PENGARUH PEMBERIAN EKSTRAK KUNYIT TERHADAP GAMBARAN HISTOPATOLOGI AORTA TIKUS WISTAR (rattus novergicus) HIPERLIPIDEMIA

Thendry, Anggelina; Loho, Lily; Lintong, Poppy M.

doi:10.35790/ebm.3.1.2015.6638

Cited by 4 publications

(5 citation statements)

References 4 publications

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“…The results of this study indicated that a significant increase in the number of foam cells was found in the negative control group, atherosclerosis occurs in rats after a high-fat diet for 30 days (Loho & Lintong, 2015). The large number of foam cells is an early sign and pathognomonic of an atherosclerotic state.…”

Section: Discussionmentioning

confidence: 56%

Effect of Celery Extract Administration on 8-OHdG and Number of Foam Cell in Wistar Strain Rats With A High-Fat Diet

Budiarto

Nasihun²,

Hussaana³

2018

Sains Med. J. Kedokt. dan Kesehat.

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BACKGROUND: A high fat diet, accompanied by high frequency eating, results in hyperlipidemia. One prevention for hyperlipidemia is administration of celery extract.OBJECTIVE: to explore the effect of celery extract on the level of 8-OHdG (8 -Hydroxy-2’-Deoxy Guanosine) and the number of foam cell.METHODS: Experimental studies with post-test only control group design used Wistar rats, administered with adrenaline and high-fat diet forhyperlipidemic induction.Total of 35 rats were divided into 5 groups: negative controls (Neg-G); positive control treated with simvastatin (Nor-G); ES25-G,ES50-G, and ES75-G group were treated with 25 mg/200 g BW, 50 mg/200 g BW, and 75 mg/200 g BW celery extract, respectively. The treatment was given for 30 days. The 8-OHdG level was determined by ELISA, whereas the number of foam cells was determined by histopathologic preparations with HE staining. Data analysis was conducted by Kruskal-Wallis and Mann-Whitney.RESULTS: Mann-Whitney analysis showed levels of 8-OHdG in ES-25-G 12.13±0.21, ES-50-G 7.23±0.25, ES-75-G 4.41±0.45 significantly lowerthan the Nor-G 14.30±0.66, respectively p<0.001. The number of foam cells in the ES-25-G was 7.57±0.53, ES-50-G 6.57±0.79, ES-75-G 3.43±0.53,significantly lower than the Neg-G 13.57±1.27, respectively p<0.001.CONCLUSION: Celery extract capable of decreasing levels of 8-OHdG and the number of foam cells in Wistar rats induced with adrenaline and high-fatdiet.

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Section: Discussionmentioning

confidence: 56%

Effect of Celery Extract Administration on 8-OHdG and Number of Foam Cell in Wistar Strain Rats With A High-Fat Diet

Budiarto

Nasihun²,

Hussaana³

2018

Sains Med. J. Kedokt. dan Kesehat.

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“…The research was conducted by giving a high-fat diet in the form of duck egg yolks and margarine. According to research by [36][37] white rats that were given 2 g duck egg yolk per day for 28 days and 5 gram of margarine per day for 28 days experienced a resulting increase in total cholesterol and triglyceride levels and microscopically visible intima foam cells and aortic media [36][37]. Hyperlipidemia conditions can cause endothelial dysfunction so that LDL can more easily enter the walls of blood vessels and can increase the production of oxygen free radicals and can cause LDL to be oxidized to LDL-ox.…”

Section: Microscopic Observation Results Of Aorta Of Atherosclerotic ...mentioning

confidence: 99%

The Cardioprotective Effect of Polysaccharide Sulphate Isolated from Brown Algae (Sargassum polycystum)

Marzaman,

Amir,

Ramadhan

et al. 2024

BIO Web Conf.

