Treatment of two postoperative endophthalmitis cases due to Aspergillus flavus and Scopulariopsis spp. with local and systemic antifungal therapy

Aydın, Sayime; Ertuğrul, Mustafa Bülent; Gültekin, Berna; Uyar, Guliz; Kır, Erkin

doi:10.1186/1471-2334-7-87

Cited by 36 publications

(25 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Caspofungin eye drops are effective for treatment of fungal keratitis in rabbits (11, 18) and have good penetration into animal eyes with inflammation or previous corneal abrasion (10, 23). Clinically, caspofungin is administered mostly intravenously (1,4,6,9,19,20) or intravitreally (24) for ocular mycosis. The successful use of topical caspofungin alone (13) or in combination with voriconazole (22) has been reported for two patients.…”

mentioning

confidence: 99%

Penetration of Topically Administered 0.5-Percent Caspofungin Eye Drops into Human Aqueous Humor

Neoh

Leung

Misra

et al. 2011

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Ten participants attending elective anterior segment eye surgery received 0.5% caspofungin eye drops either 1 drop hourly for 4 h or 1 drop an hour before surgery. The eye drops were generally well tolerated. In the absence of inflammation or corneal abrasion, topical caspofungin does not achieve clinically relevant concentrations.Fungal keratitis is a potentially blinding condition, with Candida, Aspergillus, and Fusarium spp. (2, 21) being the common pathogens. Current treatment for fungal keratitis is inadequate (8); thus, alternatives are needed.Caspofungin has activity against a wide range of fungi, with MIC 90 values ranging from 60 to 2,000 ng/ml (15, 23). Caspofungin eye drops are effective for treatment of fungal keratitis in rabbits (11, 18) and have good penetration into animal eyes with inflammation or previous corneal abrasion (10, 23). Clinically, caspofungin is administered mostly intravenously (1,4,6,9,19,20) or intravitreally (24) for ocular mycosis. The successful use of topical caspofungin alone (13) or in combination with voriconazole (22) has been reported for two patients. However, the utility of topical caspofungin in fungal keratitis remains unknown, partly due to limited data on its penetration into human aqueous humor after topical administration. This study aimed to investigate the ocular penetration of 0.5% caspofungin eye drops into human aqueous humor.

show abstract

mentioning

confidence: 99%

Penetration of Topically Administered 0.5-Percent Caspofungin Eye Drops into Human Aqueous Humor

Neoh

Leung

Misra

et al. 2011

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

“…They concluded that due to a lack of clinical correlation with in vitro susceptibility, successful treatment requires surgical debridement [15]. Aydin et al, on the other hand, described 2 patients with postoperative endophthalmitis caused by Scopolariopsis that were successfully treated with local and systemic antifungal therapy [17]. Like most of the patients with sinonasal Scopulariopsis our patient was also treated with both antifungals and wide local excision of the infected tissue with favorite outcome.…”

Section: Discussionmentioning

confidence: 84%

“…Invasive infections with the fungus have been described in immunocompromized patients in multiple organs like heart, brain, lung and cornea [14][15][16][17]. In recent years there has been an increase in the number of publications on the invasive form of the disease with various treatment modalities, none of them proven superior.…”

Section: Discussionmentioning

confidence: 99%

Pediatric invasive sinonasal Scopulariopsis brevicaulis—A case report and literature review

Gluck

Segal

Fruchtman

et al. 2011

International Journal of Pediatric Otorhinolaryngology

View full text Add to dashboard Cite

“…Ayrıca katarakt cerrahisi sonrası A. ustus'un neden olduğu bir fungal endoftalmi olgusu da gözlenmiş-tir (34). Aydın ve arkadaşları (35), A. flavus ve Scopulariopsis spp. 'nin neden olduğu postoperatif iki endoftalmi olgusu bildirmiştir.…”

Section: Endoftalmi Tipleriunclassified

Causative Agents of Endophthalmitis in Turkey: An Overview

Çoban¹,

Erol²,

Çoban³

2015

Klimik Dergisi

View full text Add to dashboard Cite

ÖzetEndoftalmi, humor vitreus ve humor aquosus'un bakteriyel ve fungal infeksiyonlarına verilen addır. Endoftalmi ekzojen ya da endojen yolla mikroorganizmanın bulaşmasıyla oluşur. Ekzojen yolla bulaşmaya travma ve göz cerrahisi neden olurken, endojen yolla bulaşmaya mikroorganizmanın göze kan yoluyla ulaşması neden olur. Steril endoftalmi, operasyonla yerleştirilen kalıcı doğal lens materyali gibi bir nedene ya da toksik bir ajana bağlı olarak gelişir. Çoğu endoftalmi olgusu akuttur ve bu akut olguların tıbbi olarak acilen tedavi edilmesi gerekmektedir. Gecikmiş ya da yetersiz tedavi, geri dönüşü olmayan görme kaybıyla sonuçlanabilir. İnfeksi-yon etkeni tanımlandıktan sonra tedavi protokolünün uygulanması hastaların tedavi başarısını artırmaktadır. Özellikle acil tedavi gerektiren hastalarda olası etkene göre tedavi başlamak önemli bir basamaktır. Medline PubMed, ISI Web, Web of Science, Google Academic ve Türk Medline'da "endoftalmi" ve "Türkiye" anahtar sözcükleri kullanılarak yapılan taramaya göre, Türkiye'den bildirilen ekzojen endoftalmi etkenleri, AbstractEndophthalmitis is described as bacterial and fungal infections of the vitreous and aqueous humor. It is the result of exogenous or endogenous contamination by microorganisms. Exogenous contamination results from ocular surgery and trauma while endogenous contamination results from microorganisms gaining access via bloodstream. Sterile endophthalmitis may result from various causes such as retained native lens material after an operation or toxic agents. Most of endophthalmitis cases are acute and require urgent medical attention. Delayed or inadequate treatment can result in irreversible loss of vision. Application of the proper treatment protocol against defined infectious agent increases success of the treatment. It is important to start the treatment against possible infectious agents particularly in patients requiring urgent attention. According to the research of Medline PubMed, ISI Web, Web of Science, Google Academic and Turkish Medline with key words including "endophthalmitis" and "Turkey", the exogenous endophthalmitis agents reported in There is a wide variety of bacterial agents causing endophthalmitis in Turkey. These bacteria cannot colonize a healthy eye, but they can be transmitted to eye exogenously by operations or trauma. It is important to take maximal sterilization and antisepsis precautions during eye manipulations to prevent from endophthalmitis because microorganisms mentioned above are commonly available in hospital settings. This review evaluated the causative agents of endophthalmitis in Turkey. Klimik Dergisi 2013; 26(2): 44-8.

show abstract

Treatment of two postoperative endophthalmitis cases due to Aspergillus flavus and Scopulariopsis spp. with local and systemic antifungal therapy

Abstract: Background: Endophthalmitis is the inflammatory response to invasion of the eye with bacteria or fungi. The incidence of endophthalmitis after cataract surgery varies between 0.072-0.13 percent. Treatment of endophthalmitis with fungal etiology is difficult.

Cited by 36 publications

References 33 publications

Penetration of Topically Administered 0.5-Percent Caspofungin Eye Drops into Human Aqueous Humor

Penetration of Topically Administered 0.5-Percent Caspofungin Eye Drops into Human Aqueous Humor

Pediatric invasive sinonasal Scopulariopsis brevicaulis—A case report and literature review

Causative Agents of Endophthalmitis in Turkey: An Overview

Contact Info

Product

Resources

About