Pentachlorophenyl esters of N-carbobenzoxy-L-amino acids

Solution‐Phase Peptide Synthesis

“…In order to form the peptide bond from an amino ester under mild conditions, the ester moiety should be activated [234]. Of these, p-nitrophenyl ester 96 [77], 2,4,5-trichlorophenyl ester 97 [236], pentachlorophenyl ester 98 [237], and pentafluorophenyl ester 99 [238] are widely used. It can be considered as a type of mixed anhydride from the carboxylic acid and thiophenol.…”

Carrier design: Synthesis and conformational studies of poly (L-lysine) based branched polypeptides with hydroxyl groups in the side chains

“…The polymerization in our laboratory. Z-Ser-OPcp 23 (Pcp: pentachlorophenyl) was continued for 2 days. The reaction mixture was then and Z-Thr-OPcp 24 were synthesized from Z-Ser-OH 25 and filled in Visking tube (cutoff 8000-12,000) and dialyzed Z-Thr-OH.…”

ChemInform Abstract: TRYPSIN INHIBITORS. I. SYNTHESIS OF PROTECTED PEPTIDES RELATED TO SEQUENCE 1‐10 OF PORCINE PANCREATIC SECRETORY TRYPSIN INHIBITOR II (KAZAL)

“…3) was obtained from thecorrespondingethyl ester (A-11) by treatment with hydrazine hydrate. The tripeptide Nabenzyloxycarbonyl -N"nitroarginylglutamylalanine hydrazide (A-V) was prepared by stepwise elongation starting from alanine tertbutyloxycarbonylhydrazide (73) using successively a-1 -succinimidyl-y-tert-butyl benzyloxycarbonylglutamate (74,75) and pentachlorophenyl NE-benzyloxycarbonyl-Nu-nitroarginine (76) or…”