Penicacids H–J, three new mycophenolic acid derivatives from the marine-derived fungus <i>Rhizopus oryzae</i>

Pilevneli, Amine Dilara; Ebada, Sherif S.; Kaşkatepe, Banu; Konuklugil, Belma

doi:10.1039/d1ra07196c

Cited by 5 publications

(1 citation statement)

References 40 publications

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“…234 Pleosporales strains were the source of phenalenone derivatives 668–670 , 235 and polyketides 671 and 672 . 236 Mycophenolic acid derivatives 673–675 were obtained from Rhizopus oryzae , ( 673 is a known terrestrial metabolite but new MNP and 675 , a known synthetic derivative but new NP 237 ). An untargeted metabolomics approach to a Rhodotorula mucilaginosa extract resulted in the isolation of polyol fatty acid esters 676–679 .…”

Section: Marine Microorganisms and Phytoplanktonmentioning

confidence: 99%

Marine natural products

et al. 2023

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Section: Marine Microorganisms and Phytoplanktonmentioning

confidence: 99%

Marine natural products

et al. 2023

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Antibacterial Activity and AbFtsZ Binding Properties of Fungal Metabolites Isolated from Mexican Mangroves

Carrillo-Jaimes,

Fajardo-Hernández,

Hernández-Sedano

et al. 2024

Rev. Bras. Farmacogn.

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Antimicrobial resistance is emerging as a global health challenge that requires immediate and concerted attention. Accordingly, the WHO has issued alerts urging to continue developing antibiotics with novel mechanisms of action toward clinically important pathogens, including Acinetobacter baumannii. In this context, fungi have played a crucial role in the discovery and development of antibiotics. Therefore, in this work, three fungal strains were prioritized based on their metabolic profiles and antibacterial activity against a pan-resistant isolate of A. baumannii, to identify potential antibiotic molecules. Chemical investigation of the selected fungi (mangrove endophytes) led to the isolation of asperazine (1), aurasperone B (2), aurasperone F (3), TMC-256A1 (4), fonsecin B (5), dianhydroaurasperone C (6), aurasperone A (7), pyrophen (8), and penicillide (9). Moreover, an in vitro assay to detect ligands of the filamentous temperature-sensitive mutant Z enzyme of A. baumannii (AbFtsZ), a GTPase that plays a central role in bacterial division, was developed to correlate the antibacterial properties of the isolated molecules to a mechanism of action. Compounds 1–4 and 9 inhibited the growth of A. baumannii. Interestingly, compounds 2, 3, and 5–9 interacted with AbFtsZ1-412, increasing its GTPase activity. Conversely, compound 4 exhibited an outstanding ability to act as an inhibitor of both the enzymatic activity and the growth of the strain under study. Graphical Abstract

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Novel amides of mycophenolic acid and some heterocyclic derivatives as immunosuppressive agents

Walczak

Iwaszkiewicz-Grześ

Ziomkowska³

et al. 2022

Journal of Enzyme Inhibition and Medicinal Chemistry

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Penicacids H–J, three new mycophenolic acid derivatives from the marine-derived fungus Rhizopus oryzae

Abstract: Penicacids H–J (1–3), three new natural MPA derivatives, were purified from a marine-derived fungus, Rhizopus oryzae, together with two known naphtho-γ-pyrone dimers, asperpyrone A (4) and dianhydroaurasperone C (5).

Cited by 5 publications

References 40 publications

Marine natural products

Marine natural products

Antibacterial Activity and AbFtsZ Binding Properties of Fungal Metabolites Isolated from Mexican Mangroves

Novel amides of mycophenolic acid and some heterocyclic derivatives as immunosuppressive agents

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