Penicillamine as radiation protector against gamma radiation effect on complete blood count parameters of guinea pigs

El-Dessouky, Yasser M. M.; El-Dessouky, Mohamed M; El-Batrawy, Omnya A.

doi:10.4103/azmj.azmj_137_18

Cited by 3 publications

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“…There are concomitant pathomorphological changes, which manifest themselves in the form of cystic cavities, which thin the skin surface and as a result facilitate its trauma, which can provoke secondary infection with secondary flora and the formation of microabscesses (Fig. 1), leading to reduced or partial loss of barrier skin functions in the affected areas (Horalskyi et al, 2005;El-Dessouky et al, 2019). Inflammatory infiltration increases at the 42nd day after infection.…”

Section: Discussionmentioning

confidence: 99%

Dynamics of morphological, immunological and histological changes in microsporіа in guinea pigs

Kisera

Martyniv

Gutyj

2021

Regul. Mech. Biosyst.

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Microsporіа affect different species of animals and humans. The high contagiousness of the pathogen determines the relevance of research into this disease. Microsporum canis is the pathogen that most often causes microsporia. Weakened functions of the immune system and violation of the epithelial barrier of the skin are a favourable factor that causes microspores. The main source of infection is cats, which are involved in the storage and transmission of the pathogen. To clarify the dynamics of morphological, immunological and histological changes in microsporia, blood and skin studies of guinea pigs infected with M. canis were carried out. The animals were divided into two groups of 6 guinea pigs (healthy and sick). Test material (blood and skin) was taken from clinically healthy and sick animals 21 and 42 days after infection. The number of erythrocytes and leukocytes was determined by counting them in the Goryaev chamber, the hemoglobin content – by the method of cyanide hemoglobin. The leukogram was derived based on the counting and differentiation of 200 leukocyte cells in blood smears. Material for histological examination (pieces of skin) was fixed in 10–12% cooled solution of neutral formalin, followed by pouring in paraffin according to the scheme proposed by G. A. Merkulov. The obtained results demonstrated that leukocytosis developed in guinea pigs with microsporia on the 21st and 42nd days; the number of rod-shaped neutrophils increased, that of segmental neutrophils decreased, and that of ESR increased. The immune response to the course of microsporia was manifested in an increase in the percentage of T-lymphocytes, T-suppressors and a decrease in T-helper cells and an increase in T-killers compared with healthy animals. Histological examination showed that on the 21st day after infection, hyphae and spores of the fungus M. canis were localized in the skin. There is swelling of the dermis, stratification of collagen fibers and the accumulation of inflammatory infiltrates around the hair follicles. On the 42nd day, the infiltration spread and dystrophic changes in the skin occurred in the form of desquamation of the epidermis and the formation of acanthosis and hyperkeratosis on the surface of the dermis. The conducted research will allow further assessment of the course of microsporia under the action of various drugs and help establish the most effective method of treatment.

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Section: Discussionmentioning

confidence: 99%

Dynamics of morphological, immunological and histological changes in microsporіа in guinea pigs

Kisera

Martyniv

Gutyj

2021

Regul. Mech. Biosyst.

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Effects of radiation at different dose rates on hematologic parameters in rats

Gul,

Sengul,

Demir

2024

Journal of Radiation Research and Applied Sciences

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Effects of radiotherapy on blood parameters in patients with different types of cancer; single center experience in Iraq

Mahmood,

Talabany,

Khoshnaw

et al. 2024

Iraqi Journal of Hematology

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BACKGROUND: Radiotherapy is important for the treatment of cancer but it is not without side effects on the human body like lethal effects on blood cells. This study aimed to estimate the effect of radiotherapy on blood parameters in cancer patients. PATIENTS AND METHODS: One hundred and two patients from Zhianawa Hospital in Sulaymaniyah Province, Iraq, were included in this study from July 2022 to October 2022. The blood samples were collected for blood analysis and the information of participants was taken through a detailed questionnaire. RESULTS: Out of the 102 patients, 61 (59.8%) females and 41 (40.2%) males, the median age was 50.1 years ± 17.02 years. Forty-nine (48%) of studied patients were in Stage 4 and the most common cancer was breast cancer accounting for 43 (42.2%). We found a statistically significant (P < 0.05) reduction in total white blood cell (WBC) count, red blood cell (RBC) count, hemoglobin, and platelet counts, but regarding neutrophils, the reduction was statistically not significant (P = 0.343). Doses of radiotherapy and more advanced stages of cancer affect the degree of the reduction of blood counts and it can be seen in different ages. The cell drop was significantly lower in younger patients, aged <60 years as related to the curative intent in those age groups. CONCLUSION: The results suggest that radiotherapy has a potential effect on circulating WBCs, RBC counts, and platelets, but not neutrophils and it is related to the stage of cancer and age of the patients.

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Penicillamine as radiation protector against gamma radiation effect on complete blood count parameters of guinea pigs

Cited by 3 publications

References 0 publications

Dynamics of morphological, immunological and histological changes in microsporіа in guinea pigs

Dynamics of morphological, immunological and histological changes in microsporіа in guinea pigs

Effects of radiation at different dose rates on hematologic parameters in rats

Effects of radiotherapy on blood parameters in patients with different types of cancer; single center experience in Iraq

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