its Toxicity Evaluation

Mumpuni,

Kurniawati,

Djamil

et al. 2024

JoP

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Introduction: Maclura cochinchinensis is widely used as a natural dye for clothing in Indonesia. Besides, there are some researches about its activities as an antioxidant, antimicrobial, and antidiabetic. However, there is a lack of comprehensive information regarding the standard characteristics and safety of use of its heartwood extract. Therefore, this study aimed to characterize M. cochinchinensis heartwood extract and to evaluate its toxicity. Method: To obtain the extract, coarse powder of M. cochinchinensis heartwood was macerated using 70% ethanol and evaporated by vacuum rotavapor. Subsequently, phytochemical screening and thin-layer chromatography profiling were carried out, while the toxicity evaluation was conducted using brine shrimp lethality test. Results: The phytochemical screening showed that this extract contained flavonoids, saponins, tannins, steroids, triterpenoids, coumarins, and essential oils. The extract exhibited a dark brown colour, distinct odour, flavourlessness, the value of water-soluble content, ethanol-soluble extract content, loss on drying, moisture content, moisture content, total ash content, acid-insoluble ash content, and water-soluble ash content of 31.44%±1.31, 50.44%±8.48, 9.51%±0.32, 1.62%±0.48, 4.93%±0.27, 1.10%±0.11, 3.81%±0.19, respectively. The residual solvent and heavy metal contamination were undetectable. Microbial contamination was minimal and dominated by a semipolar compound, and brine shrimp assay indicated low toxicity with an LC50 value of 174.40 mg/L. Conclusion: M. cochinchinensis heartwood extract has good quality and tends to be safe for the environment. This research obtained data that could be used as a supporting evidence for more specific utilization of M. cochinchinensis heartwood and its isolated compounds.

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Pengaruh Pemberian Ekstrak Etanol Daun Dandang Gendis (Clinacanthus nutans (Burm F) Lindau) Terhadap Daya Analgetik Dan Gambaran Makroskopis Lambung Mencit

Cited by 3 publications

References 0 publications

ANALGESIC POWER OF THE INSOLUBLE FRACTION N-HEXANE OF MELINJO LEAVES (Gnetum gnemon L.) IN SWISS MICE (Mus musculus)

ANALGESIC POWER OF THE INSOLUBLE FRACTION N-HEXANE OF MELINJO LEAVES (Gnetum gnemon L.) IN SWISS MICE (Mus musculus)

Uji Aktivitas Antioksidan Dan Inhibitor Tirosinase Ekstrak Etanol Daun Teh Hijau

Characterisation of Maclura cochinchinensis (Lour.) Corner Trunk Heartwood Extract and its Toxicity Evaluation

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