Pentoxifylline in Strokes: A Clinical Study

Abstract

The results of a comparative clinical study with pentoxifylline -- a new vasoactive compound -- and xanthinol nicotinate in fifty-eight patients suffering from cerebral thrombosis with hemiplegia or monoplegia, are presented. Pentoxifylline appeared to be more effective in reducing motor deficit and was significantly better in improving the patients' intelligence and memory score. Recovery from speech deficit was equally well seen with both drugs.

The Families of Cognition Enhancers

“…Three structurally closely related phosphodiesterase inhibitors seem to have similar properties: Pentoxifylline reverses age-dependent deficits in spatial memory in rats (De Toledo-Morrel/ et al, 1984). A number of clinical data show effectiveness of the compound in cerebral insufficiency or stroke (Hsu et al, 1988;Hartmann, 1985;Janaki, 1980;Harwart, 1979). Some authors describe the psychointelleetual effects of pentoxifylline in these patients (Ghose, 1987;PamettietaI., 1986;PamettietaI., 1985).…”