Pennes’ 1948 paper revisited

Wissler, Eugene H.

doi:10.1152/jappl.1998.85.1.35

Cited by 353 publications

(207 citation statements)

References 5 publications

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“…To achieve good simulation results, each wavelength should span at least three meshes [22]. The initial sound pressure of all elements was 0 Pa, the initial temperature of the liver and the tumour was set to 37 C, that of the ribs and the fat was set to 32 C, and that of the environment (water) was set to 20 C.…”

Section: Simulation Resultsmentioning

confidence: 99%

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A novel sound-blocking structure based on the muffler principle for rib-sparing transcostal high-intensity focused ultrasound treatment

Chao

Hsu

et al. 2015

International Journal of Hyperthermia

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(2015) A novel sound-blocking structure based on the muffler principle for rib-sparing transcostal high-intensity focused ultrasound treatment, International Journal of Hyperthermia, 31:5, 507-527, DOI: 10.3109/02656736.2015 AbstractThe main challenge in transcostal high-intensity focused ultrasound therapy is minimising heat deposition in the ribs while ensuring that a sufficient dose is delivered to the target region. Current approaches rely on expensive multichannel phased-array systems to turn the individual transducer on and off according to either geometrical arrangements or complicated wave calculations. To protect the ribs from heating, the ultrasound energy must not only not reach the ribs, but must also not accumulate in front of the ribs. The research in this paper proposes a different approach, of attaching a sound-blocking structure in front of the rib cage with similar effects to those of an engine exhaust muffler. The sound-blocking structure is based on the muffler principle to prevent ultrasound energy from reaching the ribs and reduce the amount of energy reflected back to the applicator. Finite element simulations with a 0.5-MHz transducer of the overall sound fields and temperature distribution showed that the ultrasound pressure and energy level would decrease behind the novel sound-blocking structures, thereby resulting in a lower temperature at the ribs than at the tumour. Without the protecting structure, the rib temperature reached 104.19 C whereas with the structure it reached only 37.86 C. An experimental set-up using porcine ribs with a phantom was also developed to validate the concept, which showed that the rib temperature reached 73 C without protection within 1 min of ablation time whereas it reached 36.5 C with the device. The tumour region in the tests reached 51C and 49 C with and without protection, respectively.

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Section: Simulation Resultsmentioning

confidence: 99%

“…The time variation and the temperature distribution of the heating effect are based on the Pennes equation [37]. The Pennes equation (as in Equation 13) takes into account blood perfusion, metabolism, and the heat conduction of the tissue.…”

Section: Bioheat Transfer Theorymentioning

confidence: 99%

A novel sound-blocking structure based on the muffler principle for rib-sparing transcostal high-intensity focused ultrasound treatment

Chao

Hsu

et al. 2015

International Journal of Hyperthermia

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“…The tissue temperature increment results from both power and time. MW heating thermal effects can be roughly described by Pennes' Bioheat equation [31]:…”

Section: Equationsmentioning

confidence: 99%

High Temperature Hyperthermia in Breast Cancer Treatment

Rubio¹,

Salas²

2013

Hyperthermia

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“…An analysis of thermal process and corresponding tissue damage taking into account theses parameters will be very beneficial for thermal destruction of the tumor in medical practices, for example for laser surgery and thermotherapy for treatment planning and optimal control of the treatment outcome, often used in treatment of cancer. The first model, taking account on the blood perfusion, was introduced by Pennes see (Pennes, 1948) (see also (Wissler, 1998) where the paper of Pennes is revisited). The model is based on the classical thermal diffusion system, by incorporating the effects of metabolism and blood perfusion.…”

Section: Problem Definitionmentioning

confidence: 99%

Thermal Therapy: Stabilization and Identification

Belmiloudi¹

2011

Heat Transfer - Mathematical Modelling, Numerical Methods and Information Technology

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44 pages, In "Heat Transfer - Mathematical Modelling, Numerical Methods and Information Technology", A. Belmiloudi (Ed.), InTech (Open Access Publisher), Vienna, 2011 - ISBN 978-953-307-550-1International audienceMotivated by topics and issues critical to human health and safety of treatment, the problem studied in this chapter derives from the modeling and stabilizing control of the transport of thermal energy in biological systems with porous structures. First, the modeling of thermal transport by perfusion within the framework of the theory of porous media is presented and the governing equations are established. The thermal processes within the tissues are predicted by using some generalized uncertain evolutive nonlinear bioheat transfer type models with nonlinear Robin boundary conditions, by taking into account porous structures and directional blood flow. Afterwards the existence, the uniqueness and the regularity of the solution of the state equation are presented as well as stability and maximum principle under extra assumptions. Second, we introduce the initial perturbation problem and give the existence and uniqueness of the perturbation solution and obtain a stability result. Third, the real-time identification and robust stabilization problems are formulated, in different situations, in order to reconstitute simultaneously the blood perfusion rate, the porosity parameter, the heat transfer parameter, the distributed energy source terms and the heat flux due to the evaporation, which affect the effects of thermal physical properties on the transient temperature of biological tissues, and to control and stabilize the desired online temperature and thermal damage provided by MRI measurements. Because, it is now well-known that a controlled and stabilized temperature field does not necessarily imply a controlled and stabilized tissue damage. This work includes results concerning the existence of the optimal solutions, the sensitivity problems, adjoint problems, necessary optimality conditions and optimization problems. Next, we analyse the case when data are measured in only some points in space-time domain, and the case where the body Ω is constituted by different tissue types which occupy finitely many disjointed subdomains. Some numerical strategies, based on adjoint control optimization , in order to perform the robust control, are also discussed. Finally, control and stabilization problems for a coupled thermal, radiation transport and coagulation processes modeling the laser-induced thermotherapy in biological tissues, during cancer treatment, are analyzed

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Pennes’ 1948 paper revisited

Cited by 353 publications

References 5 publications

A novel sound-blocking structure based on the muffler principle for rib-sparing transcostal high-intensity focused ultrasound treatment

A novel sound-blocking structure based on the muffler principle for rib-sparing transcostal high-intensity focused ultrasound treatment

High Temperature Hyperthermia in Breast Cancer Treatment

Thermal Therapy: Stabilization and Identification

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