Penile primary melanoma: analysis of 6 patients treated at Brazilian national cancer institute in the last eight years

Bechara, Gustavo Ruschi; Schwindt, Aline Barros de Santos; Ornellas, Antônio Augusto; Silva, Diogo Eugenio Abreu da; Lott, Felipe; Campos, Franz

doi:10.1590/s1677-5538.ibju.2013.06.08

Cited by 34 publications

(36 citation statements)

References 27 publications

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“…The recommendations for treatment of the MIS penis, due its rarity, [5,6] are very poor and variable. [1] Eight papers are the only reports of this entity in English and German literature (Table 1). [1,4,5,18–22] In 1976, Paul [18] reported a case of lentigo maligna melanoma on glans penis, that some pathologists considered to be a MIS, a noninvasive skin growth.…”

Section: Discussionmentioning

confidence: 99%

“…[1] Eight papers are the only reports of this entity in English and German literature (Table 1). [1,4,5,18–22] In 1976, Paul [18] reported a case of lentigo maligna melanoma on glans penis, that some pathologists considered to be a MIS, a noninvasive skin growth. [23] MIS of the penis was described for the first time in 1984 by Begun et al [19] in a 31-year-old male.…”

Section: Discussionmentioning

confidence: 99%

“…Primary penile and male urethra melanoma is a rare malignant neoplasm that mostly affects elderly patients, from the sixth and seventh decades of life. [1] In literature, approximately 200 cases were described and they represented less than 1.4% of primary carcinomas of the penis [1,2] and 0.1% to 0.2% of all extraocular melanomas. [3] Most frequently, the lesion is located on the glans (55%), followed by foreskin (28%), penile shaft (9%) and urethral meatus (8%).…”

Section: Introductionmentioning

confidence: 99%

“…[3] Most frequently, the lesion is located on the glans (55%), followed by foreskin (28%), penile shaft (9%) and urethral meatus (8%). [1,4] Melanoma in situ (MIS) of the penis is even more rare. [5,6] There is lack of consensus on the extent of treatment that is indicated.…”

Section: Introductionmentioning

confidence: 99%

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Melanoma in situ of penis

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Melanoma in situ of penis

et al. 2017

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“…Classificada como uma patologia insidiosa que acomete principalmente homens na terceira idade, muito embora possa incidir em indivíduos mais jovens, uma vez que aproximadamente 22% dos casos são registrados em pacientes com idade inferior a 40 anos. No Brasil, esses tumores correspondem a 2% das neoplasias malignas do homem, sendo cinco vezes mais prevalente nas regiões Norte e Nordeste em comparação com as outras regiões (2)(3) .…”

Section: Introductionunclassified

Nursing performance in the care of patients with penile cancer / Atuação do enfermeiro no cuidado ao paciente com câncer de pênis / Actuación del enfermero en el cuidado al paciente con cáncer de pene

et al. 2019

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Objetivo: conhecer a atuação do enfermeiro no cuidado ao paciente com câncer de pênis. Metodologia: estudo descritivo, abordagem qualitativa, realizado com cinco enfermeiras, por meio de entrevista semiestruturada e análise de prontuários, em um hospital de referência para o câncer em Belém do Pará. Utilizou-se o método de análise de conteúdo de Bardin. A pesquisa foi autorizada pelo Comitê de Ética em Pesquisa da Faculdade Metropolitana da Amazônia, com o número de parecer 2.574.409. Resultados: o cuidado de enfermagem se dá de forma sistematizada, respeitando a individualidade, mesmo não existindo um protocolo específico. Da análise de conteúdo surgiram quatro categorias: protocolo existente para o cuidado ao paciente com câncer de pênis, aplicação da Sistematização da Assistência de Enfermagem, identificação dos Diagnósticos de Enfermagem, aplicação das Intervenções de Enfermagem. Conclusão: sugere-se a elaboração e adoção de Procedimentos Operacionais Padrão para ser utilizado juntamente com a Sistematização da Assistência de Enfermagem, pois, não apenas uniformizam as ações dos profissionais, mas também contribuem com assistência de qualidade e a segurança do paciente.Descritores: Neoplasias Penianas. Avaliação em Enfermagem. Enfermagem Oncológica.

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Metformin pretreatment reduces effect to dacarbazine and suppresses melanoma cell resistance

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Marinello

Brito

et al. 2021

Cell Biology International

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Oxidative stress role on metformin process of dacarbazine (DTIC) inducing resistance of B16F10 melanoma murine cells are investigated. To induce resistance to DTIC, murine melanoma cells were exposed to increasing concentrations of dacarabazine (DTIC‐res group). Metformin was administered before and during the induction of resistance to DTIC (MET‐DTIC). The oxidative stress parameters of the DTIC‐res group showed increased levels of malondialdehyde (MDA), thiol, and reduced nuclear p53, 8‐hydroxy‐2ʹ‐deoxyguanosine (8‐OH‐DG), nuclear factor kappa B (NF‐ĸB), and Nrf2. In presence of metformin in the resistant induction process to DTIC, (MET‐DTIC) cells had increased antioxidant thiols, MDA, nuclear p53, 8‐OH‐DG, Nrf2, and reducing NF‐ĸB, weakening the DTIC‐resistant phenotype. The exclusive administration of metformin (MET group) also induced the cellular resistance to DTIC. The MET group presented high levels of total thiols, MDA, and reduced percentage of nuclear p53. It also presented reduced nuclear 8‐OH‐DG, NF‐ĸB, and Nrf2 when compared with the control. Oxidative stress and the studied biomarkers seem to be part of the alterations evidenced in DTIC‐resistant B16F10 cells. In addition, metformin administration is able to play a dual role according to the experimental protocol, preventing or inducing a DTIC‐resistant phenotype. These findings should help future research with the aim of investigating DTIC resistance in melanoma.

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Penile primary melanoma: analysis of 6 patients treated at Brazilian national cancer institute in the last eight years

Cited by 34 publications

References 27 publications

Melanoma in situ of penis

Melanoma in situ of penis

Nursing performance in the care of patients with penile cancer / Atuação do enfermeiro no cuidado ao paciente com câncer de pênis / Actuación del enfermero en el cuidado al paciente con cáncer de pene

Metformin pretreatment reduces effect to dacarbazine and suppresses melanoma cell resistance

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