Pentraxin 3: An Immuno-Regulator in the Lungs

Balhara, Jyoti; Koussih, Latifa; Zhang, Jingbo; Gounni, Abdelilah Soussi

doi:10.3389/fimmu.2013.00127

Cited by 35 publications

(45 citation statements)

References 81 publications

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“…23 Pentraxin-3 (Ptx3) secretion is one of the major strategies used by myeloid cells to eliminate fungal infections. 24,25 Ptx3, a soluble secreted pattern recognition receptor, is induced in DCs, macrophages, and neutrophils upon TLR triggering 26,27 and is linked to the phagocytic capacity of cells, 28 as well as to the formation of neutrophil extracellular traps. 29 Ptx3 is able to recognize and bind A. fumigatus conidia, 30 and functional impairment of Ptx3 function is linked with a severe form of IA in patients following bone marrow (BM) 31 and solid organ transplants 32 as a result of lowered phagocytic activity and fungal clearance.…”

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confidence: 99%

Impaired calcineurin signaling in myeloid cells results in downregulation of pentraxin-3 and increased susceptibility to aspergillosis

et al. 2017

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Treatment of post-transplant patients with immunosuppressive drugs targeting the calcineurin-nuclear factor of activated T cells (NFAT) pathway, including cyclosporine A or tacrolimus, is commonly associated with a higher incidence of opportunistic infections, such as Aspergillus fumigatus, which can lead to severe life-threatening conditions. A component of the A. fumigatus cell wall, β-glucan, is recognized by dendritic cells (DCs) via the Dectin-1 receptor, triggering downstream signaling that leads to calcineurin-NFAT binding, NFAT translocation, and transcription of NFAT-regulated genes. Here, we address the question of whether calcineurin signaling in CD11c-expressing cells, such as DCs, has a specific role in the innate control of A. fumigatus. Impairment of calcineurin in CD11c-expressing cells (CD11ccnb1) significantly increased susceptibility to systemic A. fumigatus infection and to intranasal infection in irradiated mice undergoing bone marrow transplant. Global expression profiling of bone marrow-derived DCs identified calcineurin-regulated processes in the immune response to infection, including expression of pentraxin-3, an important antifungal defense protein. These results suggest that calcineurin inhibition directly impairs important immunoprotective functions of myeloid cells, as shown by the higher susceptibility of CD11ccnb mice in models of systemic and invasive pulmonary aspergillosis, including after allogeneic bone marrow transplantation. These findings are relevant to the clinical management of transplant patients with severe Aspergillus infections.

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confidence: 99%

Impaired calcineurin signaling in myeloid cells results in downregulation of pentraxin-3 and increased susceptibility to aspergillosis

et al. 2017

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“…Also, Ptx3, when bound to pathogenic components, activates dendritic cells, which is instrumental in initiating an appropriate T cell response. Another mechanism by which Ptx3 initiates the thread of innate immunity is activating the complement cascade [3,14,15]. Ptx3 is also reported to upregulate tissue factor expression in endothelial cells and play a role in thrombogenesis [16].…”

Section: Discussionmentioning

confidence: 99%

“…Ptx3 has been reported as a biomarker of different immunopathological diseases and its relevance with the resolution of infections and diseases has also been studied. The level of circulating Ptx3 is low in healthy human condition, but increases in inflammatory states starting from very early stages [3]. In recent studies, Ptx3 level changes in lung diseases (chronic obstructive lung disease, acute lung injury, asthma, lung cancer, pulmonary infections) have been reported [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Pentraxin 3: a new biomarker for determining the probability of acute pulmonary embolism

