Pentraxin-3: A strong novel biochemical marker for appendicitis in children

Öztan, Mustafa Onur; Gökmen, Ayşegül Aksoy; Özdemir, Tunç; Müderris, Tuba; Kaya, Selçuk; Köylüoğlu, Gökhan

doi:10.1016/j.ajem.2019.01.010

Cited by 17 publications

(31 citation statements)

References 28 publications

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“…[12] The previous studies showed that the sensitivity of WBC in the diagnosis of acute appendicitis ranges between 62% and 97% and the specificity ranges between 53% and 80%. [2,[11][12][13][14] WBC showed an ac- ceptable diagnostic value (AUC=0.778) for acute appendicitis with 83.78% sensitivity and 76% specificity in the present study. Our results also supported the previous meta-analyses suggesting that WBC is more sensitive but less specific than CRP in the early stage of acute appendicitis.…”

Section: Discussionsupporting

confidence: 48%

“…[7] The results from previous studies showed that CRP is not an ideal diagnostic tool for ruling out or determination of acute appendicitis, and has more diagnostic accuracy in detecting complicated appendicitis. [14,[17][18][19] Although the sensitivity of CRP in the diagnosis of acute appendicitis ranged between 35% and 86% and the specificity ranges between 57% and 93% in the literature, [11,12,[19][20][21] a CRP cut-off value of 5.65 produced 72.97% sensitivity, 84% specificity, and an excellent diagnostic value (AUC=0.809) in our study. Our results addressed that CRP is still a helpful inflammatory biomarker in the diagnosis of acute appendicitis in children.…”

Section: Discussionmentioning

confidence: 53%

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Diagnostic value of serum pentraxin 3 level in children with acute appendicitis

Duman

Cesur

Doğuç

et al. 2020

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Appendicitis is one of the most common surgical emergencies. Early diagnosis of appendicitis is important in children because any delay in treatment substantially leads to complicated appendicitis. In this study, we aimed to test the diagnostic value of pentraxin 3 (PTX3) level in children with acute appendicitis and to investigate whether there is a relationship between the progression of the disease and PTX3 level. METHODS: This prospective study included 70 children. They were divided into three groups as follows: group 1 (appendicitis; n=37), group 2 (abdominal pain; n=25), group 3 (control; n=8). Demographic data, medical history, the time from the onset of symptoms to blood sampling, operative and pathological findings of the patients were noted, and white blood cell (WBC), C-reactive protein (CRP) and PTX3 values were measured. RESULTS: The mean WBC, CRP and PTX3 values were found to be significantly increased in the appendicitis group (p<0.001). PTX3 has the highest diagnostic value (AUC=0.828), specificity (88%) and positive predictive value (90%) in the appendicitis group. WBC values did not show a significant correlation with the time periods (p=0.999). The mean CRP level of the appendicitis group in 24-48 hours was found to be higher than in 0-24 hours, but this was marginally significant (p=0.068). On the other hand, PTX3 value was significantly correlated with the time periods (p<0.05). CONCLUSION: This study showed that PTX3 is a valuable inflammatory biomarker in the diagnosis of acute appendicitis and also documented that PTX3 is useful for predicting the progression of the disease.

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Section: Discussionsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 53%

Diagnostic value of serum pentraxin 3 level in children with acute appendicitis

Duman

Cesur

Doğuç

et al. 2020

Ulus Travma Acil Cerrahi Derg

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“…Similar to the previous study, high PTX3 sensitivity and specificity were found when compared to the other biomarkers tested. PTX3 showed superiority and accuracy in the third group [ 14 ]. However, the median PTX3 level reported in this study was 12.60 ng/mL, which is much higher than the median reported by Aygun et al [ 4 ].…”

Section: Reviewmentioning

confidence: 99%

“…However, the previous studies show how PTX3 with the aid of IL-6 might change that in the near future by not only diagnosing acute appendicitis but also predicting the likelihood of perforation in those individuals. One important limitation of the four studies is that they were single-center studies with different approaches [ 4 , 6 , 14 , 15 ]. Also, only two of them assessed the association of IL-6 and PTX3 with appendicitis.…”

Section: Reviewmentioning

confidence: 99%

Pentraxin-3, Interleukin-6, and Acute Appendicitis: Biomarkers That Need Further Exploration

Abouhamda¹

2020

Cureus

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Acute appendicitis is one of the most common abdominal emergencies that present in the hospital. With acute appendicitis, there is always a possibility of complications of perforation and peritonitis. Even though medicine has advanced substantially in different investigational modalities, appendicitis is confirmed clinically with the aid of a clinical approach (i.e., Alvarado Score), laboratory, and investigational modalities. However, biomarkers such as pentraxin-3 and interleukin-6 have been recently researched to assess the possibility of confirming the diagnosis of acute appendicitis in both adults and the pediatric age group. This article breaks down the previous research on pentraxin-3 and interleukin-6 biomarkers in relation to appendicitis and proposes a new hypothetical way of confirming the diagnosis.

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“…This was possibly the case in many previous studies. [8][9][10][11] However, extreme values in a linear scale are an integral feature of a logarithmic/exponential distribution [5][6][7] and should not be missed.…”

mentioning

confidence: 99%