Pengaruh Pemberian Ekstrak Kulit Pisang Kepok terhadap Histologi Ginjal, Kadar Ureum dan Kreatinin Tikus Putih setelah Melakukan Latihan Intensif

Astawibawa, Putu Oky; Suarsana, I Nyoman; Suartini, I Gusti Ayu Agung

doi:10.24843/bulvet.2022.v14.i05.p18

Cited by 2 publications

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“…Low urea is not considered abnormal, because it may be caused by low protein in the food consumed. 13,18 Foods high in protein can increase the release of amino acids into the blood and reabsorb in the proximal tubule. Because amino acids and sodium are reabsorbed together from the proximal tubule, increased amino acid reabsorption stimulates sodium reabsorption in the proximal tubule.…”

Section: Discussionmentioning

confidence: 99%

TOXICITY TEST OF IRONWOOD BARK EXTRACT (Eusideroxylon zwageri) TOWARD WISTAR RATS KIDNEY (Rattus norvegicus)

Arum¹,

Firdaus²,

Oktiani³

2023

Dentino

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Background: The use of herbal medicinal plants by the community is increasing because the side effects are smaller than chemical-based drugs. One of the medicinal plants is ironwood because of its flavonoid and phenolic compounds which have the potential as antioxidants. Ironwood needs to be known for its toxicity, by performing an oral subchronic toxicity test on the kidneys of wistar rats with urea and creatinine parameters. Objective: Proving that the administration of ironwood bark extract at doses of 524.5 mg/mL, 1151.5 mg/mL, and 1775.5 mg/mL orally for 28 days had no toxic effect on the kidneys of wistar rats with parameters of urea and creatinine. Methods: Pure experimental research with posttest-only with control group design, consisting of 4 groups, each of which contained 4 wistar rats with 1 negative control group and 3 treatment groups given ironwood bark extract at a dose of 524.5 mg/mL, 1151, 5 mg/mL, and 1775.5 mg/mL. It was carried out for 28 days and on the 29th day the rats were taken blood and examined for urea and creatinine levels. Results: In the 3 treatment groups, urea values were 41, 42, and 32.35 mg/dL and creatinine was 0.725, 0.725, and 0.65 mg/dL and the results also showed that there was no significant difference in urea levels (p=0.076) and creatinine (p=0.076). 0.065) in each group. Conclusion: Ironwood bark extract dose 524.5 mg/mL, 1151.5 mg/mL, and 1775.5 mg/mL was not toxic to the kidneys of wistar rats with parameters of urea and creatinine. Keywords: Creatinine, Ironwood bark extract, Toxicity, Urea.

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Section: Discussionmentioning

confidence: 99%

TOXICITY TEST OF IRONWOOD BARK EXTRACT (Eusideroxylon zwageri) TOWARD WISTAR RATS KIDNEY (Rattus norvegicus)

Arum¹,

Firdaus²,

Oktiani³

2023

Dentino

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“…Serum creatinine and urea are the standard parameters to measure kidney function. Creatinine is a waste product of creatinine phosphate metabolism formed in the muscles, while urea is produced in the liver from amino acids (Astawibawa et al, 2022). Elevated levels of creatinine and urea show potential damage and a decline in kidney function.…”

Section: Introductionmentioning

confidence: 99%

Nephrotoxicity effect of Ginseng Bugis (Talinum paniculatum (Jacq) Gaertn) leaves ethanolic extract on creatinine, urea, and kidney histopathological features

Emelda,

Santi,

Besse

et al. 2024

IFRJ

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The prolonged use of traditional medicines in large doses is known to potentially cause organ failure, with the kidneys being particularly susceptible. Therefore, the present work aimed to determine the effect of Talinum paniculatum (Jacq.) Gaertn leaves ethanolic extract on serum creatinine and urea parameters, as well as kidney histopathological features, in an animal model. The rats used were separated into four groups. Group I (control) was given Na-CMC 1% (w/v); while groups II, III, and IV were administered ethanolic extract of Ginseng Bugis leaves at doses of 0.8, 1.6, and 2.4 g/kg bw, respectively. The extract was induced orally for 28 days, while the serum creatinine and urea levels were measured using human analyser on days 0 and 29. Additionally, a necropsy for organ retrieval of the kidneys was conducted on day 15. Tissue processing was then carried out for histopathological examination by Haematoxylin Eosin (HE) staining. Based on One way ANOVA statistical analysis on creatinine and urea levels, ethanolic extract of Ginseng Bugis leaves at doses of 0.8, 1.6, and 2.4 g/kg bw had no nephrotoxic effects. Regarding the histopathological features of the kidneys, the dose of 0.8 g/kg bw caused no abnormalities.

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Pengaruh Pemberian Ekstrak Kulit Pisang Kepok terhadap Histologi Ginjal, Kadar Ureum dan Kreatinin Tikus Putih setelah Melakukan Latihan Intensif

Cited by 2 publications

References 0 publications

TOXICITY TEST OF IRONWOOD BARK EXTRACT (Eusideroxylon zwageri) TOWARD WISTAR RATS KIDNEY (Rattus norvegicus)

TOXICITY TEST OF IRONWOOD BARK EXTRACT (Eusideroxylon zwageri) TOWARD WISTAR RATS KIDNEY (Rattus norvegicus)

Nephrotoxicity effect of Ginseng Bugis (Talinum paniculatum (Jacq) Gaertn) leaves ethanolic extract on creatinine, urea, and kidney histopathological features

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