Yolcu¹

2019

Ann Clin Anal Med

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Aim: Pentraxin 3 (Ptx3) is a new biomarker in inflammatory disorders and thromboembolic events. Several studies showed elevated levels of Ptx3 in acute coronary syndrome, infectious diseases, and malignancies. In our study, we aimed to evaluate the relationship between Well's Score and Ptx 3 levels in Pulmonary embolism (PE) patients for determining the probability and severity of the disease. Material and Method: Twenty-two PE patients diagnosed with CT angiography presented to our emergency department and 20 healthy adults as a control group were enrolled in the study. Age, gender, Ptx3, CRP, D-dimer levels and Well's Scores of the patients were noted. After one month, Ptx3, CRP and quantitative D-Dimer levels of the patients were tested again. Results: Mean 1st Ptx3 level of the PE group was higher than the 2nd Ptx3 level and the Ptx3 level of the control group. In the PE group, mean 1st Ptx3 level of the females was 1.87 ± 0.48 and 2.37 ± 0.96 in males and was not significantly different. The 1st Ptx3 levels and the 2nd Ptx3 levels of the PE groups were significantly different (p=0.001). The 1st Ptx3 levels of the PE group and the Ptx3 levels of the control group were significantly different (p=0.001). The 2nd Ptx3 level of the PE group and Ptx3 levels of the control group were significantly different (p=0.001). In the PE group, 1st Ptx3 levels were significantly related with Well's Score of the patients (p=0.001). Discussion: Ptx3 is an important inflammatory marker and secreted from a wide range of cells including adipocytes, cardiomyocytes, brain cell, endothelial cells, and alveolar epithelial cells and may be helpful in determining the probability of PE in suspicious patients in the emergency department.

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“…One such possible marker is pentraxin 3 (PTX3). PTX3 is a soluble pattern recognition receptor,16 recognizing pathogen-associated molecular patterns expressed by microorganisms 17. PTX3 is induced in response to proinflammatory stimuli16 and toll-like receptor (TLR) interactions17 and contributes to innate resistance to pathogens 16.…”

Section: Introductionmentioning

confidence: 99%

“…PTX3 is a soluble pattern recognition receptor,16 recognizing pathogen-associated molecular patterns expressed by microorganisms 17. PTX3 is induced in response to proinflammatory stimuli16 and toll-like receptor (TLR) interactions17 and contributes to innate resistance to pathogens 16. PTX3 levels have been shown to be elevated in a murine bacterial infection model,18 in sepsis,19–21 and in inflammatory rheumatic disease 22.…”

Section: Introductionmentioning

confidence: 99%

Investigating the role of pentraxin 3 as a biomarker for bacterial infection in subjects with COPD

Thulborn¹,

Dilpazir²,

Haldar³

et al. 2017

COPD

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BackgroundPentraxin 3 (PTX3) is an acute phase protein, involved in antibacterial resistance. Recent studies have shown PTX3 levels to be elevated in the presence of a bacterial infection and in a murine sepsis model.ObjectiveWe aim to investigate if sputum PTX3 can be used as a biomarker for bacterial infection in subjects with COPD.Materials and methodsSputum samples from 142 COPD patients (102 men) with a mean (range) age of 69 years (45–85) and mean (SD) post-bronchodilator percentage predicted forced expiratory volume in 1 second (FEV1) of 50% (19) were analyzed for PTX3, using a commercial assay at stable state and during an exacerbation. Association with bacteria, from culture, quantitative real-time polymerase chain reaction (qPCR) and colony-forming units (CFU) was investigated.ResultsThe geometric mean (95% CI) PTX3 level at stable state was 50.5 ng/mL (41.4–61.7). PTX3 levels correlated with absolute neutrophil count in sputum (r=0.37; P<0.01), but not FEV1 or health status. There was a weak correlation between PTX3 and bacterial load (CFU: r=0.29, P<0.01; 16S qPCR: r=0.18, P=0.05). PTX3 was a poor predictor of bacterial colonization (defined as >105 CFU/mL at stable state) with a receiver-operating characteristic (ROC) area under the curve (AUC) of 0.59 and 95% confidence interval (CI) 0.43–0.76 (P=0.21). During an exacerbation, there was a modest increase in PTX3 (fold difference 0.15, 95% of difference 0.02–0.29; P=0.02), and PTX3 fared better at identifying a bacteria-associated exacerbation (ROC AUC 0.65, 95% CI 0.52–0.78, P=0.03).ConclusionPTX3 is associated with bacterial infection in patients with COPD, but its utility as a biomarker for identifying a bacteria-associated exacerbation warrants further studies.

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Pentraxin 3: An Immuno-Regulator in the Lungs

Cited by 35 publications

References 81 publications

Impaired calcineurin signaling in myeloid cells results in downregulation of pentraxin-3 and increased susceptibility to aspergillosis

Impaired calcineurin signaling in myeloid cells results in downregulation of pentraxin-3 and increased susceptibility to aspergillosis

Pentraxin 3: a new biomarker for determining the probability of acute pulmonary embolism

Investigating the role of pentraxin 3 as a biomarker for bacterial infection in subjects with COPD

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