PENGARUH SINBIOTIK KEFIR TEPUNG PISANG BATU (&lt;em&gt;Musa balbisiana&lt;/em&gt;) TERHADAP KADAR GLUKOSA DARAH TIKUS SINDROM METABOLIK

Salsabila, Dhea Marliana; Maryusman, Taufik; Fatmawati, Iin

doi:10.29122/jbbi.v7i1.3730

Cited by 3 publications

(7 citation statements)

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“…Dosis Kelompok kontrol positif adalah tikus sindrom metabolik yang diberikan obat standar, Kelompok kontrol negatif adalah tikus sindrom metabolik diberi pakan standar, kelompok ekstrak dosis 1,2 dan 3 diberikan sediaan kombinasi kombinasi ekstrak Hibiscus Sabdariffa L dan Momordica Charantia dengan dosis perbandingan (75 %: 25 %), (50 %: 50 %) dan (25 %: 75 %) selama tiga minggu (Herdiani, 2020;Haufe et al, 2019;Imanda, et al, 2019). Pengkondisian sindrom metabolik dilakukan selama dua minggu dengan pemberian High fat fructose diet (HFFD), fruktosa (konsentrasi fruktosa) murni 1 mL 200 g¹ ‫-‬ BB tikus per hari, kuning telur bebek 1 mL 200 g¹‫-‬ BB tikus per hari, dan minyak babi 2 mL 200 g¹‫-‬ BB tikus per hari (Salsabila et al, 2020). Subjek dinyatakan Sindrom Metabolik ketika terjadi kadar Glukosa Darah Puasa (GDP) > 71,02 mg/dl,dan kadar trgliserida > 67,60 mg/dl serta kadar HDL < 78,66 mg/dl (Salsabila et al, 2020;Maryusman et al, 2021).…”

Section: Pengelompokkan Hewan Coba Dan Lama Perlakuanunclassified

“…Pengkondisian sindrom metabolik dilakukan selama dua minggu dengan pemberian High fat fructose diet (HFFD), fruktosa (konsentrasi fruktosa) murni 1 mL 200 g¹ ‫-‬ BB tikus per hari, kuning telur bebek 1 mL 200 g¹‫-‬ BB tikus per hari, dan minyak babi 2 mL 200 g¹‫-‬ BB tikus per hari (Salsabila et al, 2020). Subjek dinyatakan Sindrom Metabolik ketika terjadi kadar Glukosa Darah Puasa (GDP) > 71,02 mg/dl,dan kadar trgliserida > 67,60 mg/dl serta kadar HDL < 78,66 mg/dl (Salsabila et al, 2020;Maryusman et al, 2021). Subyek ditetapkan mengalami sindrom metabolik ketika glukosa darah puasa (GDP) dan trigliserida (TG) meningkat dan kadar HDL menurun (Salsabila et al, 2020).…”

Section: Pengelompokkan Hewan Coba Dan Lama Perlakuanunclassified

“…Subjek dinyatakan Sindrom Metabolik ketika terjadi kadar Glukosa Darah Puasa (GDP) > 71,02 mg/dl,dan kadar trgliserida > 67,60 mg/dl serta kadar HDL < 78,66 mg/dl (Salsabila et al, 2020;Maryusman et al, 2021). Subyek ditetapkan mengalami sindrom metabolik ketika glukosa darah puasa (GDP) dan trigliserida (TG) meningkat dan kadar HDL menurun (Salsabila et al, 2020).…”

Section: Pengelompokkan Hewan Coba Dan Lama Perlakuanunclassified

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Potensi Kombinasi Pemberian Ekstrak Rosella dan Pare Menurunkan Kadar Glukosa Darah dan Meningkatkan Kolesterol-HDL pada Tikus Model Sindrom Metabolik

