Penicillinase-Producing Neisseria gonorrhoeae in Dade County, Florida

Zenilman, JM; Bonner, Mason; Sharp, KL; Ja, Rabb; Er, Alexander

doi:10.1097/00007435-198801000-00011

Cited by 53 publications

(6 citation statements)

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“…There are no reports showing that the ,-lactamase plasmids of H. ducreyi or N. gonorrhoeae confer resistance to antimicrobial agents other than P-lactam antibiotics. It is fascinating, however, to observe an association between the presence of the 5.7-MDa ,3-lactamase plasmid and decreased susceptibility to unrelated antimicrobial agents similar to the correlation between the presence of the 4.4-MDa P-lactamase plasmid and chromosomal antimicrobial resistance observed in N. gonorrhoeae (34). Isolates ofN.…”

Section: Resultsmentioning

confidence: 80%

“…gonorrhoeae that possess the 4.4-MDa P-lactamase plasmid, usually considered to have originated in the Far East, are frequently resistant to tetracycline, erythromycin, and expanded-spectrum cephalosporins and exhibit decreased susceptibility to broad-spectrum cephalosporins such as ceftriaxone. In contrast, penicillin-producing N. gonorrhoeae strains that possess the 3.2-MDa 3-lactamase plasmid, which originated in Africa, are susceptible to these agents (34). The resistances of the gonococcus to non-1-lactam antimicrobial agents are due to chromosomal mutations (9) and are, thus, intrinsic characteristics of gonococcal isolates.…”

Section: Resultsmentioning

confidence: 99%

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Correlation between in vitro antimicrobial susceptibilities and beta-lactamase plasmid contents of isolates of Haemophilus ducreyi from the United States

Motley

Sarafian

Knapp

et al. 1992

Antimicrob Agents Chemother

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We determined the susceptibilities of 94 strains of Haemophilus ducreyi isolated in various municipalities in the United States between 1982 and 1989 to the following antimicrobial agents: amoxicillin-clavulanic acid, ceftriaxone, erythromycin, azithromycin, ciprofloxacin, ofloxacin, trimethoprim, and spectinomycin. Ceftriaxone (MIC, .0.008 ,g/ml), azithromycin (MIC, <0.125 ,Lg/ml), erythromycin (MIC, .0.125 ,ug/ml), ciprofloxacin (MIC, <0.25 ,ug/ml), and ofloxacin (MIC, .0.25 ,ug/ml) were highly active against all isolates. Amoxicillin-clavulanic acid (MICs, 0.25 to 8.0 ,ug/ml), trimethoprim (MICs, 0.06 to 16.0 ,ug/ml), and spectinomycin (MICs, 2.0 to .32.0 jLg/ml) were less active against these isolates. Isolates possessing the 5.7-MDa 1-lactamase plasmid were less susceptible to erythromycin, trimethoprim, and spectinomycin than were isolates possessing the 3.2-MDa I5-lactamase plasmid. The susceptibilities of plasmidless isolates to erythromycin, trimethoprim, and spectinomycin were distributed bimodally; the median MIC for the more susceptible plasmidless isolates corresponded to that for isolates with the 3.2-MDa plasmid, and the median MIC for the less susceptible plasmidless isolates corresponded to that for isolates with the 5.7-MDa plasmid. Thus, plasmid profiles may be valuable markers for geographical variations in antimicrobial susceptibilities of H. ducreyi strains that may indicate the relative efficacy of regimens for the treatment of chancroid. Of the regimens recommended by the U.S. Public Health Service for the treatment of chancroid, our results support the use of erythromycin, ceftriaxone, and ciprofloxacin, and perhaps ofloxacin, but suggest that amoxicillinclavulanic acid and sulfamethoxazole-trimethoprim should be used with caution.

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Section: Resultsmentioning

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Correlation between in vitro antimicrobial susceptibilities and beta-lactamase plasmid contents of isolates of Haemophilus ducreyi from the United States

Motley

Sarafian

Knapp

et al. 1992

Antimicrob Agents Chemother

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“…In a British study, the proportion of serovar IA-1/2 in cervical isolates was four times higher than the proportion in male rectal isolates, whereas the proportion of serovar IB-2 in male rectal isolates was more than three times higher than the proportion in cervical isolates. The (108). The smaller (3.2-MDa) plasmid was associated with a lower penicillin MIC than the larger (4.4-MDa) plasmid.…”

Section: Cephalosporinsmentioning

confidence: 94%

Antimicrobial susceptibility testing of Neisseria gonorrhoeae and implications for epidemiology and therapy

Fekete

1993

Clin Microbiol Rev

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Antimicrobial susceptibility testing (AST) of Neisseria gonorrhoeae has been under development since the early days of antimicrobial agents. However, it is rarely applied to clinical isolates today. The history of the various in vitro tests to determine the susceptibility of N. gonorrhoeae to antibiotics is rich with evidence that these results predict response to therapy for almost all agents tested. Further, AST is a useful and important aspect of strain characterization and disease epidemiology in conjunction with the more specific but laborious techniques of auxotyping, serotyping, and plasmid analysis. Current technology has overcome many of the objections to AST for N. gonorrhoeae with standardization of test media and the development of an accurate disk diffusion AST method that is suited to most clinical laboratories regardless of volume or level of technical expertise. Ironically, the very low level of resistance to the current primary treatment strategy in the United States, ceftriaxone or another potent cephalosporin, makes the use of AST somewhat superfluous.

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“…PPNG strain populations have been analyzed in detail in Miami, Fla., where PPNG infections accounted for approximately 30% of cases of gonorrhea in 1986 (73 (75). On the basis of these observations, we speculate that the PPNG strain population in Miami has undergone temporal changes influenced by the introduction and eradication of different PPNG strains rather than by transfer of the plasmids in the community.…”

Section: Gonococcal Strain Populations In Communitiesmentioning

confidence: 94%