Pengembangan Sistem Nanostructured Lipid Carriers (NLC) Meloxicam dengan Lipid Monostearin dan Miglyol 808 Menggunakan Metode Emulsifikasi

Annisa, Rahmi; Hendradi, Esti; Melani, Dewi

doi:10.25026/jtpc.v3i3.102

Cited by 9 publications

(14 citation statements)

References 13 publications

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“…The pH meter electrodes were inserted into 10.00 mL of E. palmifolia SNEEDS, and the number indicated by the pH meter was recorded. Three repeated readings were performed for the sample [16].…”

Section: Formulation Agf Ph 12±05mentioning

confidence: 99%

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Design and optimization of Eleutherine palmifolia extract-loaded SNEDDS using HLB approach

Annisa¹,

Yuwono²,

Hendradi³

2020

JRP

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The novel surfactant system was designed to formulation a self-nanoemulsifying drug delivery system (SNEDDS) based on Hydrophilic Lipophilic Balance (HLB) value. This study aimed to prepare and characterize the Eleutherine palmifolia (E. palmifolia) extract-loaded self-nanoemulsifying drug delivery system (SNEDDS) using a Hydrophilic Lipophilic Balance (HLB) approach. E. palmifolia formulation was prepared using the Miglyol 812 as oil, with two hydrophilic surfactants (tween 20, tween 80) mixed with two lipophilic surfactants (Span 20 and Transcutol). The formulated four binary surfactant combinations with HLB ranging from 11 to 15, and co-surfactant polyethylene glycol [PEG] 400. The characteristics of the optimal formulation showed transmittance value of 97.97 ± 0.17%; emulsification time on artificial intestinal fluid (AIF) media of 52.00 ± 0.03 seconds; artificial gastric fluid (AGF) media of 50.00 ± 0.03 seconds; pH of 8.90 ± 0.06; viscosity of 32.81 ± 0.41 cps; and particle size of 12.08 nm. The selected formulation was a ratio of 2:7:1 composed of Miglyol 812, Tween 80, Transcutol, and PEG 400.

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Section: Formulation Agf Ph 12±05mentioning

confidence: 99%

“…The sample cup was also reassembled on viscometer, turned on, and then left until the reading was stable. Three repeated readings were performed for the sample [16].…”

Section: Viscositymentioning

confidence: 99%

Design and optimization of Eleutherine palmifolia extract-loaded SNEDDS using HLB approach

Annisa¹,

Yuwono²,

Hendradi³

2020

JRP

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“…10 mL of Dayak onion SNEDDS, then electrodes were inserted into SNEDDS Dayak onion, and then the number indicated by the pH meter. 13 Viscosity Viscosity testing was carried out using a cone and plate viscometer (Brookfield, USA). Stationary plates were filled with 0.5 to 20 mL Dayak onion SNEDDS.…”

Section: Transmittance Testmentioning

confidence: 99%

“…Furthermore, the sample cup reassembled on viscometer, and the viscometer is turned on, then left for a while until the reading is stable. 13 Particle Size Analysis This test was analyzed using dynamic light scattering on a particle size analyzer (Nanowave II Microtech, USA). 1 gram of Dayak onion SNEDDS extract was dissolved with 10 mL water (1:10) at 25 o C, then put in a cuvette and measured the particle size distribution in the sample.…”

Section: Transmittance Testmentioning

confidence: 99%

Effect of Vegetable Oil on Self-Nanoemulsifying Drug Delivery System of Dayak Onion [Eleutherine palmifolia (L.) Merr.] Extract using Hydrophilic-lipophilic Balance Approach: Formulation, Characterization

