Introduction: Coronavirus Disease 2019 is an infectious disease caused by the SARS-CoV-2 virus which is transmitted mainly through saliva or secretions from the nose when an infected person coughs or sneezes. One way to prevent the wider spread of the COVID-19 pandemic is by vaccination. Purpose: To determine factors related to community participation in the COVID-19 vaccination program in Batu Merah State, Ambon City in 2021. Methode: This study was an analytical study using primary data with a cross-sectional approach. The sample were residents of Batu Merah State, aged 18 years, totaling 204 people taken using cluster random sampling technique. Results: As many as 59 respondents (28.9%) had received the first dose of vaccination and as many as 42 respondents (20.6%) had received the first and second doses of vaccination. Meanwhile, as many as 103 respondents (50.5%) have not been vaccinated. The role of the environment is mostly found in the supportive category, which is 136 respondents (66.7%), the most motivation is in the medium category, which is 125 respondents (61.3%), the most economic level is in the lower middle category as many as 117 respondents ( 57.4%), the highest confidence was in the medium category, which was 110 respondents (53.9%), and the most convenience was in the fairly easy category, which was 163 respondents (79.9%). Conclusion: There is a relationship between the role of the environment, motivation, economic level, confidence, convenience with community participation in the COVID-19 vaccination program in Batu Merah State, Ambon City in 2021.