Penicillin desensitization: correlation of clinical and immunological events using an in vitro model

Abstract

A patient with actinomycosis was found to have immediate hypersensitivity to penicillin by previously described skin testing methods as well as by a recently described in vitro system utilizing rat peritoneal mast cells. Desensitization to penicillin became imperative, but in using the classical route (the intracutaneous route), systemic anaphylaxis and other comphcations were encountered. Subsequently, successful desensitization was accomplished utilizing the intravenous route. We are able to demonstrate this patient's loss of reactivity to penicillin by the rat mast cell system as well as skin tests and to correlate the immunological state with the clinical course.

Desensitization with Antibiotics

“…Penicillin desensitization was first reported in 1946 [10] and in the ensuing three decades there were a number of additional published case reports [11][12][13][14][15] . Most of these procedures involved parenteral administration of the antibiotic and were associated with significant allergic reactions either during or immediately after the procedure.…”