Kasimo,

Savitri,

Kadir

et al. 2023

j.kesehatan metro sai wawai

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Latar Belakang: Sindrom metabolik merupakan salah satu masalah kesehatan yang meningkat saat ini. Sindrome metabolik akan meningkatkan risiko diabetes melitus tipe 2 dan kardiovaskuler. Penyakit ini menjadi ancaman kesehatan sehingga dibutuhkan kombinasi obat dalam menangani berbagai gangguan disfungsi. Terapi obat kimia tidak cukup menyembuhkan atau menghentikan perkembangan penyakit. Tanaman Rosella dan pare memiliki aktifitas sebagai hipoglikemik dan antilipidemik. Tujuan: Untuk mengetahui efek kombinasi ekstrak rosella dan pare dalam menurunkan kadar glukosa darah puasa dan meningkatkan kadar HDL terhadap tikus model sindrom metabolik. Metode: Rancangan penelitian yang digunakan adalah Rancangan Acak Lengkap (RAL) dengan sampel penelitian dibagi dalam 5 kelompok perlakuan. Analisis data dengan uji paired T Test. Tahapan pelaksanaannya yaitu pengkondisian tikus sindrom metabolik. Hasil: Pada kelompok PII didapatkan penurunanan kadar glukosa darah puasa yang signifikan setelah intervensi sebesar 37,43 % (p value = 0,001). Pada kelompok PII didapatkan peningkatan kadar HDL yang signifikan setelah interveni 48,95 % (p value = 0,005) Simpulan: Potensi kombinasi pemberian ekstrak rosella dan pare mampu menurunkan kadar glukosa darah puasa dan meningkatkan kadar HDL tikus model sindrom metabolik. Simpulan: Kadar glukosa darah puasa tikus model sindrom metabolik menurun dan kadar HDL meningkat setelah diberikan intervensi kombinasi ekstrak rosella dan pare. Tahap lanjutan studi adalah untuk mengetahui uji toksisitas akut penggunaan rosella dan pare. Abstract: The potency of Combination of Rosella and Bitter Gourd Extracts to Reduce Blood Glucose Levels and Increase HDL-Cholesterol in Metabolic Syndrome Model Rats. Background: Metabolic syndrome is one of the increasing health problems today. The metabolic syndrome will increase the risk of type 2 diabetes mellitus and cardiovascular disease. This disease is a health threat that requires a combination of drugs to treat various dysfunction disorders. Chemical drug therapy is not enough to cure or stop the progression of the disease. Rosella and bitter melon plants have activities as hypoglycemic and antilipidemic. Purposes: To determine the effect of a combination of rosella and bitter melon extracts in reducing fasting blood glucose levels and increasing HDL levels in metabolic syndrome model rats. Methods: The research design used was a completely randomized design (CRD) with the research sample divided into 5 treatment groups. Data analysis with paired T-test. The stages of implementation are conditioning of metabolic syndrome rats. Result: In group PII, there was a significant decrease in fasting blood glucose levels after intervention by 37.43% (p-value = 0.001). In group PII, there was a significant increase in HDL levels after the intervention of 48.95% (p-value = 0.005) Conclusion: After receiving a mixture of rosella and bitter melon extracts, rats with the metabolic syndrome model had lower fasting blood glucose levels and higher levels of HDL. The next stage of the study was to determine the acute toxicity test of using rosella and bitter melon.

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Section: Pengelompokkan Hewan Coba Dan Lama Perlakuanunclassified

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Potensi Kombinasi Pemberian Ekstrak Rosella dan Pare Menurunkan Kadar Glukosa Darah dan Meningkatkan Kolesterol-HDL pada Tikus Model Sindrom Metabolik

Kasimo,

Savitri,

Kadir

et al. 2023

j.kesehatan metro sai wawai

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“…Nonfarmakoterapi memberikan alternatif pangan fungsional (Salsabila et al, 2020) untuk membantu mengontrol kadar glukosa darah melalui peran aktivitas antioksidan. Flavonoid memiliki aktivitas antioksidan yang berperan dalam mendonorkan atom hidrogen (Lee et al, 2020).…”

Section: Pendahuluanunclassified

Aktivitas Antioksidan Dan Total Flavonoid Es Krim Naga Merah Dan Lidah Buaya Sebagai Nonfarmakoterapi Dmt2

Salsabila¹,

Alifiani²,

Islam³

et al. 2022

jtepakes

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ABSTRAK: Resistensi insulin merupakan tanda dari DMT2 yang disebabkan adanya radikal bebas yang membentuk senyawa oksigen reaktif sehingga terjadi ketidakseimbangan radikal bebas dengan antioksidan dalam tubuh. Nonfarmakoterapi memberikan alternatif pangan fungsional untuk mengontrol kadar glukosa darah pada DMT2 melalui peran antioksidan. Antioksidan pada naga merah dan lidah buaya dapat berikatan dengan radikal bebas sehingga aktivitasnya dapat dihambat. Penelitian ini bertujuan untuk menentukan formulasi terpilih, mengetahui kadar proksimat, aktivitas antioksidan, dan total flavonoid es krim naga merah dan lidah buaya. Penentuan formulasi terpilih menggunakan metode uji organoleptik untuk selanjutnya dilakukan analisis proksimat menggunakan metode kjeldahl, soxhlet, gravimetri, dan by difference, analisis aktivitas antioksidan menggunakan metode DPPH, dan analisis total flavonoid menggunakan metode AlCl₃. Hasil menunjukkan formulasi buah naga merah dan lidah buaya dengan perbandingan sebesar 560 g : 210 g sebagai formulasi terpilih. Hasil analisis proksimat menunjukkan kadar protein 4,05%, lemak 3,96%, air 65,11%, abu 0,88%, dan karbohidrat 25,98%. Aktivitas antioksidan yang kuat (IC₅₀ sebesar 73,42 ppm) dan total flavonoid sebesar 10,54 mg/100g pada es krim naga merah dan lidah buaya menunjukkan potensi sebagai nonfarmakoterapi untuk membantu mengontrol kadar glukosa darah DMT2.ABSTRACT:Insulin resistance is a sign of T2DM caused by the presence of free radicals that form reactive oxygen compounds, resulting in an imbalance of free radicals with antioxidants in the body. Non-pharmacotherapy provides an alternative functional food to control blood glucose levels in T2DM through the role of antioxidants. Antioxidants in Hylocereus costaricensis and Aloe vera L can bind to free radicals so that their activity can be inhibited. This study aims to determine the selected formulation, proximate levels, antioxidant activity, and total flavonoids in Hylocereus costaricensis and Aloe vera L. ice cream. Determination of the selected formulation using the organoleptic test method for further proximate analysis using the kjeldahl, soxhlet, gravimetric, and by difference methods, analysis of antioxidant activity using the DPPH method, and analysis of total flavonoids using the AlCl₃ method. The results showed the formulation of Hylocereus costaricensis and Aloe vera L with a ratio of 560 g : 210 g as the selected formulation. The results of the proximate analysis showed that the protein content was 4.05%, fat was 3.96%, water was 65.11%, ash was 0.88%, and carbohydrate was 25.98%. Strong antioxidant activity (IC₅₀ 73.42 ppm) and total flavonoids of 10.54 mg/100g in Hylocereus costaricensis and Aloe vera L ice cream showed potential as non-pharmacotherapy to help control blood glucose levels of T2DM.

