Penicillium chrysogenum endophthalmitis

Abstract

Infections caused by Penicillium chrysogenum are rare. The first case of posttraumatic endophthalmitis caused by this saprophytic fungus is reported. Therapy with amphotericin B and topical natamycin eradicated the organism.

Fungal and Parasitic Infections of the Eye

“…Recent reports include Fusarium moniliforme (257), Exophiala jeanselmei (114), P. boydii (44), A. niger (129), Scytalidium dimidiatum (9), Helminthosporium spp. (65), S. schenckii (292), Penicillium chrysogenum (82), and L. theobromae (29).…”

Treatment of two postoperative endophthalmitis cases due to Aspergillus flavus and Scopulariopsis spp. with local and systemic antifungal therapy

“…Moreover, inability to routinely test the sensitivity of the fungal pathogens under laboratory conditions presents a challenge in deciding on the treatment. Until recently, first choice in medical treatment of fungal endophthalmitis is systemic and intravitreal amphotericin-B [27-31]. However, development of resistance in fungal pathogens and concerns of focal retinal necrosis that might occur even with low doses of amphotericin-B have prompted new therapeutic alternatives to be developed.…”

Combating Fungal Infections

“…Furthermore, patients with AIDS may contact many different fungal infections of the eye and adjacent structures. (Das et al 1994), S. schenckii (Witherspoon et al 1990), Penicillium chrysogenum (Eschete et al 1981), and L. theobromae (Borderie et al 1997). (Table 4.3).…”