This development research was motivated by the fact that the LKPD teaching materials used to support learning activities did not meet 21st century criteria and were not able to hone students' critical thinking skills. LKPD is not yet based on problem solving and utilizes electronic media. This research aims to determine the feasibility, practicality and effectiveness of electronic LKPD on respiratory system material. This research is Research and Development (R&D) research, using Lee & Owens design consisting of analysis, design, development, implementation and evaluation stages. Data collection techniques use questionnaires and tests. Data analysis techniques are quantitative and qualitative. The validation results by material experts and media experts stated that E-LKPD was very valid with validity of 88.33% and 95.58% respectively with the category suitable for use. Based on the teacher assessment results, the category was very good with a percentage of 89.33% in the category very good and feasible in practice. The results of the student response questionnaire showed a percentage of 94.26% in the very good category so that ELKPD is good for use in learning. The effectiveness of E-LKPD after being implemented shows that students' critical thinking abilities have increased with an N-Gain score of 0.56 which is included in the medium category. The conclusion is that E-LKPD based on Problem Based Learning can be used as a learning medium to improve students' critical thinking skills in science learning, especially material on the respiratory system.