Penicillin Treatment of Subacute Bacterial Endocarditis

Bacterial Endocarditis

“…Results of treatment of subacute bacterial endocarditis.-The infection is usually controlled in 90-95% of patients if the patient is alive after two weeks' treatment (Friedberg, 1956). The mortality, however, is higher than this figure would suggest, being from 25-45% (Cates and Christie, 1951;Friedberg, 1956;Jones et al, 1947). Morgan and Bland (1959) reported that 21 % of 119 patients died during a ten-year follow-up period.…”

Renal Complications of Bacterial Endocarditis

“…33,37]. Antibiotics have resulted in a decrease in the incidence of focal glomerulonephritis to 18-25% [28,33,34], The lesion is less common in cases of acute bacterial endocarditis, where the reported range is less than 15% [37,41,42], and is rare in cases of right-sided endocardi tis [17,40], Focal glomerular lesions frequently occur along the edges of renal infarcts ( fig. 4), while the major ity of adjacent glomeruli are totally spared [38].…”

“…Azotemia was reported in 20-75% of patients in the preatibiotic period [28][29][30][31], but in only 10-33% of patients in the postantibiotic period [28,32]. Similarly, some 15-25% of deaths in endocarditis were accompanied by uremia before antibiotics [33,34], whereas less than 5% now die with uremia [27,35,36]. These principles were most dramatically illustrated in 1952 by Spain and King [33] who reported a decrease in glomerulonephritis noted at autopsy from 81 to 25% with antibiotic therapy.…”

“…Before the advent of antibi otics, 22-73% of patients with endocarditis developed azotemia [29,31], whereas only 10-33% were reported to be azotemic once effective antibiotics became available [32,34,43,57].…”

Carcinoma of Cardiac Portion of the Stomach

“…The responsible organisms are usually those found in the upper respiratory tract, with Streptococcus viridans predominant Cates and Christie, 1951), and it is generally agreed that the mouth and pharynx constitute the common sites from which the cardiac infection arises, often as a result of local trauma (Jones et al, 1947).…”