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The incidence of atherosclerosis is characterized by an increase in the value of low-density lipoprotein (LDL) and a decrease in the value of high-density lipoprotein (HDL) as well as an increase in the total white blood cell count which can indicate the occurrence of atherosclerosis. This study used 18 rats which were divided into 6 groups of 3 each, namely a normal control group, a negative control group (CMC 0.5%), a positive control group (Simvastatin 20 mg/kg BW), and 3 groups given a sulfate polysaccharide isolate compound test material (dosage of 250, 50, and 10 mg/kg of body weight). The results showed that sulfated polysaccharide isolates had an effect in reducing white blood cells significantly between doses of 250 mg/kg BW and 50 mg/kg BW as well as reducing SGOT levels. Unfortunately it did not reduce the SGPT level. The results of the Mann-Whitney post hoc test showed that administration of sulfated polysaccharides at an optimal dose of 250 mg/kg BW reduced the number of foam cells in the atherosclerotic white rats' (Rattus norvegicus) aortas that were given a high-fat diet and had activity in reducing CKMB levels compared to other doses.

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“…The accumulation of LDL on blood vessel walls could be cell foam. 2 The high fatty diet was the food which compounds fat, and it can make the stress oxidation inside of the body. 2 Stress oxidative caused by free radical which binding with another compound to make a stable compound and could destroy another macromolecule, like the cell membrane of lipid, DNA and protein.…”

Section: Introductionmentioning

confidence: 99%

“…2 The high fatty diet was the food which compounds fat, and it can make the stress oxidation inside of the body. 2 Stress oxidative caused by free radical which binding with another compound to make a stable compound and could destroy another macromolecule, like the cell membrane of lipid, DNA and protein. 3 It could increase blood lipid, which is cholesterol and triglyceride level, which called hyperlipidemia.…”

Section: Introductionmentioning

confidence: 99%

The potency of green grass jelly extract (Premna oblongifolia Merr) as antihyperlipidemia towards aorta histopathology representation of rat (Rattus norvegicus) induced with high fatty diet (HFD)

et al. 2020

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Green grass jelly (Premna oblongifolia merr) is a plant containing fiber and chlorophyll which can lower cholesterol and triglyceride levels. This study have aims to investigate the potency of green grass jelly extract (Premna oblongifolia Merr) to prevent hyperlipidemia. The animal mode used for this study is male Rattus norvegicus, Wistar strain, the age of 8 weeks, and weight of 200 g which is divided into 5 groups of treatment namely group Kn (negative control), Kp (positive control), Kp1, Kp2, and Kp3 induced with HFD and green grass jelly extract at a dose of 5.27 g/ kg BW/ daily, 8.43 g/ kg BW/ daily, 9.37 g/ kg BW/ daily. The data of infiltrating fatty cells and macrophage on aorta histopathology was analyzed by description. This research showed that the treatment of green grass jelly extract (Premna oblongifolia Merr) to animals of hyperlipidemia model reduced infiltration fatty cells and macrophage. The conclusion of this study was the green grass jelly extract was able to prevent an increase of fatty cells and macrophage infiltration of rat (Rattus noervegicus) induced with HFD on dose 9.37 g/ kg/ BW/ daily.

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PENGARUH PEMBERIAN EKSTRAK KUNYIT TERHADAP GAMBARAN HISTOPATOLOGI AORTA TIKUS WISTAR (rattus novergicus) HIPERLIPIDEMIA

Cited by 4 publications

References 4 publications

Effect of Celery Extract Administration on 8-OHdG and Number of Foam Cell in Wistar Strain Rats With A High-Fat Diet

Effect of Celery Extract Administration on 8-OHdG and Number of Foam Cell in Wistar Strain Rats With A High-Fat Diet

The Cardioprotective Effect of Polysaccharide Sulphate Isolated from Brown Algae (Sargassum polycystum)

The potency of green grass jelly extract (Premna oblongifolia Merr) as antihyperlipidemia towards aorta histopathology representation of rat (Rattus norvegicus) induced with high fatty diet (HFD)

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