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“…During the adaptation, rats were given standard comfeed of 20g/200gBW/day, drinking water ad libitum, and induction of a high-fat diet (HFD) for 14 days. The composition of the HFD induction consisted of 2 ml/200gBW pork oil and 1 ml/200gBW duck egg yolk administered through a gastric probe 25 . The criteria for rats to experience dyslipidemia were if their total cholesterol levels were 107 mg/dl, LDL 82.54 mg/dl, HDL < 41.49 mg/dl, and triglycerides 60 mg/dl 26 .…”

Section: Research Samplementioning

confidence: 99%

Hypolipidemic Effects of Modified Edamame Tempeh Flour on Lipid Profile Levels in Dyslipidemia Rats

Nurkistin

Tamtomo

Wiboworini

2022

AMNT

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Background: Dyslipidemia is a lipid metabolism disorder that causes an increase or decrease in plasma lipid concentrations. Comprehensive management is an attempt to prevent and reduce dyslipidemia, one of which is nutritional therapy. Edamame contains nutrients such as protein, fat, fiber, and isoflavones that have the potential to improve lipid profiles. Edamame tempeh production is one way to improve product quality that is improving nutritional quality, digestibility, and bioavailability. Edamame tempeh modification is conducted by adding yeast Saccharomyces cerevisiae. This yeast plays a role in increasing the isoflavone levels and the product containing β-glucan. Objectives: This research aims to analyze the effects of edamame tempeh flour (ET) and modified edamame tempeh flour (MET) on lipid profile levels in dyslipidemic rats. Methods: This research was a true experimental with a randomized controlled group pretest-posttest design. Thirty-six Sprague Dawley male white rats that met the inclusion criteria were randomized and divided into six treatment groups consisting of negative control, positive control, the dose of ET flour was 2.7 g/200gBW and 5.4 g/200gBW, the dose of MET flour was 2.7 g/200gBW and 5.4 g/200gBW. The intervention was carried out once per day in the morning for 28 days. The parameters observed included total cholesterol, LDL-C, and HDL-C levels measured by the CHOP-PAP method and triglyceride levels using the GPO-PAP method with a spectrophotometer measuring instrument. Examination of lipid profile levels was carried out three times. All statistical tests used a 95% significance level. Results: There was a significant difference in the decrease in total cholesterol, LDL-C, and triglyceride levels as well as an increase in HDL-C levels compared to before the intervention (p<0.05). Conclusions: The administration of ET flour and MET flour could significantly reduce total cholesterol, LDL-C, triglyceride, and increased HDL-C, but the administration of MET flour, especially at a dose of 5.4 g/200gBW, showed a more effective improvement in lipid profile and approached the positive control group compared to ET flour.

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PENGARUH SINBIOTIK KEFIR TEPUNG PISANG BATU (<em>Musa balbisiana</em>) TERHADAP KADAR GLUKOSA DARAH TIKUS SINDROM METABOLIK

Cited by 3 publications

References 0 publications

Potensi Kombinasi Pemberian Ekstrak Rosella dan Pare Menurunkan Kadar Glukosa Darah dan Meningkatkan Kolesterol-HDL pada Tikus Model Sindrom Metabolik

Potensi Kombinasi Pemberian Ekstrak Rosella dan Pare Menurunkan Kadar Glukosa Darah dan Meningkatkan Kolesterol-HDL pada Tikus Model Sindrom Metabolik

Aktivitas Antioksidan Dan Total Flavonoid Es Krim Naga Merah Dan Lidah Buaya Sebagai Nonfarmakoterapi Dmt2

Hypolipidemic Effects of Modified Edamame Tempeh Flour on Lipid Profile Levels in Dyslipidemia Rats

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