Penile Angioedema Developing After 3 Years of ACEI Therapy

Miller, Daniel G.; Sweis, Rolla T.; Toerne, Theodore

doi:10.1016/j.jemermed.2011.05.102

Cited by 12 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[64][65][66] The severity of ACEi-A varies; mild ACEi-A is more frequent, but symptoms can recur and potentially worsen overtime. In rare cases, larynx, intestinal and genital angioedema have also been reported.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…In rare cases, larynx, intestinal and genital angioedema have also been reported. [64][65][66] The severity of ACEi-A varies; mild ACEi-A is more frequent, but symptoms can recur and potentially worsen overtime. 67,68 Although rare, serious cases of ACEi-A can require intensive care, including tracheal intubation, and may lead to death.…”

Section: Clinical Featuresmentioning

confidence: 99%

See 1 more Smart Citation

Pharmacogenetics of angiotensin‐converting enzyme inhibitor‐induced angioedema

Liau

Chua

Kennedy

et al. 2019

Clin Experimental Allergy

View full text Add to dashboard Cite

Angioedema is a rare adverse effect of the commonly used angiotensin-converting enzyme inhibitors (ACEi) and is reported to occur with a prevalence of 0.1%-0.7%.Although most ACEi-induced angioedema (ACEi-A) cases are mild, severe cases requiring intensive care and even resulting in death have been reported in the literature. The mechanisms underlying ACEi-A are not yet fully understood, but bradyki-

show abstract

Section: Clinical Featuresmentioning

confidence: 99%

Section: Clinical Featuresmentioning

confidence: 99%

Pharmacogenetics of angiotensin‐converting enzyme inhibitor‐induced angioedema

Liau

Chua

Kennedy

et al. 2019

Clin Experimental Allergy

View full text Add to dashboard Cite

show abstract

“…Symptoms such as a lump in the throat, hoarse voice, and difficulties in swallowing and breathing are signs of impending airway obstruction 13 , 15 . ACE inhibitor–induced angioedema rarely presents with urticaria or swelling outside the head and neck region, although gastrointestinal and genital angioedema have been reported 21 , 36 , 37 . There are no obvious differences in symptoms of angioedema induced by ACE inhibitors and ARBs 26 .…”

Section: Description Of the Phenotypementioning

confidence: 99%

Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System

Wadelius

Marshall

Islander

et al. 2014

Clin Pharmacol Ther

View full text Add to dashboard Cite

Angioedema is a potentially life-threatening adverse reaction to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. To study the genetic etiology of this rare adverse event, international consortia and multicenter recruitment of patients are needed. To reduce patient heterogeneity, we have standardized the phenotype. In brief, it comprises swelling in the head and neck region that first occurs during treatment. It should not coincide with urticaria or have another likely cause such as hereditary angioedema.

show abstract

“… 1 Though ACEI-RA is well-described in the literature and not a rare disorder, angioedema of the penis has only been reported in three previous publications (four total cases overall). 2 – 4 In each case, the symptoms were isolated to the genitalia without additional sites of involvement. Here we present the first known case of a patient with delayed-onset ACEI-RA that was initially isolated to the genitalia with evolvement to the oropharynx, and discuss possible etiologies and treatment options for emergency department (ED) management.…”

Section: Introductionmentioning

confidence: 96%

An Unusual Case of Angiotensin-Converting-Enzyme InhibitorRelated Penile Angioedema with Evolution to the Oropharynx

Wagner¹,

Bench²,

Plantmason³

2015

WestJEM

View full text Add to dashboard Cite

A 52-year-old African American male with a long history of poorly controlled hypertension presented to the emergency department (ED) with two days of genital edema and pain. During ED work-up, the patient developed sudden onset of non-pitting, non-pruritic, and non-urticarial upper lip edema. Review of his antihypertensive medication list revealed that he normally took benazepril, highly suggestive of a diagnosis of angiotensin-converting-enzyme inhibitor-related angioedema (ACEI-RA). We present the first reported case of penile ACEI-RA that progressed to involve the oropharynx. The ED management of the condition and some of the newer treatment options available for ACEI-RA is also briefly discussed.

show abstract

Penile Angioedema Developing After 3 Years of ACEI Therapy

Cited by 12 publications

References 16 publications

Pharmacogenetics of angiotensin‐converting enzyme inhibitor‐induced angioedema

Pharmacogenetics of angiotensin‐converting enzyme inhibitor‐induced angioedema

Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System

An Unusual Case of Angiotensin-Converting-Enzyme InhibitorRelated Penile Angioedema with Evolution to the Oropharynx

Contact Info

Product

Resources

About