Application of goat manure organic fertilizer in liquid form can optimize the growth of vanilla cuttings. The objective of the research was to obtain the best concentration and frequency of POC goat manure fertilization on vanilla cuttings. This study used factorial RBD which was repeated 3 times. The first factor was the concentration of goat manure liquid organic fertilizer consisting of K1 = 50 PPM, K2 = 100 PPM, K3 = 150 PPM and K4 = 200 PPM. The second factor was the frequency of fertilizing goat manure liquid organic fertilizer consisting of K1 = 1 time, K2 = 2 times, and K3 = 3 times. Observations were made on vine length, stem dimater, number of leaves, number of internodes, and degree of greenness of the leaves. The results showed that the best concentration of goat manure liquid organic fertilizer was at a concentration level of 200 PPM and the best frequency of goat manure liquid organic fertilizer was once a week for all research observation variables..