Hendradi¹,

Annisa²,

Yuwono³

2020

ijddt

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Eleutherine palmifolia is a typical plant of Kalimantan that has been empirically used by the Dayak people as a cure for various types of diseases. Self-nanoemulsifying drug delivery system (SNEDDS) is a drug delivery system that can be developed for onion Dayak to improve its absorption profile. Selection of oil phase, surfactant, and cosurfactant have an essential role in SNEDDS of Dayak onion. The aims of this study to determine the effect of the use of vegetable oils on SNEDDS using the HLB approach. Several 40 formulations in each oil phase with HLB ranging between 11 and 15 were screened to acquire stable SNEDDS composition without the presence of phase separation. Formulas optimal obtained F33 (HLB 14) using olive oil at a ratio formula of 1:7:2. F29 (HLB 14), using VCO at a formula ratio of 1:7:2. F14 (HLB 14) uses palm oil at a ratio formula of 2:7:1. The result showed that the optimal formula F33 (olive oil) with 58 nm of the particle size, 84.32 ± 0.00 of the transmittance percentage, 22.00 ± 0,18 of the emulsification time. Formula F29 (VCO) with 19.48 nm of the particle size, 91.78 ± 0.02 of the transmittance percentage, 43.00 ± 0.16 of the emulsification time. Formula F14 (palm oil) with 102 nm of the particle size, 90.93 ± 0.02 of the transmittance percentage, 110 ± 0.34 of the emulsification time. The optimal formula that has good characteristics and stability is the F29 (VCO) formula using tween 20/transcutol as the surfactant, PEG 400, as co-surfactant at a ratio formula of 1:7:2.

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“…Proporsi minyak cair dalam pembentuk struktur lipid pada sistem NLC meningkatkan muatan obat ke dalam sistem, sehingga NLC ini memberikan keuntungan yang menjanjikan dibandingkan dengan SLN. Selain itu, stabilitas dalam bentuk partikel mencegah peristiwa penggabungan partikel dibandingkan dengan sistem pembawa nanoemulsi (Annisa et al, 2016).…”

Section: Pendahuluanunclassified

Pengaruh Panjang Rantai Karbon Lipid Padat terhadap Karakteristik Nanostructured Lipid Carrier Resveratrol

Aisiyah

Harjanti

Nopiyanti

2019

J. Pharm. Sci. Clin. Res.

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Karakteristik kritis nano-structured lipid carrier (NLC) sangat dipengaruhi oleh komponen lipid padat dan lipid cair dalam sistem. Penelitian ini bertujuan untuk mengkaji pengaruh panjang rantai karbon dalam lipid padat terhadap karakteristik NLC. Resveratrol sebagai senyawa antioksidan digunakan sebagai model obat. Sebanyak 3 formula NLC dibuat dengan variasi tipe lemak padat yaitu asam stearat, asam palmitat, dan asam miristat. Lemak padat dengan loading 5%, lemak cair dengan loading 2%, dan Tween 80 dengan loading 4,2% sebagai surfaktan. NLC dibuat dengan metode emulsi diikuti dengan sonikasi untuk memperkecil ukuran partikel. NLC resveratrol dikarakterisasi dengan parameter ukuran partikel, zeta potensial, efisiensi penjerapan, kecepatan pelepasan obat (fluks), dan stabilitas aktivitas antioksidan. Ketiga NLC resveratrol yang diperoleh memiliki karakteristik ukuran partikel 150-280 nm, potensial zeta (-4 mV) – (-15mV), efisiensi penjerapan >80%, nilai fluks 0,02-0,12 mg.cm-2.menit-1, dan penurunan aktivitas antioksidan 5-8% selama penyimpanan 30 hari. Panjang rantai karbon mempengaruhi pembentukan partikel nano dari NLC dengan hubungan parabola dan panjang rantai karbon optimum akan menghasilkan partikel dengan ukuran minimum. Zeta potensial dari ketiga formula menunjukkan perbedaan yang tidak bermakna (p>0,05). Panjang rantai karbon memberikan pengaruh terhadap efisiensi penjerapan secara bermakna (p<0,05). Formula NLC asam palmitat memiliki fluks paling tinggi. Aktivitas antioksidan ketiga formula tidak berbeda bermakna (p>0,05).

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Pengembangan Sistem Nanostructured Lipid Carriers (NLC) Meloxicam dengan Lipid Monostearin dan Miglyol 808 Menggunakan Metode Emulsifikasi

Abstract: The aim this study was to determine the effect of Monostearin and Miglyol 808

Cited by 9 publications

References 13 publications

Design and optimization of Eleutherine palmifolia extract-loaded SNEDDS using HLB approach

Design and optimization of Eleutherine palmifolia extract-loaded SNEDDS using HLB approach

Effect of Vegetable Oil on Self-Nanoemulsifying Drug Delivery System of Dayak Onion [Eleutherine palmifolia (L.) Merr.] Extract using Hydrophilic-lipophilic Balance Approach: Formulation, Characterization

Pengaruh Panjang Rantai Karbon Lipid Padat terhadap Karakteristik Nanostructured Lipid Carrier Resveratrol

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