Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke

Bath, F J; Asplund, Kjell; Bath, Philip M

doi:10.1002/14651858.cd000162

Cited by 18 publications

(21 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…247,439,440 Markedly elevated blood pressure after an acute ischemic event may increase the risk of conversion from an ischemic to a hemorrhagic lesion, with lifethreatening implications. 441 However, inducing hypertension to increase cerebral blood flow has been attractive on the basis of experimental data.…”

Section: Induced Hypertension For the Management Of Acute Ischemicmentioning

confidence: 99%

Guidelines for the Early Management of Adults With Ischemic Stroke

Adams¹,

Zoppo²,

Alberts³

et al. 2007

Circulation

1,063

745

View full text Add to dashboard Cite

Purpose-Our goal is to provide an overview of the current evidence about components of the evaluation and treatment of adults with acute ischemic stroke. The intended audience is physicians and other emergency healthcare providers who treat patients within the first 48 hours after stroke. In addition, information for healthcare policy makers is included. Key Words: AHA Scientific Statements Ⅲ emergency medical services Ⅲ stroke Ⅲ acute cerebral infarction Ⅲ tissue plasminogen activator †Deceased. The American Heart Association makes every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel. Specifically, all members of the writing group are required to complete and submit a Disclosure Questionnaire showing all such relationships that might be perceived as real or potential conflicts of interest. Methods-Members

show abstract

Section: Induced Hypertension For the Management Of Acute Ischemicmentioning

confidence: 99%

Guidelines for the Early Management of Adults With Ischemic Stroke

Adams¹,

Zoppo²,

Alberts³

et al. 2007

Circulation

1,063

745

View full text Add to dashboard Cite

show abstract

“…Similarly, uncontrolled open trials have suggested that PTX may improve stroke outcome in humans (Bath et al, 2000). A recent meta-analysis that included five trials with methylxanthines, administered either intravenously or orally, found insufficient evidence to assess the effectiveness and safety of methylxanthines after acute ischemic stroke (Bath et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…A recent meta-analysis that included five trials with methylxanthines, administered either intravenously or orally, found insufficient evidence to assess the effectiveness and safety of methylxanthines after acute ischemic stroke (Bath et al, 2000). However, a collaborative group is being formed to further assess the effects of methylxanthine derivatives in stroke patients in view of their multiple pharmacological properties as anti-inflammatories, inhibitors of free radical production, neuroprotectors, vasodilators, and antiplatelet agents (Bath et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Pentoxifylline Prevents Spontaneous Brain Ischemia in Stroke-Prone Rats

Banfi¹,

Sironi²,

Simoni³

et al. 2004

J Pharmacol Exp Ther

View full text Add to dashboard Cite

Anti-inflammatory properties of pentoxifylline (PTX) have recently been described. Spontaneously hypertensive strokeprone rats (SHRSP) constitute an animal model that develops an inflammatory condition that precedes the appearance of brain abnormalities. The aim of the present investigation was to assess: 1) the efficacy of PTX treatment in protecting the neural system in SHRSP, and 2) how its anti-inflammatory properties might be involved in this effect. Male SHRSP fed with a permissive diet received no drug or PTX (100 or 200 mg/kg/day). Brain abnormalities detected by magnetic resonance imaging developed spontaneously in control rats after 42 Ϯ 3 days, whereas in rats treated with 100 mg/kg/day PTX, abnormalities developed in only 80% of the animals and only after 70 to 80 days. Treatment with a higher dose of PTX (200 mg/kg/day) completely protected the brain from abnormal development.

show abstract

“…RCTs of vaso-active drugs in acute ischaemic stroke or primary intracerebral haemorrhage will be identified us ing the Cochrane Collaboration Stroke Review Group search strategy [59], Trials will also be identified from computerised searches of MEDLINE, EMBASE, ISI, the Ottawa Stroke Trial Registry [60], reviews of hyperten sion in acute stroke, and existing Cochrane [49,50,[52][53][54][56][57][58] and other systematic reviews [41].…”

Section: Identification O F Trialsmentioning

confidence: 99%

What Is the Correct Management of Blood Pressure in Acute Stroke? The Blood Pressure in Acute Stroke Collaboration

Bath¹,

Bath²

1997

Cerebrovasc Dis

View full text Add to dashboard Cite

Hypertension is associated with a poor outcome in acute stroke. Paradoxically, lowering blood pressure (BP) may also worsen outcome, probably by reducing regional cerebral blood flow and worsening ischaemia. However, no large randomised controlled trials (RCTs) have directly studied the effect of BP reduction or elevation on outcome following stroke. Instead, advice on the management of BP in acute stroke is derived from small trials, case reports and anecdotal experience, and indirectly from RCTs where BP reduction was associated with a poor outcome. A systematic review of existing RCTs in acute stroke where drugs were administered which have the potential for altering BP will answer questions about the relationship between BP changes and outcome. A suitable large RCT of BP lowering or elevation could then be designed based on the findings of the review. Drugs that have been assessed in acute stroke and may lower BP include angiotensin-converting-enzyme inhibitors, beta-blockers, calcium antagonists, magnesium, naftidrofuryl, pentoxifylline, piracetam, prostacyclin and vinpocetine; those that may elevate BP include dobutamine, dopamine and hypervolaemic haemodilution. We have initiated a systematic review, under the auspices of the international Cochrane Collaboration and its Stroke Review Group, which aims to assess the relationship between drug-induced BP changes and outcome. We invite trialists or relevant studies (and systematic reviewers of such drugs) to join this collaborative project by contacting us.

show abstract

Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke

Cited by 18 publications

References 18 publications

Guidelines for the Early Management of Adults With Ischemic Stroke

Guidelines for the Early Management of Adults With Ischemic Stroke

Pentoxifylline Prevents Spontaneous Brain Ischemia in Stroke-Prone Rats

What Is the Correct Management of Blood Pressure in Acute Stroke? The Blood Pressure in Acute Stroke Collaboration

Contact Info

Product

Resources

About